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neurobiotin  (Vector Laboratories)
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Vector Laboratories neurobiotin
Verified tyrosine hydroxylase-positive neurons from MitoPark mice exhibit altered electrophysiological parameters. In a separate experiment, neurons were filled with 0.2% <t>neurobiotin</t> and recorded with an emphasis on obtaining multiple dependent electrophysiological measures from each cell. Cells were later stained (A) for neurobiotin (left) and TH (middle), and cells that definitively co-stained for both markers (right) were analyzed for their electrophysiological parameters. Consistent with previous results, recordings in neurons from MitoPark mice exhibited decrease cell capacitance (B), increased input resistance (C), and decreased Ih (D), spike width (E), and peak current observed in response to iontophoresis of dopamine (F). Two-tailed unpaired t tests. **p < 0.01, ***p < 0.001.
Neurobiotin, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Verified tyrosine hydroxylase-positive neurons from MitoPark mice exhibit altered electrophysiological parameters. In a separate experiment, neurons were filled with 0.2% neurobiotin and recorded with an emphasis on obtaining multiple dependent electrophysiological measures from each cell. Cells were later stained (A) for neurobiotin (left) and TH (middle), and cells that definitively co-stained for both markers (right) were analyzed for their electrophysiological parameters. Consistent with previous results, recordings in neurons from MitoPark mice exhibited decrease cell capacitance (B), increased input resistance (C), and decreased Ih (D), spike width (E), and peak current observed in response to iontophoresis of dopamine (F). Two-tailed unpaired t tests. **p < 0.01, ***p < 0.001.

Journal: The Journal of Neuroscience

Article Title: Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease

doi: 10.1523/JNEUROSCI.1395-15.2016

Figure Lengend Snippet: Verified tyrosine hydroxylase-positive neurons from MitoPark mice exhibit altered electrophysiological parameters. In a separate experiment, neurons were filled with 0.2% neurobiotin and recorded with an emphasis on obtaining multiple dependent electrophysiological measures from each cell. Cells were later stained (A) for neurobiotin (left) and TH (middle), and cells that definitively co-stained for both markers (right) were analyzed for their electrophysiological parameters. Consistent with previous results, recordings in neurons from MitoPark mice exhibited decrease cell capacitance (B), increased input resistance (C), and decreased Ih (D), spike width (E), and peak current observed in response to iontophoresis of dopamine (F). Two-tailed unpaired t tests. **p < 0.01, ***p < 0.001.

Article Snippet: Spontaneous firing was measured with either the loose cell attached method using pipettes of 9–10 MΩ resistance filled with Na HEPES plus 20 m m NaCl (290 mOsm/L, pH 7.40), or with pipettes of 2.5–4 MΩ resistance filled with internal solution containing the following (in m m ): 115 K-methylsulfate, 20 NaCl, 1.5 MgCl 2 , 10 HEPES, 10 BAPTA, 2 ATP, and 0.4 GTP, pH 7.35–7.40, 267–275 mOsm/L, plus 0.2% neurobiotin (Vector Laboratories) immediately before gaining access to the interior compartment of the cell.

Techniques: Staining, Two Tailed Test