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Journal: Nature Reviews. Immunology
Article Title: The trinity of COVID-19: immunity, inflammation and intervention
doi: 10.1038/s41577-020-0311-8
Figure Lengend Snippet: ( 1 ) Antibodies against the spike protein (raised through vaccination or by adoptive transfer) could block severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from interacting with the angiotensin-converting enzyme 2 (ACE2) receptor on host cells. ( 2 ) Protease inhibitors against the serine protease TMPRSS2 can prevent spike protein cleavage, which is necessary for viral fusion into the host cell. Blocking either ACE2 interaction or viral fusion could prevent the virus from infecting the host cell. ( 3 ) Virus-specific memory CD8 + T cells from a previous vaccination or infection can differentiate into effector cells during rechallenge. When they identify infected cells presenting virus-specific epitopes, they degranulate and kill infected cells before they can produce mature virions. ( 4 ) In a novel treatment method that targets the cytokine storm symptoms, the blood of patients with coronavirus disease 2019 (COVID-19) can be passed through customized columns that are specially designed to trap pro-inflammatory cytokines, before the purified blood is passed back into patients.
Article Snippet: NCT04280705 , USA , Title:
Techniques: Adoptive Transfer Assay, Blocking Assay, Infection, Purification
Journal: Nature Reviews. Immunology
Article Title: The trinity of COVID-19: immunity, inflammation and intervention
doi: 10.1038/s41577-020-0311-8
Figure Lengend Snippet: Summary of approved interventional clinical trials for COVID-19 as of March 2020
Article Snippet: NCT04280705 , USA , Title:
Techniques: Infection, Recombinant, Blocking Assay, Derivative Assay, Western Blot, Injection