sb431542 Search Results


130-105-336  (miltenyi biotec)
95
miltenyi biotec 130-105-336
130 105 336, supplied by miltenyi biotec, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/pmc12702056-17-0-3?v=miltenyi+biotec
Average 95 stars, based on 1 article reviews
130-105-336 - by Bioz Stars, 2026-08
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sb431542  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology sb431542
Sb431542, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/pmc08560781-209-22-25?v=Santa+Cruz+Biotechnology
Average 93 stars, based on 1 article reviews
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sb431542  (Tocris)
97
Tocris sb431542
Figure 4. IL12p40 (interleukin 12 p40) deficiency increases Tgfβ2 (transforming growth factor β) dependent Mmp (matrix metalloproteinase) activity. A, mRNA expression of IL12p40, Mmp2, Mmp9, Tgfβ1, and Tgfβ2 in wild-type (WT) bone marrow–derived macrophage (BMDMs) transfected with IL12p40-specific siRNA or negative control siRNA as measured by quantitative real-time polymerase chain reaction. B, mRNA expression of Mmps and Timps in IL12p40−/− BMDMs treated with Tgfβ receptor kinase inhibitor <t>(SB431542)</t> or human recombinant TGFβ2. Representative immunohistochemistry images of MMP2 (C–F) and MMP9 (G–J) in abdominal aorta of experimental mice. Quantification of MMP2 (K) and MMP9 (L) immunostaining in the adventitial region of abdominal aorta from experimental mice. M and N, Representative gelatin zymography for pro-MMP2 (matrix metalloproteinase 2), active MMP2 and pro-MMP9 in aortic rings (M, top), supernatants from aortic rings (M, bottom), and supernatants from BMDMs of indicated groups (N). Scale bar=50 µm. *P<0.05, **P<0.01, ***P<0.001, ns denotes nonsignificant in paired 2-tailed Student t test (A and B) or in Tukey multiple comparisons test (K–L). Ang II indicates angiotensin II.
Sb431542, supplied by Tocris, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/10__1161_slash_atvbaha__118__311969-104-8-15?v=Tocris
Average 97 stars, based on 1 article reviews
sb431542 - by Bioz Stars, 2026-08
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growth factor b  (Selleck Chemicals)
96
Selleck Chemicals growth factor b
Figure 4. IL12p40 (interleukin 12 p40) deficiency increases Tgfβ2 (transforming growth factor β) dependent Mmp (matrix metalloproteinase) activity. A, mRNA expression of IL12p40, Mmp2, Mmp9, Tgfβ1, and Tgfβ2 in wild-type (WT) bone marrow–derived macrophage (BMDMs) transfected with IL12p40-specific siRNA or negative control siRNA as measured by quantitative real-time polymerase chain reaction. B, mRNA expression of Mmps and Timps in IL12p40−/− BMDMs treated with Tgfβ receptor kinase inhibitor <t>(SB431542)</t> or human recombinant TGFβ2. Representative immunohistochemistry images of MMP2 (C–F) and MMP9 (G–J) in abdominal aorta of experimental mice. Quantification of MMP2 (K) and MMP9 (L) immunostaining in the adventitial region of abdominal aorta from experimental mice. M and N, Representative gelatin zymography for pro-MMP2 (matrix metalloproteinase 2), active MMP2 and pro-MMP9 in aortic rings (M, top), supernatants from aortic rings (M, bottom), and supernatants from BMDMs of indicated groups (N). Scale bar=50 µm. *P<0.05, **P<0.01, ***P<0.001, ns denotes nonsignificant in paired 2-tailed Student t test (A and B) or in Tukey multiple comparisons test (K–L). Ang II indicates angiotensin II.
Growth Factor B, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/pmc10462830__mmc2-206-19-24?v=Selleck+Chemicals
Average 96 stars, based on 1 article reviews
growth factor b - by Bioz Stars, 2026-08
96/100 stars
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sb 431542  (Tocris)
96
Tocris sb 431542
Figure 4. IL12p40 (interleukin 12 p40) deficiency increases Tgfβ2 (transforming growth factor β) dependent Mmp (matrix metalloproteinase) activity. A, mRNA expression of IL12p40, Mmp2, Mmp9, Tgfβ1, and Tgfβ2 in wild-type (WT) bone marrow–derived macrophage (BMDMs) transfected with IL12p40-specific siRNA or negative control siRNA as measured by quantitative real-time polymerase chain reaction. B, mRNA expression of Mmps and Timps in IL12p40−/− BMDMs treated with Tgfβ receptor kinase inhibitor <t>(SB431542)</t> or human recombinant TGFβ2. Representative immunohistochemistry images of MMP2 (C–F) and MMP9 (G–J) in abdominal aorta of experimental mice. Quantification of MMP2 (K) and MMP9 (L) immunostaining in the adventitial region of abdominal aorta from experimental mice. M and N, Representative gelatin zymography for pro-MMP2 (matrix metalloproteinase 2), active MMP2 and pro-MMP9 in aortic rings (M, top), supernatants from aortic rings (M, bottom), and supernatants from BMDMs of indicated groups (N). Scale bar=50 µm. *P<0.05, **P<0.01, ***P<0.001, ns denotes nonsignificant in paired 2-tailed Student t test (A and B) or in Tukey multiple comparisons test (K–L). Ang II indicates angiotensin II.
Sb 431542, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/bio_rxiv__64898__2026__01__30__702717-319-47-48?v=Tocris
Average 96 stars, based on 1 article reviews
sb 431542 - by Bioz Stars, 2026-08
96/100 stars
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sb431542  (Biogems International)
95
Biogems International sb431542
Figure 4. IL12p40 (interleukin 12 p40) deficiency increases Tgfβ2 (transforming growth factor β) dependent Mmp (matrix metalloproteinase) activity. A, mRNA expression of IL12p40, Mmp2, Mmp9, Tgfβ1, and Tgfβ2 in wild-type (WT) bone marrow–derived macrophage (BMDMs) transfected with IL12p40-specific siRNA or negative control siRNA as measured by quantitative real-time polymerase chain reaction. B, mRNA expression of Mmps and Timps in IL12p40−/− BMDMs treated with Tgfβ receptor kinase inhibitor <t>(SB431542)</t> or human recombinant TGFβ2. Representative immunohistochemistry images of MMP2 (C–F) and MMP9 (G–J) in abdominal aorta of experimental mice. Quantification of MMP2 (K) and MMP9 (L) immunostaining in the adventitial region of abdominal aorta from experimental mice. M and N, Representative gelatin zymography for pro-MMP2 (matrix metalloproteinase 2), active MMP2 and pro-MMP9 in aortic rings (M, top), supernatants from aortic rings (M, bottom), and supernatants from BMDMs of indicated groups (N). Scale bar=50 µm. *P<0.05, **P<0.01, ***P<0.001, ns denotes nonsignificant in paired 2-tailed Student t test (A and B) or in Tukey multiple comparisons test (K–L). Ang II indicates angiotensin II.
