sch442416 Search Results


sch 442416 2 2 furanyl  (Tocris)
94
Tocris sch 442416 2 2 furanyl
Sch 442416 2 2 Furanyl, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hy 103169  (MedChemExpress)
92
MedChemExpress hy 103169
Hy 103169, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a2ar antagonist sch442416  (Tocris)
93
Tocris a2ar antagonist sch442416
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
A2ar Antagonist Sch442416, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a 2a receptor-specific radiotracer [ 11 c]sch442416  (Vernalis Inc)
90
Vernalis Inc a 2a receptor-specific radiotracer [ 11 c]sch442416
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
A 2a Receptor Specific Radiotracer [ 11 C]Sch442416, supplied by Vernalis Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sch442416  (Axon Medchem LLC)
90
Axon Medchem LLC sch442416
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
Sch442416, supplied by Axon Medchem LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sch442416 - by Bioz Stars, 2026-03
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sch-442416  (Molecular Dynamics Inc)
90
Molecular Dynamics Inc sch-442416
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
Sch 442416, supplied by Molecular Dynamics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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a sch 442416 derivative labeled with a red emitting htrf fluorescent probe  (Cisbio Bioassays)
90
Cisbio Bioassays a sch 442416 derivative labeled with a red emitting htrf fluorescent probe
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
A Sch 442416 Derivative Labeled With A Red Emitting Htrf Fluorescent Probe, supplied by Cisbio Bioassays, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
a sch 442416 derivative labeled with a red emitting htrf fluorescent probe - by Bioz Stars, 2026-03
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11c]sch442416  (Neuropharm Ltd)
90
Neuropharm Ltd 11c]sch442416
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
11c]Sch442416, supplied by Neuropharm Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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11c]sch442416 - by Bioz Stars, 2026-03
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compound sch-442416 (8)  (AstraZeneca ltd)
90
AstraZeneca ltd compound sch-442416 (8)
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
Compound Sch 442416 (8), supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/compound sch-442416 (8)/product/AstraZeneca ltd
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compound sch-442416 (8) - by Bioz Stars, 2026-03
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11c]sch442416 labelling  (Schering-Plough corporation)
90
Schering-Plough corporation 11c]sch442416 labelling
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
11c]Sch442416 Labelling, supplied by Schering-Plough corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sch-442416  (Cayman Chemical)
90
Cayman Chemical sch-442416
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
Sch 442416, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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radiotracer [ 11c]sch442416  (HAMMERSMITH IMANET LIMITED)
90
HAMMERSMITH IMANET LIMITED radiotracer [ 11c]sch442416
( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the <t>A2AR</t> agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .
Radiotracer [ 11c]Sch442416, supplied by HAMMERSMITH IMANET LIMITED, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the A2AR agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .

Journal: JCI Insight

Article Title: IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression

doi: 10.1172/jci.insight.157509

Figure Lengend Snippet: ( A and B ) T cells were stimulated in the absence or presence of the STAT6 inhibitor AS1517499 (100 nM for A ) or 20 ng/mL IL-4 for B. Cells were resuspended in medium supplemented with ATP at 20 μM on day 4 and eATP concentrations were determined after 30 minutes and 1 hour. Results are shown as a percent decline from original concentration. ( C ) Purified T cells were activated for 4 days in the absence or presence of AS1517499, then restimulated with newly added Dynabeads for 6 hours before cells were collected for intracellular cytokine staining and flow cytometry analysis. ( D – F ) Day 4-activated T cells were restimulated with newly added Dynabeads plus/minus adenosine (500 μM for D ), or the A2AR agonist CGS21680 (100 nM for E), or the P2RX antagonist oATP (100 μM for F) for 6 hours and then stained for intracellular cytokines. ( G ) Purified T cells were treated with STAT6 inhibitor AS1517499, A2AR antagonist SCH58621, or both during T cell activation by Dynabeads. On day 4, cells were restimulated by PMA/IONO for 4 hours before being collected for intracellular cytokine staining. Results are pooled from 3 experiments. Data in C are shown as mean ± SEM and compared by paired 2-tailed Student’s t test in A – G .

Article Snippet: Cells were activated for 4 days by anti-CD3/CD28 Dynabeads (Thermo Fisher Scientific, catalog 11132D; bead to cell ratio 1:2) in the presence or absence of cytokines or chemical compounds, including STAT6 inhibitor AS1517499 (100 nM; Axon Medchem, catalog Axon 1992), IL-4 (20 ng/mL; Peprotech, catalog 200-04), and A2AR antagonist SCH442416 (10 μM; TOCRIS, catalog 2463).

Techniques: Concentration Assay, Purification, Staining, Flow Cytometry, Activation Assay