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Optibrium seesar software
( A ) Design of resveratrol-type derivatives. ( B ) Synthetic route towards RE-1. (I) 1,3-dichloropropane, NaH, THF, 0 °C-rt, 8 h; (II) pterostilbene, NaH, THF, rt, 16 h, 26%. Docking studies of RES ( C ) and RE-1 ( D ) against VEGF protein. VEGF 1–165 (PDB code: 1FLT) domain was selected as a binding site and docking studies were performed using <t>SEESAR</t> <t>software</t> (13.0 version). RES: resveratrol.
Seesar Software, supplied by Optibrium, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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( A ) Design of resveratrol-type derivatives. ( B ) Synthetic route towards RE-1. (I) 1,3-dichloropropane, NaH, THF, 0 °C-rt, 8 h; (II) pterostilbene, NaH, THF, rt, 16 h, 26%. Docking studies of RES ( C ) and RE-1 ( D ) against VEGF protein. VEGF 1–165 (PDB code: 1FLT) domain was selected as a binding site and docking studies were performed using SEESAR software (13.0 version). RES: resveratrol.

Journal: Molecules

Article Title: Design, Synthesis, and Biological Evaluations of a Novel Resveratrol-Type Analogue Against VEGF

doi: 10.3390/molecules30112345

Figure Lengend Snippet: ( A ) Design of resveratrol-type derivatives. ( B ) Synthetic route towards RE-1. (I) 1,3-dichloropropane, NaH, THF, 0 °C-rt, 8 h; (II) pterostilbene, NaH, THF, rt, 16 h, 26%. Docking studies of RES ( C ) and RE-1 ( D ) against VEGF protein. VEGF 1–165 (PDB code: 1FLT) domain was selected as a binding site and docking studies were performed using SEESAR software (13.0 version). RES: resveratrol.

Article Snippet: Prediction of ADMET properties, including TPSA, Log P , intestinal absorption and so on, was conducted under Optibrium mode of SEESAR software (Version 13.0; https://www.biosolveit.de/ , accessed on 11 April 2024). a,b following Lipinski’s Rule of Five.

Techniques: Binding Assay, Software