sga360 Search Results


sga360  (MedChemExpress)
94
MedChemExpress sga360
SAA1 induced an inflammatory response in intestinal epithelial cells by activating the TLR4/NF-κB signaling pathway and NLRP3 inflammasome. A The effects of different concentrations of LPS on cell proliferation inhibition and IL- 6 concentration were assessed in NCM460 cells after 12 h of exposure. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs 0 μg/ml group. B and C The effect of the SAA1 inhibitor <t>SGA360</t> on IL- 6 and SAA1 protein expression levels was evaluated in an LPS-induced inflammatory cell model using NCM460 cells. The results are presented as mean ± SD. n = 5. * p < 0.05 vs Control group, ** p < 0.01 vs Control group. D siRNA transfection was used to silence cellular SAA1 expression. The results are presented as mean ± SD. n = 5. * p < 0.05 vs si-Control group, ** p < 0.01 vs si-Control group. E Lentiviral transfection was employed to construct h-SAA1 stable cell lines. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs h-Control group. F The effect of SAA1 on IL- 6 mRNA expression and IL- 6 content in LPS-induced NCM460 cells was investigated. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs Control + LPS group. G Western blotting and gray value analysis were utilized to assess the impact of SAA1 on the expression levels of various proteins including TLR4, p-IKKα/β, IKKβ, p-IκBα, IκBα, p-p65, p65, NLRP3, Caspase- 1, ASC and IL- 1β in LPS-induced NCM460 cells. The results are presented as mean ± SD. n = 5. * p < 0.05 vs Control + LPS group, ** p < 0.01 vs Control + LPS group
Sga360, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sga360/SGA360/pmc12722397-24-0-3
Average 94 stars, based on 1 article reviews
sga360 - by Bioz Stars, 2026-09
94/100 stars
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sga360  (MuseChem Chemicals)
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1-allyl-3-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-1 h -indazole (sga360  (INDOFINE Inc)
90
INDOFINE Inc 1-allyl-3-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-1 h -indazole (sga360
SAA1 induced an inflammatory response in intestinal epithelial cells by activating the TLR4/NF-κB signaling pathway and NLRP3 inflammasome. A The effects of different concentrations of LPS on cell proliferation inhibition and IL- 6 concentration were assessed in NCM460 cells after 12 h of exposure. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs 0 μg/ml group. B and C The effect of the SAA1 inhibitor <t>SGA360</t> on IL- 6 and SAA1 protein expression levels was evaluated in an LPS-induced inflammatory cell model using NCM460 cells. The results are presented as mean ± SD. n = 5. * p < 0.05 vs Control group, ** p < 0.01 vs Control group. D siRNA transfection was used to silence cellular SAA1 expression. The results are presented as mean ± SD. n = 5. * p < 0.05 vs si-Control group, ** p < 0.01 vs si-Control group. E Lentiviral transfection was employed to construct h-SAA1 stable cell lines. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs h-Control group. F The effect of SAA1 on IL- 6 mRNA expression and IL- 6 content in LPS-induced NCM460 cells was investigated. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs Control + LPS group. G Western blotting and gray value analysis were utilized to assess the impact of SAA1 on the expression levels of various proteins including TLR4, p-IKKα/β, IKKβ, p-IκBα, IκBα, p-p65, p65, NLRP3, Caspase- 1, ASC and IL- 1β in LPS-induced NCM460 cells. The results are presented as mean ± SD. n = 5. * p < 0.05 vs Control + LPS group, ** p < 0.01 vs Control + LPS group
1 Allyl 3 (3,4 Dimethoxyphenyl) 7 (Trifluoromethyl) 1 H Indazole (Sga360, supplied by INDOFINE Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sga360/1+allyl+3++3+4+dimethoxyphenyl++7++trifluoromethyl++1+h++indazole++sga360/pmc03126639-92-2-22
Average 90 stars, based on 1 article reviews
1-allyl-3-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-1 h -indazole (sga360 - by Bioz Stars, 2026-09
90/100 stars
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sga360-d5  (Santa Cruz Biotechnology)
N/A
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sga360  (Toronto Research Chemicals)
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sga360-d5  (Toronto Research Chemicals)
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sga360  (Aladdin Scientific Corporation)
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SGA360 was developed as a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties.
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sga360  (Selleck Chemicals)
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SGA360 is a selective modulator of aryl hydrocarbon (Ah) receptor that exhibits anti-inflammatory properties.
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sga360  (TargetMol)
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sga360  (Cayman Chemical)
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SGA360
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Image Search Results


