r Search Results


loperamide hydrochloride  (MedChemExpress)
93
MedChemExpress loperamide hydrochloride
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
Loperamide Hydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gccuguccgucuuugucaatt r  (Obio Technology Corp Ltd)
86
Obio Technology Corp Ltd gccuguccgucuuugucaatt r
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
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stn r m  (Boston Scientific Corporation)
86
Boston Scientific Corporation stn r m
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
Stn R M, supplied by Boston Scientific Corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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2 3 bis t butylmethylphosphino quinoxaline strem  (Strem Chemicals)
86
Strem Chemicals 2 3 bis t butylmethylphosphino quinoxaline strem
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
2 3 Bis T Butylmethylphosphino Quinoxaline Strem, supplied by Strem Chemicals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gcaacuucucaggagagaatt r  (Obio Technology Corp Ltd)
86
Obio Technology Corp Ltd gcaacuucucaggagagaatt r
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
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chip pcr  (Azenta)
86
Azenta chip pcr
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
Chip Pcr, supplied by Azenta, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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genewiz n a sox4 pcr f  (Azenta)
86
Azenta genewiz n a sox4 pcr f
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
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l p r p ro f dawley rat p2y6 sprague dawley rat sni m 78 p2y12 sprague dawley rat pst m 77 pannexin 1 sprague dawley rat  (Dawley Inc)
86
Dawley Inc l p r p ro f dawley rat p2y6 sprague dawley rat sni m 78 p2y12 sprague dawley rat pst m 77 pannexin 1 sprague dawley rat
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
L P R P Ro F Dawley Rat P2y6 Sprague Dawley Rat Sni M 78 P2y12 Sprague Dawley Rat Pst M 77 Pannexin 1 Sprague Dawley Rat, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ab 2108811  (NeuroMab)
93
NeuroMab ab 2108811
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
Ab 2108811, supplied by NeuroMab, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse anti β3 subunit  (NeuroMab)
94
NeuroMab mouse anti β3 subunit
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
Mouse Anti β3 Subunit, supplied by NeuroMab, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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af3667  (R&D Systems)
97
R&D Systems af3667
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
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shrnas antibodies against sox17  (R&D Systems)
96
R&D Systems shrnas antibodies against sox17
Acacetin improves gastrointestinal motility in <t>loperamide‐induced</t> constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
Shrnas Antibodies Against Sox17, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Acacetin improves gastrointestinal motility in loperamide‐induced constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Journal: Neurogastroenterology and Motility

Article Title: Acacetin Alleviates Loperamide‐Induced Functional Constipation by Inhibiting P53 ‐Mediated Apoptosis in Colonic Epithelial Cells

doi: 10.1111/nmo.70298

Figure Lengend Snippet: Acacetin improves gastrointestinal motility in loperamide‐induced constipation model. A loperamide‐induced constipation model was established in mice, different doses of acacetin were administered to the mice by oral gavaging (YWL‐high: 50 mg/kg/day; YWL‐medium: 25 mg/kg/day; YWL‐low: 10 mg/kg/day). The following parameters were monitored in an activated charcoal test after fasting treatment. (A‐D) Defecation initiation time; Fecal pellet counts at 8 h; Fecal water content; and intestinal propulsion rates. (E) Small intestine length measurements. (F) Gastrointestinal transit rates determined by activated charcoal propulsion. N = 6 animals in each group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Article Snippet: A loperamide‐induced functional constipation mouse model was established using oral gavaging of loperamide hydrochloride (HY‐B0418A, MedChemExpress, Shanghai, China) suspension [ , ].

Techniques:

Loperamide activates P53 signaling and reduces AKT1 activation, inducing apoptosis in colonic mucosal epithelial cells. (A) Cell viability analysis after loperamide treatment by CCK‐8 assay in colonic mucosal epithelial cells. (B) TUNEL staining showing apoptotic cells after loperamide treatment. (C) Immunoblotting of cleaved caspase‐3 and Bax expression. (D) Immunoblotting of phosphorylated and total P53 and AKT1 proteins. N = 3 independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Journal: Neurogastroenterology and Motility

