rhigf1 Search Results


rhigf1  (Pacific Pharma Group LLC)
90
Pacific Pharma Group LLC rhigf1
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Rhigf1, supplied by Pacific Pharma Group LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/rhigf1/pmc07579230-66-37-39
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rhigf1 - by Bioz Stars, 2026-09
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200 ng/ml rhigf-1  (FUJIFILM)
90
FUJIFILM 200 ng/ml rhigf-1
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
200 Ng/Ml Rhigf 1, supplied by FUJIFILM, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/200+ng+ml+rhigf+1/pmc04254279-60-40-41
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200 ng/ml rhigf-1 - by Bioz Stars, 2026-09
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rhigf-1  (Biomol GmbH)
90
Biomol GmbH rhigf-1
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Rhigf 1, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/rhigf+1/pmc04752797-292-8-9
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recombinant human igf1 rhigf1  (Biozol Diagnostica Vertrieb GmbH)
90
Biozol Diagnostica Vertrieb GmbH recombinant human igf1 rhigf1
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Recombinant Human Igf1 Rhigf1, supplied by Biozol Diagnostica Vertrieb GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/recombinant+human+igf1+rhigf1/10__1530_slash_eje___12___0701-47-22-25
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recombinant human igf1 rhigf1 - by Bioz Stars, 2026-09
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rhigf-1/bp3  (Shire Plc)
90
Shire Plc rhigf-1/bp3
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Rhigf 1/Bp3, supplied by Shire Plc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/rhigf+1+bp3/pmc08987083-300-20-5
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rhigf-1/bp3 - by Bioz Stars, 2026-09
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total rna from lung tissues exposed to rhigf-1/bp3  (ELK Biotechnology)
90
ELK Biotechnology total rna from lung tissues exposed to rhigf-1/bp3
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Total Rna From Lung Tissues Exposed To Rhigf 1/Bp3, supplied by ELK Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/total+rna+from+lung+tissues+exposed+to+rhigf+1+bp3/pm37322452-65-23-27
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total rna from lung tissues exposed to rhigf-1/bp3 - by Bioz Stars, 2026-09
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rhigf-1  (Neuren Inc)
90
Neuren Inc rhigf-1
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Rhigf 1, supplied by Neuren Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/rhigf+1/pmc05043261-6-6-51
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rhigf-1 infusion at 800 μg/kg/day divided evenly over 24 h  (Animas Corp)
90
Animas Corp rhigf-1 infusion at 800 μg/kg/day divided evenly over 24 h
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Rhigf 1 Infusion At 800 μg/Kg/Day Divided Evenly Over 24 H, supplied by Animas Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/rhigf+1+infusion+at+800+%CE%BCg+kg+day+divided+evenly+over+24+h/pmc04535795-51-0-20
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plasmids for recombinant human insulin-like growth factor-1 (rhigf-1)-spc  (GenScript corporation)
90
GenScript corporation plasmids for recombinant human insulin-like growth factor-1 (rhigf-1)-spc
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Plasmids For Recombinant Human Insulin Like Growth Factor 1 (Rhigf 1) Spc, supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/plasmids+for+recombinant+human+insulin+like+growth+factor+1++rhigf+1++spc/pm40609033-34-0-18
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mecasermin rhigf-1  (Fujisawa Pharmaceutical Co Ltd)
90
Fujisawa Pharmaceutical Co Ltd mecasermin rhigf-1
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Mecasermin Rhigf 1, supplied by Fujisawa Pharmaceutical Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/mecasermin+rhigf+1/pm10623490-117-0-10
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human recombinant igf-1 rhigf-1  (Sinobio Chemistry Co Ltd)
90
Sinobio Chemistry Co Ltd human recombinant igf-1 rhigf-1
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Human Recombinant Igf 1 Rhigf 1, supplied by Sinobio Chemistry Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhigf1/human+recombinant+igf+1+rhigf+1/pm26286172-64-0-4
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rhigf1  (Promega)
90
Promega rhigf1
Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with <t>rhIGF1</t> at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.
Rhigf1, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with rhIGF1 at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.

Journal: Frontiers in Cellular Neuroscience

Article Title: Insulin-Like Growth Factor 1 on the Maintenance of Ribbon Synapses in Mouse Cochlear Explant Cultures

doi: 10.3389/fncel.2020.571155

Figure Lengend Snippet: Effect of exogenous IGF1 on the recovery of ribbon synapses. Cochlear explants from P4 mice were exposed to 50 μg/ml JB1 for 24 h, after which they were incubated with culture media supplemented with rhIGF1 at a concentration of 0.1, 0.15, 0.2, 0.5, or 1, 5 μg/ml for 24 h (A) . (B–D) Maximal-intensity projection images with z -stack of the immunostaining images of specimens cultured without rhIGF1. Panels (E–J) are maximal-intensity projection images of the recovery of ribbon synapses in specimens cultured with 50 μg/ml JB1 for 24 h, followed by rhIGF1 treatment for 24 h at concentrations of 0.2 and 5 μg/ml, respectively. Arrows show the postsynaptic receptor patches and dotted lines indicate the location of an IHC. Exogenous rhIGF1 showed significant effects on the number of both presynaptic ribbons ( K ; p < 0.001 by one-way ANOVA) and postsynaptic receptor patches ( L ; p < 0.001 by one-way ANOVA). Tukey’s post hoc test revealed significant difference at concentrations of 0.2 ( p = 0.034), 1 ( p = 0.017), and 5 μg/ml ( p = 0.010) in the number of presynaptic ribbons, and at concentrations of 0.2 ( p = 0.020) and 5 μg/ml ( p = 0.012) in the number of postsynaptic receptor patches, in comparison with controls which were cultured in 0 μg/ml rhIGF1. Scale bars: 10 μm. Data are expressed as mean (digits at the top of each bar) ± SD. The digits at the bottom of each bar represent the sample number. * p < 0.05 by one-way ANOVA, followed by Tukey’s post hoc test. P4, postnatal day 4; IHC, inner hair cell; SD, standard deviation; rhIGF1, recombinant human insulin-like growth factor-1; ANOVA, analysis of variance.

Article Snippet: To determine the effect of exogenous IGF1 on the recovery of presynaptic ribbons and postsynaptic receptor patches, cochlear explants that had been exposed to 50 μg/ml JB1 for 24 h were incubated with culture media supplemented with rhIGF1 (Orphan Pacific Pharma, Tokyo, Japan) at a concentration of 0, 0.1, 0.15, 0.2, 0.5, 1.0, or 5.0 μg/ml ( n = 5–10) for 24 h. The specimens were then histologically examined.

Techniques: Incubation, Concentration Assay, Immunostaining, Cell Culture, Comparison, Standard Deviation, Recombinant