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Image Search Results
Journal: Cancers
Article Title: Propranolol Promotes Glucose Dependence and Synergizes with Dichloroacetate for Anti-Cancer Activity in HNSCC
doi: 10.3390/cancers10120476
Figure Lengend Snippet: The combination of propranolol and DCA synergizes for robust anti-cancer activity in head and neck squamous cell carcinoma (HNSCC), but has little effect on primary tonsil epithelial cells. Cell counting ( A , C , E , G , I ) and trypan blue exclusion results ( B , D , F , H , K ) of mEERL ( A,B ), MLM3 ( C,D ), SCC1 (E,F), and SCC47 ( G,H ) treated with propranolol (40 µM) and/or DCA (10 mM) for 48–72 h. SCC1 and SCC47 are human papillomavirus (HPV)(−) and HPV(+) HNSCC cell lines, respectively. Comparison of Pro + DCA effects in primary human tonsil epithelial cells (1° HTE) versus HNSCC cell lines is shown in ( I ) and ( J ). Values reflects % live cell number or % viability relative to control. Each data point represents mean +/− SEM of n = 3–4 independent biological replicates; p -values reflect t -test results (* p ≤ 0.05, ** p ≤ 0.006, *** p ≤ 0.0001 vs. control for a given cell line; # p ≤ 0.05 vs. propranolol only; † p ≤ 0.05 vs. DCA only; ns = not significant).
Article Snippet:
Techniques: Activity Assay, Cell Counting, Comparison, Control