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Image Search Results
Journal: Nature genetics
Article Title: Increased Enhancer—Promoter Interactions during Developmental Enhancer Activation in Mammals
doi: 10.1038/s41588-024-01681-2
Figure Lengend Snippet: Knock-out analysis of hs654 and hs267/hs266/hs853 enhancers. a,b, Predicted chromatin interactions (black arches) between enhancers (green boxes) and target genes (black boxes) are shown. Gene and enhancer models are not drawn to scale. c,d, Transcriptome-wide mRNA expression changes in E11.5 whole midbrain (MB) of hs654 knock-out mice (c) and in E11.5 forebrain (FB) of hs267/hs266/hs853 knockout mice (d) relative to wildtype mice (WT). Points indicate individual genes, with blue indicating statistically significant differences after adjustment for multiple comparisons (Padj < 0.05). N. S., not significant. P values were calculated using DESeq2.
Article Snippet: RNA isolation, preparation of RNA library and
Techniques: Knock-Out, Expressing