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Image Search Results
Journal: Oncology Reports
Article Title: Connective tissue growth factor produced by cancer-associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma
doi: 10.3892/or.2020.7669
Figure Lengend Snippet: CTGF expression in CAFs correlates with mesothelioma patient prognosis. (A and B) Analysis of immunohistochemical staining of CTGF. The H-score of CTGF (CTGF score) for all cases is plotted as a histogram. (C) CTGF expression in mesothelioma cells and the Ki-67 index, indicating no significant differences. (D) CTGF expression in CAFs and the Ki-67 index, indicating a positive correlation (r=0.533, P=0.0107; Spearman's correlation test). (E) CTGF expression in mesothelioma cells and the αSMA area index, indicating no significant differences. (F) CTGF expression in CAFs and the αSMA area index, indicating a positive correlation (r=0.502, P=0.0172; Spearman's correlation test). (G) CTGF expression in mesothelioma cells and patient prognosis based on Kaplan-Meier survival curves. CTGF scores were modified by the AE1/AE3 area index values. There were no significant differences in prognosis based on modified CTGF scores (low, <10; high, ≥10). (H) CTGF expression in CAFs and patient prognosis based on Kaplan-Meier survival curves. CTGF scores were modified by the αSMA area index values. There was a significant difference (P=0.0186) in prognosis based on modified CTGF score (low, <30; high, ≥30). αSMA, α-smooth muscle actin; CAFs, cancer-associated fibroblasts; CTGF, connective tissue growth factor.
Article Snippet: The following antibodies were used for IHC: Anti-CTGF (goat polyclonal, dilution 1:50; Santa Cruz Biotechnology, Inc.; cat. no. 14939), anti-AE1/AE3 (mouse monoclonal, dilution 1:100; Biocare Medical; cat. no. ACR011A, B, C),
Techniques: Expressing, Immunohistochemical staining, Staining, Modification