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Image Search Results
Journal: Biomolecules & Therapeutics
Article Title: Exploring LEPR -Linked Metabolic Diversity through Gut Microbiome-Metabolome Network Analysis in Non-Obese Adults
doi: 10.4062/biomolther.2025.161
Figure Lengend Snippet: Volcano plots of serum metabolites according to LEPR genotype. Significant differences in circulating serum metabolite levels were identified using the Mann-Whitney U test. The x-axis represents the log2 fold change (FC), and the y-axis represents the -log10 p-value. Vertical lines indicate the significance threshold of FC +- 1.2, and the horizontal line indicates a p -value of 0.05. (A) Comparison of serum metabolite profiles between rs1173100 GA and AA genotypes (B) Comparison between rs1173100 GG and AA genotypes (C) Comparison between rs1137101 GA and GG genotypes.
Article Snippet: The rs1173100 and rs1137101 SNPs were genotyped using the TaqMan SNP Genotyping Assay (
Techniques: MANN-WHITNEY, Comparison
Journal: Biomolecules & Therapeutics
Article Title: Exploring LEPR -Linked Metabolic Diversity through Gut Microbiome-Metabolome Network Analysis in Non-Obese Adults
doi: 10.4062/biomolther.2025.161
Figure Lengend Snippet: Schematic summary of LEPR genotype-linked metabolic diversity and microbiome-metabolome interactions. Genetic variations in LEPR (rs1137101, rs1173100) are associated with distinct systemic metabolic profiles, characterized by alterations in dicarboxylic acids (pimelic acid, malonic acid) and 2,4-dihydroxybutyric acid. Network analysis highlights indole-3-acetate and cholesterol as central hubs bridging specific gut microbial taxa (e.g., Firmicutes, Actinobacteria) with host metabolic phenotypes. These interactions may be mediated via the gut-brain-liver axis and serve as ‘sentinel biomarkers’ for sub-clinical metabolic risk, offering a basis for precision nutrition strategies (e.g., tryptophan modulation) in healthy individuals.
Article Snippet: The rs1173100 and rs1137101 SNPs were genotyped using the TaqMan SNP Genotyping Assay (
Techniques:
Journal: Journal of Clinical Medicine
Article Title: Association of IL7 rs16906115 Polymorphism with Immune-Related Adverse Events in Patients with Advanced Lung Cancer Undergoing Immunotherapy
doi: 10.3390/jcm15041486
Figure Lengend Snippet: Kaplan–Meier survival analysis stratified by IL7 rs16906115 status. ( A ) Overall Survival (OS) and ( B ) Progression-Free Survival (PFS) in patients with advanced NSCLC treated with immunotherapy. The analysis compares Risk Allele Carriers (genotypes AG and AA, red line) versus the Protective Group (genotype GG, green line). Carriers of the A allele showed significantly shorter progression-free survival (PFS) ( p = 0.0029) and overall survival ( p = 0.03) than non-carriers.
Article Snippet: IL7 rs16906115 genotyping was performed using the TaqMan SNP Genotyping Assay (Assay ID:
Techniques: