simgcrsim Search Results


simgcrsim  (Mimetas Inc)
86
Mimetas Inc simgcrsim
FIGURE 3 Astrocytes exacerbate acute endothelial cell barrier permeability caused by simulated deep space radiation. (A–D). Vascular endothelial cell structure permeability 1 day after irradiation with 5-ion <t>SimGCRSim</t> (A, C) or 600 MeV/n 56Fe particles (B, D), quantified as area under the curve of relative fluorescence of dye. Dye, TRITC-conjugated 155 kDa dextran (A, B) or FITC-conjugated 40 kDa dextran (C, D). Endo, endothelial cells alone. Endo + astro, endothelial cells and astrocytes. Open bars, chips with endothelial cells only. Shaded bars, chips with endothelial cells and astrocytes. Blue, 0 Gy sham irradiation. Light red, lower dose (0.25 Gy SimGCRSim, 0.3 Gy 600 MeV/n 56Fe). Dark red, higher dose (0.5 Gy SimGCRSim, 0.82 Gy 600 MeV/n 56Fe). N = 8 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, Dunnett’s multiple comparison test, 2-way ANOVA. Non statistically significant changes are not marked.
Simgcrsim, supplied by Mimetas Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/simgcrsim/simgcrsim/pm36275678-123-16-14
Average 86 stars, based on 1 article reviews
simgcrsim - by Bioz Stars, 2026-10
86/100 stars
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simgcrsim  (Brookhaven Instruments)
86
Brookhaven Instruments simgcrsim
FIGURE 3 Astrocytes exacerbate acute endothelial cell barrier permeability caused by simulated deep space radiation. (A–D). Vascular endothelial cell structure permeability 1 day after irradiation with 5-ion <t>SimGCRSim</t> (A, C) or 600 MeV/n 56Fe particles (B, D), quantified as area under the curve of relative fluorescence of dye. Dye, TRITC-conjugated 155 kDa dextran (A, B) or FITC-conjugated 40 kDa dextran (C, D). Endo, endothelial cells alone. Endo + astro, endothelial cells and astrocytes. Open bars, chips with endothelial cells only. Shaded bars, chips with endothelial cells and astrocytes. Blue, 0 Gy sham irradiation. Light red, lower dose (0.25 Gy SimGCRSim, 0.3 Gy 600 MeV/n 56Fe). Dark red, higher dose (0.5 Gy SimGCRSim, 0.82 Gy 600 MeV/n 56Fe). N = 8 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, Dunnett’s multiple comparison test, 2-way ANOVA. Non statistically significant changes are not marked.
Simgcrsim, supplied by Brookhaven Instruments, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/simgcrsim/simgcrsim/10__2139_slash_ssrn__3641936-244-12-5
Average 86 stars, based on 1 article reviews
simgcrsim - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier

Image Search Results


FIGURE 3 Astrocytes exacerbate acute endothelial cell barrier permeability caused by simulated deep space radiation. (A–D). Vascular endothelial cell structure permeability 1 day after irradiation with 5-ion SimGCRSim (A, C) or 600 MeV/n 56Fe particles (B, D), quantified as area under the curve of relative fluorescence of dye. Dye, TRITC-conjugated 155 kDa dextran (A, B) or FITC-conjugated 40 kDa dextran (C, D). Endo, endothelial cells alone. Endo + astro, endothelial cells and astrocytes. Open bars, chips with endothelial cells only. Shaded bars, chips with endothelial cells and astrocytes. Blue, 0 Gy sham irradiation. Light red, lower dose (0.25 Gy SimGCRSim, 0.3 Gy 600 MeV/n 56Fe). Dark red, higher dose (0.5 Gy SimGCRSim, 0.82 Gy 600 MeV/n 56Fe). N = 8 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, Dunnett’s multiple comparison test, 2-way ANOVA. Non statistically significant changes are not marked.

Journal: Frontiers in immunology

Article Title: Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model.

doi: 10.3389/fimmu.2022.864923

Figure Lengend Snippet: FIGURE 3 Astrocytes exacerbate acute endothelial cell barrier permeability caused by simulated deep space radiation. (A–D). Vascular endothelial cell structure permeability 1 day after irradiation with 5-ion SimGCRSim (A, C) or 600 MeV/n 56Fe particles (B, D), quantified as area under the curve of relative fluorescence of dye. Dye, TRITC-conjugated 155 kDa dextran (A, B) or FITC-conjugated 40 kDa dextran (C, D). Endo, endothelial cells alone. Endo + astro, endothelial cells and astrocytes. Open bars, chips with endothelial cells only. Shaded bars, chips with endothelial cells and astrocytes. Blue, 0 Gy sham irradiation. Light red, lower dose (0.25 Gy SimGCRSim, 0.3 Gy 600 MeV/n 56Fe). Dark red, higher dose (0.5 Gy SimGCRSim, 0.82 Gy 600 MeV/n 56Fe). N = 8 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, Dunnett’s multiple comparison test, 2-way ANOVA. Non statistically significant changes are not marked.

Article Snippet: To assess whether simulated deep space radiation has a similar effect, we exposed BBB OrganoPlates to SimGCRSim or 600 MeV/n 56Fe particles and quantified vascular endothelial permeability at 24 hours after irradiation.

Techniques: Permeability, Irradiation, Comparison

FIGURE 6 Simulated space radiation induces oxidative stress that is partially mitigated by astrocytes. (A–D) Quantification of secreted 8-oxo-dG in supernatants of chips seeded with endothelial cells only (open bars) and endothelial cells + astrocytes (shaded bars) 1 day (A, B) and 7 days (C, D) after irradiation with SimGCRSim (A, C) or 600 MeV/n 56Fe (B, D) particles. Blue, 0 Gy sham irradiation. Light red, lower dose (0.3 Gy 600 MeV/n 56Fe, 0.25 Gy SimGCRSim). Dark red, higher dose (0.82 Gy 600 MeV/n 56Fe, 0.5 Gy SimGCRSim). N = 12 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, 2-way ANOVA, Dunnett’s multiple comparison’s test. Non statistically significant changes are not marked.

Journal: Frontiers in immunology

Article Title: Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model.

doi: 10.3389/fimmu.2022.864923

Figure Lengend Snippet: FIGURE 6 Simulated space radiation induces oxidative stress that is partially mitigated by astrocytes. (A–D) Quantification of secreted 8-oxo-dG in supernatants of chips seeded with endothelial cells only (open bars) and endothelial cells + astrocytes (shaded bars) 1 day (A, B) and 7 days (C, D) after irradiation with SimGCRSim (A, C) or 600 MeV/n 56Fe (B, D) particles. Blue, 0 Gy sham irradiation. Light red, lower dose (0.3 Gy 600 MeV/n 56Fe, 0.25 Gy SimGCRSim). Dark red, higher dose (0.82 Gy 600 MeV/n 56Fe, 0.5 Gy SimGCRSim). N = 12 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, 2-way ANOVA, Dunnett’s multiple comparison’s test. Non statistically significant changes are not marked.

Article Snippet: To assess whether simulated deep space radiation has a similar effect, we exposed BBB OrganoPlates to SimGCRSim or 600 MeV/n 56Fe particles and quantified vascular endothelial permeability at 24 hours after irradiation.

Techniques: Irradiation