sigma stat 3.1 Search Results


stat5 inhibitor stat5  (MedChemExpress)
95
MedChemExpress stat5 inhibitor stat5
Figure 6. CSN1S1 reduces the transcription of β-CN gene by modulating signal transducer and activator of transcription 5a (STAT5a). (A) Relative luciferase activity of primary goat mammary epithelial cells (GMEC) transfected with pGL3-Basic or pGL3-Basic-CSN2. (B) GMEC were co-transfected with both pGL3-Basic-CSN2 and pcDNA3.1-STAT5a (or pcDNA3.1-NC, plasmid ratio is 1:1) followed by infection with ad- enovirus with green fluorescent protein (Ad-GFP) or adenovirus Ad-CSN1S1 (multiplicity of infection of 200), respectively. After 48 h treatment, CSN2 promoter activity was measured. (C) GMEC were incubated with dimethyl sulfoxide (DMSO) or <t>STAT5</t> inhibitor <t>(STAT5-IN-1;</t> 200 μM) followed by both pGL3-CSN2 and siCSN1S1–507 [or negative control small interfering RNA (siNC), 100 nM] co-transfection, respectively. After 48 h treatment, CSN2 promoter activity was measured. Values are presented as means ± SEM from 3 individual cultures (n = 3 goats). *P < 0.05 and **P < 0.01 compared with control (pGL3-Basic, Ad-GFP, or siNC).
Stat5 Inhibitor Stat5, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sigma+stat+3%2E1/STAT5-IN-1/pm32828499-60-10-15
Average 95 stars, based on 1 article reviews
stat5 inhibitor stat5 - by Bioz Stars, 2026-09
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casamino acids aventor  (Chem Impex International)
95
Chem Impex International casamino acids aventor
Figure 6. CSN1S1 reduces the transcription of β-CN gene by modulating signal transducer and activator of transcription 5a (STAT5a). (A) Relative luciferase activity of primary goat mammary epithelial cells (GMEC) transfected with pGL3-Basic or pGL3-Basic-CSN2. (B) GMEC were co-transfected with both pGL3-Basic-CSN2 and pcDNA3.1-STAT5a (or pcDNA3.1-NC, plasmid ratio is 1:1) followed by infection with ad- enovirus with green fluorescent protein (Ad-GFP) or adenovirus Ad-CSN1S1 (multiplicity of infection of 200), respectively. After 48 h treatment, CSN2 promoter activity was measured. (C) GMEC were incubated with dimethyl sulfoxide (DMSO) or <t>STAT5</t> inhibitor <t>(STAT5-IN-1;</t> 200 μM) followed by both pGL3-CSN2 and siCSN1S1–507 [or negative control small interfering RNA (siNC), 100 nM] co-transfection, respectively. After 48 h treatment, CSN2 promoter activity was measured. Values are presented as means ± SEM from 3 individual cultures (n = 3 goats). *P < 0.05 and **P < 0.01 compared with control (pGL3-Basic, Ad-GFP, or siNC).
Casamino Acids Aventor, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sigma+stat+3%2E1/Glycerol/pm39978337-277-208-213
Average 95 stars, based on 1 article reviews
casamino acids aventor - by Bioz Stars, 2026-09
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stat5 inhibitor cas 285986-31-4  (Merck KGaA)
90
Merck KGaA stat5 inhibitor cas 285986-31-4
Figure 6. CSN1S1 reduces the transcription of β-CN gene by modulating signal transducer and activator of transcription 5a (STAT5a). (A) Relative luciferase activity of primary goat mammary epithelial cells (GMEC) transfected with pGL3-Basic or pGL3-Basic-CSN2. (B) GMEC were co-transfected with both pGL3-Basic-CSN2 and pcDNA3.1-STAT5a (or pcDNA3.1-NC, plasmid ratio is 1:1) followed by infection with ad- enovirus with green fluorescent protein (Ad-GFP) or adenovirus Ad-CSN1S1 (multiplicity of infection of 200), respectively. After 48 h treatment, CSN2 promoter activity was measured. (C) GMEC were incubated with dimethyl sulfoxide (DMSO) or <t>STAT5</t> inhibitor <t>(STAT5-IN-1;</t> 200 μM) followed by both pGL3-CSN2 and siCSN1S1–507 [or negative control small interfering RNA (siNC), 100 nM] co-transfection, respectively. After 48 h treatment, CSN2 promoter activity was measured. Values are presented as means ± SEM from 3 individual cultures (n = 3 goats). *P < 0.05 and **P < 0.01 compared with control (pGL3-Basic, Ad-GFP, or siNC).
Stat5 Inhibitor Cas 285986 31 4, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sigma+stat+3%2E1/stat5+inhibitor/pmc04473117-132-17-21
Average 90 stars, based on 1 article reviews
stat5 inhibitor cas 285986-31-4 - by Bioz Stars, 2026-09
90/100 stars
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revman analyses  (STATA Corporation)
99
STATA Corporation revman analyses
Figure 6. CSN1S1 reduces the transcription of β-CN gene by modulating signal transducer and activator of transcription 5a (STAT5a). (A) Relative luciferase activity of primary goat mammary epithelial cells (GMEC) transfected with pGL3-Basic or pGL3-Basic-CSN2. (B) GMEC were co-transfected with both pGL3-Basic-CSN2 and pcDNA3.1-STAT5a (or pcDNA3.1-NC, plasmid ratio is 1:1) followed by infection with ad- enovirus with green fluorescent protein (Ad-GFP) or adenovirus Ad-CSN1S1 (multiplicity of infection of 200), respectively. After 48 h treatment, CSN2 promoter activity was measured. (C) GMEC were incubated with dimethyl sulfoxide (DMSO) or <t>STAT5</t> inhibitor <t>(STAT5-IN-1;</t> 200 μM) followed by both pGL3-CSN2 and siCSN1S1–507 [or negative control small interfering RNA (siNC), 100 nM] co-transfection, respectively. After 48 h treatment, CSN2 promoter activity was measured. Values are presented as means ± SEM from 3 individual cultures (n = 3 goats). *P < 0.05 and **P < 0.01 compared with control (pGL3-Basic, Ad-GFP, or siNC).
Revman Analyses, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sigma+stat+3%2E1/STATA+8%2E0/pm19145725-39-50-54
Average 99 stars, based on 1 article reviews
revman analyses - by Bioz Stars, 2026-09
99/100 stars
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prism software  (Softek Solutions Inc)
90
Softek Solutions Inc prism software
Figure 6. CSN1S1 reduces the transcription of β-CN gene by modulating signal transducer and activator of transcription 5a (STAT5a). (A) Relative luciferase activity of primary goat mammary epithelial cells (GMEC) transfected with pGL3-Basic or pGL3-Basic-CSN2. (B) GMEC were co-transfected with both pGL3-Basic-CSN2 and pcDNA3.1-STAT5a (or pcDNA3.1-NC, plasmid ratio is 1:1) followed by infection with ad- enovirus with green fluorescent protein (Ad-GFP) or adenovirus Ad-CSN1S1 (multiplicity of infection of 200), respectively. After 48 h treatment, CSN2 promoter activity was measured. (C) GMEC were incubated with dimethyl sulfoxide (DMSO) or <t>STAT5</t> inhibitor <t>(STAT5-IN-1;</t> 200 μM) followed by both pGL3-CSN2 and siCSN1S1–507 [or negative control small interfering RNA (siNC), 100 nM] co-transfection, respectively. After 48 h treatment, CSN2 promoter activity was measured. Values are presented as means ± SEM from 3 individual cultures (n = 3 goats). *P < 0.05 and **P < 0.01 compared with control (pGL3-Basic, Ad-GFP, or siNC).
Prism Software, supplied by Softek Solutions Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sigma+stat+3%2E1/prism+software/pm25241069-118-11-14
Average 90 stars, based on 1 article reviews
prism software - by Bioz Stars, 2026-09
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Image Search Results