Sb431542, supplied by Biogems International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/pmc12862199-69-30-31?v=Biogems+International
Average 95 stars, based on 1 article reviews
sb431542 - by Bioz Stars, 2026-08
95/100 stars
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sb431542  (Miltenyi Biotec)
95
Miltenyi Biotec sb431542
Figure 4. IL12p40 (interleukin 12 p40) deficiency increases Tgfβ2 (transforming growth factor β) dependent Mmp (matrix metalloproteinase) activity. A, mRNA expression of IL12p40, Mmp2, Mmp9, Tgfβ1, and Tgfβ2 in wild-type (WT) bone marrow–derived macrophage (BMDMs) transfected with IL12p40-specific siRNA or negative control siRNA as measured by quantitative real-time polymerase chain reaction. B, mRNA expression of Mmps and Timps in IL12p40−/− BMDMs treated with Tgfβ receptor kinase inhibitor <t>(SB431542)</t> or human recombinant TGFβ2. Representative immunohistochemistry images of MMP2 (C–F) and MMP9 (G–J) in abdominal aorta of experimental mice. Quantification of MMP2 (K) and MMP9 (L) immunostaining in the adventitial region of abdominal aorta from experimental mice. M and N, Representative gelatin zymography for pro-MMP2 (matrix metalloproteinase 2), active MMP2 and pro-MMP9 in aortic rings (M, top), supernatants from aortic rings (M, bottom), and supernatants from BMDMs of indicated groups (N). Scale bar=50 µm. *P<0.05, **P<0.01, ***P<0.001, ns denotes nonsignificant in paired 2-tailed Student t test (A and B) or in Tukey multiple comparisons test (K–L). Ang II indicates angiotensin II.
Sb431542, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/bio_rxiv__64898__2025__12__23__696164-129-25-28?v=Miltenyi+Biotec
Average 95 stars, based on 1 article reviews
sb431542 - by Bioz Stars, 2026-08
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sb431542  (LKT Laboratories)
90
LKT Laboratories sb431542
Figure 4. IL12p40 (interleukin 12 p40) deficiency increases Tgfβ2 (transforming growth factor β) dependent Mmp (matrix metalloproteinase) activity. A, mRNA expression of IL12p40, Mmp2, Mmp9, Tgfβ1, and Tgfβ2 in wild-type (WT) bone marrow–derived macrophage (BMDMs) transfected with IL12p40-specific siRNA or negative control siRNA as measured by quantitative real-time polymerase chain reaction. B, mRNA expression of Mmps and Timps in IL12p40−/− BMDMs treated with Tgfβ receptor kinase inhibitor <t>(SB431542)</t> or human recombinant TGFβ2. Representative immunohistochemistry images of MMP2 (C–F) and MMP9 (G–J) in abdominal aorta of experimental mice. Quantification of MMP2 (K) and MMP9 (L) immunostaining in the adventitial region of abdominal aorta from experimental mice. M and N, Representative gelatin zymography for pro-MMP2 (matrix metalloproteinase 2), active MMP2 and pro-MMP9 in aortic rings (M, top), supernatants from aortic rings (M, bottom), and supernatants from BMDMs of indicated groups (N). Scale bar=50 µm. *P<0.05, **P<0.01, ***P<0.001, ns denotes nonsignificant in paired 2-tailed Student t test (A and B) or in Tukey multiple comparisons test (K–L). Ang II indicates angiotensin II.
Sb431542, supplied by LKT Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/bio_rxiv__2019__12__16__877498-226-41-68?v=LKT+Laboratories
Average 90 stars, based on 1 article reviews
sb431542 - by Bioz Stars, 2026-08
90/100 stars
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sb431542  (BOC Sciences)
90
BOC Sciences sb431542
RT-qPCR analysis of nupr1b mRNA levels in 4 dpci fbln2 +/+ (n = 4) and fbln2 PL-/- (n = 5) ventricles treated with <t>SB431542</t> and DMSO from one day before cryoinjury to 4 dpci (pools of 2 ventricles per sample). Statistical test: one-way ANOVA followed by Tukey’s post-hoc test. Error bars represent mean ± SD and bars represent median values.
Sb431542, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/pmc12995719-329-12-13?v=BOC+Sciences
Average 90 stars, based on 1 article reviews
sb431542 - by Bioz Stars, 2026-08
90/100 stars
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sb431542  (ReproCELL)
96
ReproCELL sb431542
RT-qPCR analysis of nupr1b mRNA levels in 4 dpci fbln2 +/+ (n = 4) and fbln2 PL-/- (n = 5) ventricles treated with <t>SB431542</t> and DMSO from one day before cryoinjury to 4 dpci (pools of 2 ventricles per sample). Statistical test: one-way ANOVA followed by Tukey’s post-hoc test. Error bars represent mean ± SD and bars represent median values.
Sb431542, supplied by ReproCELL, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/pmc11299523-175-83-87?v=ReproCELL
Average 96 stars, based on 1 article reviews
sb431542 - by Bioz Stars, 2026-08
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sb431542  (CELLAGEN TECHNOLOGY LLC)
90
CELLAGEN TECHNOLOGY LLC sb431542
RT-qPCR analysis of nupr1b mRNA levels in 4 dpci fbln2 +/+ (n = 4) and fbln2 PL-/- (n = 5) ventricles treated with <t>SB431542</t> and DMSO from one day before cryoinjury to 4 dpci (pools of 2 ventricles per sample). Statistical test: one-way ANOVA followed by Tukey’s post-hoc test. Error bars represent mean ± SD and bars represent median values.
Sb431542, supplied by CELLAGEN TECHNOLOGY LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sb431542/pm32386572-577-83-84?v=CELLAGEN+TECHNOLOGY+LLC
Average 90 stars, based on 1 article reviews
sb431542 - by Bioz Stars, 2026-08
90/100 stars
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Image Search Results


