Journal: Toxicology Reports

Article Title: Role of garlic extract and silymarin compared to dimercaptosuccinic acid (DMSA) in treatment of lead induced nephropathy in adult male albino rats

doi: 10.1016/j.toxrep.2015.04.004

Figure Lengend Snippet: Statistical comparison between groups I (negative control), II (positive control), III (GS) and IV (DMSA) regarding kidney function tests (BUN, serum creatinine), kidney lead level and renal antioxidant parameters (GPX&MDA) by ANOVA test.

Article Snippet: Twenty-four hours after the end of treatment in each group animals were sacrificed and venous blood samples were obtained from the retro-orbital plexus of anaesthetized animals, the blood was left for spontaneous coagulation and serum was separated for estimation of kidney function tests (blood urea nitrogen (BUN) and serum creatinine) using Biomerieux France kit by enzymatic colorimetic method .

Techniques: Comparison, Negative Control, Positive Control

Journal: Toxicology Reports

Article Title: Role of garlic extract and silymarin compared to dimercaptosuccinic acid (DMSA) in treatment of lead induced nephropathy in adult male albino rats

doi: 10.1016/j.toxrep.2015.04.004

Figure Lengend Snippet: Statistical comparison between group II (positive control), group V (Pb), group VI (Pb–GS) and group VII (Pb–DMSA) regarding kidney function tests (BUN, serum creatinine), kidney lead level and renal antioxidant parameters (GPX&MDA) by ANOVA test.

Article Snippet: Twenty-four hours after the end of treatment in each group animals were sacrificed and venous blood samples were obtained from the retro-orbital plexus of anaesthetized animals, the blood was left for spontaneous coagulation and serum was separated for estimation of kidney function tests (blood urea nitrogen (BUN) and serum creatinine) using Biomerieux France kit by enzymatic colorimetic method .

Techniques: Comparison, Positive Control

Journal: Experimental and Therapeutic Medicine

Article Title: Human adipose-derived mesenchymal stem cells repair cisplatin-induced acute kidney injury through antiapoptotic pathways

doi: 10.3892/etm.2015.2505

Figure Lengend Snippet: Kidney functional recovery and structural repair using human AD-MSCs in animals with acute kidney injury (AKI). (A) Renal function was assessed daily by the levels of BUN, serum Ccr, urinary mALB and β2 mG. Data are presented as mean ± standard error of the mean (SEM). *P<0.01 and **P<0.005, cisplatin + saline group vs. cisplatin + AD-MSCs group. (B) Representative images from H&E and PAS staining of the kidney sections from the healthy control, cisplatin + saline and cisplatin + human AD-MSCs groups (magnification, × 200). (C) Histopathological scoring of cisplatin-induced kidney tubular injury, as indicated with tubular necrosis, cast formation, loss of brush border and intratubular debris. Histopathological scoring was based on the percentage of affected tubules in the kidney sections. Data are presented as the mean ± SEM. **P<0.005, between indicated groups. AD-MSCs, adipose-derived mesenchymal stem cells; BUN, blood urea nitrogen; Ccr, creatinine clearance rate; mALB, microalbumin; β2 mG, microglobulin; U, urinary; H&E, hematoxylin and eosin; PAS, periodic acid-Schiff.

Article Snippet: Rats were housed in metabolism cages (Nanjing Bian Zhen Bio-science Company, Nanjing, China), and the blood serum and urine were collected every 24 h for determination of renal function by biochemistry analysis, which included measurements of the serum blood urea nitrogen (BUN) level (48T/96T; Biofine, Blaine, WA, USA), the creatinine clearance rate (Ccr) (48T/96T; Shanghai Yanjin Bio-science Company, Shanghai, China), urinary microalbumin (mALB) (cat. no. {"type":"entrez-protein","attrs":{"text":"ARB12655","term_id":"1168039453","term_text":"ARB12655"}} ARB12655 ; Beijing Ai Ran Bio-tech Ltd., Beijing, China) and β2 microglobulin (β2 mG) (Shanghai Yuanyan Bio-science Limited Company, Shanghai, China).

Techniques: Functional Assay, Saline, Staining, Control, Derivative Assay

Journal: Heliyon

Article Title: Up-regulation of PKR pathway contributes to L-NAME induced hypertension and renal damage

doi: 10.1016/j.heliyon.2020.e05463

Figure Lengend Snippet: Estimation of Serum creatinine and blood urea nitrogen (BUN): Statistical analysis was carried out by applying one-way ANOVA, Bonferroni test was used for post hoc analysis.

Article Snippet: Commercial kits for assessment of serum creatinine, blood urea nitrogen, (BUN) were purchased from Arkray Health care Pvt.

Techniques: