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Purified anti-PSD-93 (Chapsyn-110) [N18/28]; Isotype: Mouse IgG2a; Reactivity: Human, Mouse, Rat; Apps: WB, IHC; Size: 100 μl
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Image Search Results
Journal: bioRxiv
Article Title: Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice
doi: 10.1101/2025.06.04.657776
Figure Lengend Snippet: A) Barplot of DEG counts across bulk RNA-seq experiments (constitutive Chd8 +/- , Camk2a-CRE conditional Chd8 +/flox , and nuclear and synaptosomal preparations from the Chd8 +/- line. B) Chd8 is down-regulated in all but the nuclear preparation. C) LogFC concordance between constitutive and conditional datasets for constitutive model DEGs. D) LogFC concordance plots for nuclear and synaptosomal versus whole cortex for DEGs identified in nulear or synaptosomal fractions on left, reduced concordance between nuclear and synapsomal DEG logFC on right. E) Selected enriched GO terms for upregulated (left) and downregulated (right) genes across experiments. F) Downregulation of Dlg2 in synaptosomal RNA. GH) Western blot validating decreased synaptosomal PSD93 protein in Chd8 +/- cortex.
Article Snippet:
Techniques: RNA Sequencing, Western Blot