Figure 6. CSN1S1 reduces the transcription of β-CN gene by modulating signal transducer and activator of transcription 5a (STAT5a). (A) Relative luciferase activity of primary goat mammary epithelial cells (GMEC) transfected with pGL3-Basic or pGL3-Basic-CSN2. (B) GMEC were co-transfected with both pGL3-Basic-CSN2 and pcDNA3.1-STAT5a (or pcDNA3.1-NC, plasmid ratio is 1:1) followed by infection with ad- enovirus with green fluorescent protein (Ad-GFP) or adenovirus Ad-CSN1S1 (multiplicity of infection of 200), respectively. After 48 h treatment, CSN2 promoter activity was measured. (C) GMEC were incubated with dimethyl sulfoxide (DMSO) or STAT5 inhibitor (STAT5-IN-1; 200 μM) followed by both pGL3-CSN2 and siCSN1S1–507 [or negative control small interfering RNA (siNC), 100 nM] co-transfection, respectively. After 48 h treatment, CSN2 promoter activity was measured. Values are presented as means ± SEM from 3 individual cultures (n = 3 goats). *P < 0.05 and **P < 0.01 compared with control (pGL3-Basic, Ad-GFP, or siNC).

Journal: Journal of dairy science

Article Title: Negative regulation of α S1 -casein (CSN1S1) improves β-casein content and reduces allergy potential in goat milk.

doi: 10.3168/jds.2020-18595

Figure Lengend Snippet: Figure 6. CSN1S1 reduces the transcription of β-CN gene by modulating signal transducer and activator of transcription 5a (STAT5a). (A) Relative luciferase activity of primary goat mammary epithelial cells (GMEC) transfected with pGL3-Basic or pGL3-Basic-CSN2. (B) GMEC were co-transfected with both pGL3-Basic-CSN2 and pcDNA3.1-STAT5a (or pcDNA3.1-NC, plasmid ratio is 1:1) followed by infection with ad- enovirus with green fluorescent protein (Ad-GFP) or adenovirus Ad-CSN1S1 (multiplicity of infection of 200), respectively. After 48 h treatment, CSN2 promoter activity was measured. (C) GMEC were incubated with dimethyl sulfoxide (DMSO) or STAT5 inhibitor (STAT5-IN-1; 200 μM) followed by both pGL3-CSN2 and siCSN1S1–507 [or negative control small interfering RNA (siNC), 100 nM] co-transfection, respectively. After 48 h treatment, CSN2 promoter activity was measured. Values are presented as means ± SEM from 3 individual cultures (n = 3 goats). *P < 0.05 and **P < 0.01 compared with control (pGL3-Basic, Ad-GFP, or siNC).

Article Snippet: The specific JAK2 inhibitor AG490 (CAS 133550– 30–8, Sigma-Aldrich) and STAT5 inhibitor STAT5-IN-1 (CAS 285986–31–4, MedChemExpress, Monmouth Junction, NJ) were dissolved in dimethyl sulfoxide (DMSO, Sigma-Aldrich) to produce 50 mM stock solutions.

Techniques: Luciferase, Activity Assay, Transfection, Plasmid Preparation, Infection, Incubation, Negative Control, Small Interfering RNA, Cotransfection, Control