Journal: Behavioral Sciences

Article Title: Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

doi: 10.3390/bs12060195

Figure Lengend Snippet: Summary of studies using rTMS for the treatment of TRD.

Article Snippet: Carpenter et al. (2017) [ ] , USA , Randomized double-blind sham-controlled trial , 18–70 years , 92 , L-DLPFC & dorso-medial PFC , Safety and efficacy of an investigational 2-coil rTMS device on depression symptoms , HAM-D 24 C-SSRS ATRQ , 4–6 weeks , 2 Magstim Rapid2 stimulators. single Magstim 70 mm figure eight coil 10 Hz 120 MT in trains of 4 s 26 s rest. 20 daily rTMS. A total 3000 pulses per session , n = 75 showed significantly greater improvement (mean HAMD-24 change) over time for the active (n = 38) versus sham (n = 37) group after 20 sessions (F = 7.174; p = 0.008) & also at the one-month follow-up (F = 6.748; p = 0.010) Effect size (Cohen’s d) for 4-week efficacy of rTMS with the two-coil device (ITT d = 0.58; PP = 0.52) , Baseline, Four weeks , Significant antidepressant effects after only 4-weeks of treatment and was well tolerated. , Headache Muscle twitch/spasms.

Techniques: Derivative Assay, Functional Assay