Figure 4. IL12p40 (interleukin 12 p40) deficiency increases Tgfβ2 (transforming growth factor β) dependent Mmp (matrix metalloproteinase) activity. A, mRNA expression of IL12p40, Mmp2, Mmp9, Tgfβ1, and Tgfβ2 in wild-type (WT) bone marrow–derived macrophage (BMDMs) transfected with IL12p40-specific siRNA or negative control siRNA as measured by quantitative real-time polymerase chain reaction. B, mRNA expression of Mmps and Timps in IL12p40−/− BMDMs treated with Tgfβ receptor kinase inhibitor (SB431542) or human recombinant TGFβ2. Representative immunohistochemistry images of MMP2 (C–F) and MMP9 (G–J) in abdominal aorta of experimental mice. Quantification of MMP2 (K) and MMP9 (L) immunostaining in the adventitial region of abdominal aorta from experimental mice. M and N, Representative gelatin zymography for pro-MMP2 (matrix metalloproteinase 2), active MMP2 and pro-MMP9 in aortic rings (M, top), supernatants from aortic rings (M, bottom), and supernatants from BMDMs of indicated groups (N). Scale bar=50 µm. *P<0.05, **P<0.01, ***P<0.001, ns denotes nonsignificant in paired 2-tailed Student t test (A and B) or in Tukey multiple comparisons test (K–L). Ang II indicates angiotensin II.

