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Med Associates Inc
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World Precision Instruments
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UGO Basile S.R.L
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Sage Science
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Coherent Corp
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ADInstruments
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ADInstruments
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ADInstruments
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AutoMate Scientific Inc
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PLUX Biosignals SA
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AutoMate Scientific Inc
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Siemens AG
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Image Search Results
Journal: Frontiers in cellular neuroscience
Article Title: Alterations of Electrophysiological Properties and Ion Channel Expression in Prefrontal Cortex of a Mouse Model of Schizophrenia.
doi: 10.3389/fncel.2019.00554
Figure Lengend Snippet: FIGURE 1 | MIA-SI animals develop schizophrenia-like behaviors, including deficits in jumping behavior, social novelty preference, working memory and sensorimotor gating function. (A) Overview of the experimental design. OFT, open field test; SIT, social interaction test; RAM, radial arm maze; PPI, prepulse inhibition. (B) Total distance traveled was not changed by MIA-SI in OFT. (C) Increased jumping time was observed in MIA-SI animals in OFT. (D) Top, time spent in the non-social chamber (inanimate) versus the social chamber (stranger 1) during the sociability session in SIT, indicating MIA-SI didn’t affect sociability. Bottom, time spent in the chamber with familiar mouse (stranger 1) versus that with novel mouse (stranger 2) during social novelty preference session in SIT, suggesting MIA-SI caused deficit in social novelty preference. (E) Working memory errors committed across five test days in RAM test. (F) Average daily working memory errors over five test days was increased in MIA-SI animals. (G) Time to complete the trial across five test days in RAM test. (H) PPI deficits following poly I:C challenge and isolation rearing. ∗p < 0.05; ∗∗∗p < 0.001. Control, n = 7; MIA-SI, n = 8.
Article Snippet:
Techniques: Inhibition, Isolation, Control