SAA1 induced an inflammatory response in intestinal epithelial cells by activating the TLR4/NF-κB signaling pathway and NLRP3 inflammasome. A The effects of different concentrations of LPS on cell proliferation inhibition and IL- 6 concentration were assessed in NCM460 cells after 12 h of exposure. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs 0 μg/ml group. B and C The effect of the SAA1 inhibitor SGA360 on IL- 6 and SAA1 protein expression levels was evaluated in an LPS-induced inflammatory cell model using NCM460 cells. The results are presented as mean ± SD. n = 5. * p < 0.05 vs Control group, ** p < 0.01 vs Control group. D siRNA transfection was used to silence cellular SAA1 expression. The results are presented as mean ± SD. n = 5. * p < 0.05 vs si-Control group, ** p < 0.01 vs si-Control group. E Lentiviral transfection was employed to construct h-SAA1 stable cell lines. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs h-Control group. F The effect of SAA1 on IL- 6 mRNA expression and IL- 6 content in LPS-induced NCM460 cells was investigated. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs Control + LPS group. G Western blotting and gray value analysis were utilized to assess the impact of SAA1 on the expression levels of various proteins including TLR4, p-IKKα/β, IKKβ, p-IκBα, IκBα, p-p65, p65, NLRP3, Caspase- 1, ASC and IL- 1β in LPS-induced NCM460 cells. The results are presented as mean ± SD. n = 5. * p < 0.05 vs Control + LPS group, ** p < 0.01 vs Control + LPS group

Journal: Inflammation

Article Title: SAA1 Promotes Ulcerative Colitis and Activating Colonic TLR4/NF-κB/NLRP3 Signaling Pathway

doi: 10.1007/s10753-025-02299-0

Figure Lengend Snippet: SAA1 induced an inflammatory response in intestinal epithelial cells by activating the TLR4/NF-κB signaling pathway and NLRP3 inflammasome. A The effects of different concentrations of LPS on cell proliferation inhibition and IL- 6 concentration were assessed in NCM460 cells after 12 h of exposure. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs 0 μg/ml group. B and C The effect of the SAA1 inhibitor SGA360 on IL- 6 and SAA1 protein expression levels was evaluated in an LPS-induced inflammatory cell model using NCM460 cells. The results are presented as mean ± SD. n = 5. * p < 0.05 vs Control group, ** p < 0.01 vs Control group. D siRNA transfection was used to silence cellular SAA1 expression. The results are presented as mean ± SD. n = 5. * p < 0.05 vs si-Control group, ** p < 0.01 vs si-Control group. E Lentiviral transfection was employed to construct h-SAA1 stable cell lines. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs h-Control group. F The effect of SAA1 on IL- 6 mRNA expression and IL- 6 content in LPS-induced NCM460 cells was investigated. The results are presented as mean ± SD. n = 5. ** p < 0.01 vs Control + LPS group. G Western blotting and gray value analysis were utilized to assess the impact of SAA1 on the expression levels of various proteins including TLR4, p-IKKα/β, IKKβ, p-IκBα, IκBα, p-p65, p65, NLRP3, Caspase- 1, ASC and IL- 1β in LPS-induced NCM460 cells. The results are presented as mean ± SD. n = 5. * p < 0.05 vs Control + LPS group, ** p < 0.01 vs Control + LPS group

Article Snippet: SGA360 (HY- 122208, MedChemExpress) was dissolved in normal saline with a concentration of 0.1 mg/ml and utilized following preparation, SAA1 protein (Mouse (His); HY-P700309, MedChemExpress) was dissolved in normal saline with a concentration of 2.5 μg/ml and utilized following preparation.

Techniques: Inhibition, Concentration Assay, Expressing, Control, Transfection, Construct, Stable Transfection, Western Blot