Article Title: Acacetin Alleviates Loperamide‐Induced Functional Constipation by Inhibiting P53 ‐Mediated Apoptosis in Colonic Epithelial Cells

doi: 10.1111/nmo.70298

Figure Lengend Snippet: Loperamide activates P53 signaling and reduces AKT1 activation, inducing apoptosis in colonic mucosal epithelial cells. (A) Cell viability analysis after loperamide treatment by CCK‐8 assay in colonic mucosal epithelial cells. (B) TUNEL staining showing apoptotic cells after loperamide treatment. (C) Immunoblotting of cleaved caspase‐3 and Bax expression. (D) Immunoblotting of phosphorylated and total P53 and AKT1 proteins. N = 3 independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Article Snippet: A loperamide‐induced functional constipation mouse model was established using oral gavaging of loperamide hydrochloride (HY‐B0418A, MedChemExpress, Shanghai, China) suspension [ , ].

Techniques: Activation Assay, CCK-8 Assay, TUNEL Assay, Staining, Western Blot, Expressing

YWL extract and acacetin protect against loperamide‐induced apoptosis in colonic mucosal epithelial cells. (A) Cell viability after treatment with increasing doses of YWL extract. (B) Cell viability after treatment with increasing doses of acacetin. (C) Cell viability rescue by YWL extract and acacetin against loperamide‐induced toxicity. (D) TUNEL staining showing suppression of loperamide‐induced apoptosis by YWL and acacetin. (E) Immunoblots of cleaved caspase‐3 and Bax levels. (F) Immunoblots of phospho‐ and total P53 and AKT1 levels. (G) P53 transcriptional activity analysis. N = 3 independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Journal: Neurogastroenterology and Motility

Article Title: Acacetin Alleviates Loperamide‐Induced Functional Constipation by Inhibiting P53 ‐Mediated Apoptosis in Colonic Epithelial Cells

doi: 10.1111/nmo.70298

Figure Lengend Snippet: YWL extract and acacetin protect against loperamide‐induced apoptosis in colonic mucosal epithelial cells. (A) Cell viability after treatment with increasing doses of YWL extract. (B) Cell viability after treatment with increasing doses of acacetin. (C) Cell viability rescue by YWL extract and acacetin against loperamide‐induced toxicity. (D) TUNEL staining showing suppression of loperamide‐induced apoptosis by YWL and acacetin. (E) Immunoblots of cleaved caspase‐3 and Bax levels. (F) Immunoblots of phospho‐ and total P53 and AKT1 levels. (G) P53 transcriptional activity analysis. N = 3 independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Article Snippet: A loperamide‐induced functional constipation mouse model was established using oral gavaging of loperamide hydrochloride (HY‐B0418A, MedChemExpress, Shanghai, China) suspension [ , ].

Techniques: TUNEL Assay, Staining, Western Blot, Activity Assay

Activating P53 signaling abrogates the protection of acacetin against loperamide‐induced apoptosis. (A) P53 transcriptional activity analysis after Nutlin‐3a treatment. (B) Immunoblotting of phospho‐P53 and phospho‐AKT1 levels. (C) Cell viability analysis by CCK‐8 assay showing abrogation of the protective effect of acacetin by Nutlin‐3a. (D) TUNEL staining demonstrating Nutlin‐3a abolishes the suppression of acacetin on loperamide‐induced apoptosis. N = 3 independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Journal: Neurogastroenterology and Motility

Article Title: Acacetin Alleviates Loperamide‐Induced Functional Constipation by Inhibiting P53 ‐Mediated Apoptosis in Colonic Epithelial Cells

doi: 10.1111/nmo.70298

Figure Lengend Snippet: Activating P53 signaling abrogates the protection of acacetin against loperamide‐induced apoptosis. (A) P53 transcriptional activity analysis after Nutlin‐3a treatment. (B) Immunoblotting of phospho‐P53 and phospho‐AKT1 levels. (C) Cell viability analysis by CCK‐8 assay showing abrogation of the protective effect of acacetin by Nutlin‐3a. (D) TUNEL staining demonstrating Nutlin‐3a abolishes the suppression of acacetin on loperamide‐induced apoptosis. N = 3 independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

Article Snippet: A loperamide‐induced functional constipation mouse model was established using oral gavaging of loperamide hydrochloride (HY‐B0418A, MedChemExpress, Shanghai, China) suspension [ , ].

Techniques: Activity Assay, Western Blot, CCK-8 Assay, TUNEL Assay, Staining