Journal: Arteriosclerosis, Thrombosis, and Vascular Biology

Article Title: Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)–Induced Abdominal Aortic Aneurysm

doi: 10.1161/atvbaha.118.311969

Figure Lengend Snippet: Figure 4. IL12p40 (interleukin 12 p40) deficiency increases Tgfβ2 (transforming growth factor β) dependent Mmp (matrix metalloproteinase) activity. A, mRNA expression of IL12p40, Mmp2, Mmp9, Tgfβ1, and Tgfβ2 in wild-type (WT) bone marrow–derived macrophage (BMDMs) transfected with IL12p40-specific siRNA or negative control siRNA as measured by quantitative real-time polymerase chain reaction. B, mRNA expression of Mmps and Timps in IL12p40−/− BMDMs treated with Tgfβ receptor kinase inhibitor (SB431542) or human recombinant TGFβ2. Representative immunohistochemistry images of MMP2 (C–F) and MMP9 (G–J) in abdominal aorta of experimental mice. Quantification of MMP2 (K) and MMP9 (L) immunostaining in the adventitial region of abdominal aorta from experimental mice. M and N, Representative gelatin zymography for pro-MMP2 (matrix metalloproteinase 2), active MMP2 and pro-MMP9 in aortic rings (M, top), supernatants from aortic rings (M, bottom), and supernatants from BMDMs of indicated groups (N). Scale bar=50 µm. *P<0.05, **P<0.01, ***P<0.001, ns denotes nonsignificant in paired 2-tailed Student t test (A and B) or in Tukey multiple comparisons test (K–L). Ang II indicates angiotensin II.

Article Snippet: In some wells, IL12p40−/− BMDMs were treated with SB431542, Tgfβ receptor kinase inhibitor (15 nmol/L, Tocris Biosciences), or human recombinant Tgfβ2 protein (10 ng/mL, Fisher) for 48 hours.

Techniques: Activity Assay, Expressing, Derivative Assay, Transfection, Negative Control, Real-time Polymerase Chain Reaction, Recombinant, Immunohistochemistry, Immunostaining, Zymography

RT-qPCR analysis of nupr1b mRNA levels in 4 dpci fbln2 +/+ (n = 4) and fbln2 PL-/- (n = 5) ventricles treated with SB431542 and DMSO from one day before cryoinjury to 4 dpci (pools of 2 ventricles per sample). Statistical test: one-way ANOVA followed by Tukey’s post-hoc test. Error bars represent mean ± SD and bars represent median values.

Journal: Nature Cardiovascular Research

Article Title: Attenuation of epicardial activation and myofibroblast abundance via the Fbln2–Nupr1b axis stimulates cardiac regeneration in zebrafish

doi: 10.1038/s44161-026-00785-8

Figure Lengend Snippet: RT-qPCR analysis of nupr1b mRNA levels in 4 dpci fbln2 +/+ (n = 4) and fbln2 PL-/- (n = 5) ventricles treated with SB431542 and DMSO from one day before cryoinjury to 4 dpci (pools of 2 ventricles per sample). Statistical test: one-way ANOVA followed by Tukey’s post-hoc test. Error bars represent mean ± SD and bars represent median values.

Article Snippet: For TGFβ inhibitor treatment, adult fish were treated with 10 μM of SB431542 (BOC Sciences, catalog number B0084-211014) or DMSO, starting from 1 day before cryoinjury until 4 dpci with the solution refreshed every 2 days.

Techniques: Quantitative RT-PCR