solani Search Results


t pedis dsm 18691t  (ATCC)
92
ATCC t pedis dsm 18691t
T Pedis Dsm 18691t, supplied by ATCC, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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atcc collection  (ATCC)
93
ATCC atcc collection
Atcc Collection, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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iz mm  (ATCC)
93
ATCC iz mm
Iz Mm, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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s sanguinis atcc  (ATCC)
90
ATCC s sanguinis atcc
S Sanguinis Atcc, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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solani f sp phaseoli snyder hansen fsph  (ATCC)
90
ATCC solani f sp phaseoli snyder hansen fsph
Solani F Sp Phaseoli Snyder Hansen Fsph, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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vancomycin  (ATCC)
94
ATCC vancomycin
Vancomycin, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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s pneumoniae cdc  (ATCC)
92
ATCC s pneumoniae cdc
In vivo PAE of daptomycin against S. <t>pneumoniae</t> ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.
S Pneumoniae Cdc, supplied by ATCC, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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6396 ery b  (ATCC)
92
ATCC 6396 ery b
Antibacterial activity of A-692345 against clinically resistant S. pneumoniae and S. aureus
6396 Ery B, supplied by ATCC, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pmc15 16 1 8 nd nd 48 5  (ATCC)
90
ATCC pmc15 16 1 8 nd nd 48 5
Antibacterial activity of A-692345 against clinically resistant S. pneumoniae and S. aureus
Pmc15 16 1 8 Nd Nd 48 5, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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accession number  (ATCC)
90
ATCC accession number
Antibacterial activity of A-692345 against clinically resistant S. pneumoniae and S. aureus
Accession Number, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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atcc 76132  (ATCC)
90
ATCC atcc 76132
Antibacterial activity of A-692345 against clinically resistant S. pneumoniae and S. aureus
Atcc 76132, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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s typhi dmst 16122  (ATCC)
91
ATCC s typhi dmst 16122
Antibacterial activity of A-692345 against clinically resistant S. pneumoniae and S. aureus
S Typhi Dmst 16122, supplied by ATCC, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


In vivo PAE of daptomycin against S. pneumoniae ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: In vivo PAE of daptomycin against S. pneumoniae ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques: In Vivo, Concentration Assay

In vivo PAEs of free and total daptomycin concentrations of against S. aureus and S. pneumoniae

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: In vivo PAEs of free and total daptomycin concentrations of against S. aureus and S. pneumoniae

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques: In Vivo

Static doses of daptomycin for different dosing intervals

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: Static doses of daptomycin for different dosing intervals

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

Dose-response curves for daptomycin against various strains of S. pneumoniae.

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: Dose-response curves for daptomycin against various strains of S. pneumoniae.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

MICs, static doses, and magnitudes of 24-h AUC/MIC and peak/MIC ratios required to produce a bacteriostatic effect and killing of 1 and 2 log 10 CFU per thigh over 24 h

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: MICs, static doses, and magnitudes of 24-h AUC/MIC and peak/MIC ratios required to produce a bacteriostatic effect and killing of 1 and 2 log 10 CFU per thigh over 24 h

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

AUC over 24 h for free daptomycin associated with the static dose and doses producing killing of 1 and 2 log10 CFU/thigh for multiple strains of S. pneumoniae and S. aureus.

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: AUC over 24 h for free daptomycin associated with the static dose and doses producing killing of 1 and 2 log10 CFU/thigh for multiple strains of S. pneumoniae and S. aureus.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

Antibacterial activity of A-692345 against clinically resistant S. pneumoniae and S. aureus

Journal:

Article Title: Novel Antibacterial Class

doi: 10.1128/AAC.47.12.3831-3839.2003

Figure Lengend Snippet: Antibacterial activity of A-692345 against clinically resistant S. pneumoniae and S. aureus

Article Snippet: Antibacterial spectrum of NRI compounds table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism Resistance a MIC (μg/ml) A-692345 Levofloxacin S. pneumoniae ATCC 6303 32 0.5 ATCC 49619 PEN 16 1 ATCC 5957 PEN 16 1 ATCC 7257 LVX 4 8 ATCC 6396 ERY b , CLX, TET 16 1 ATCC 5649 PEN, ERY c 8 4 S. aureus ATCC 29213 32 0.25 ATCC 1350 PEN, ERY, CLX 32 0.12 ATCC 7667 PEN, OXA 32 0.25 ATCC 7702 PEN, OXA, CHL, TET, GEN, CIP 32 16 ATCC 2175 PEN, OXA, ERY, CLX, TET, GEN, CHL 32 0.25 ATCC 7681 PEN, OXA, ERY, CLX, CHL, GEN, CIP 32 8 ATCC 3405 PEN, OXA, ERY, CLX, TET, GEN, CIP 32 16 Open in a separate window a Resistance phenotype determined by NCCLS criteria (data not shown).

Techniques: Activity Assay