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Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity observed in animal studies. Alaproclate
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Image Search Results
Journal: BMC Bioinformatics
Article Title: ProClaT, a new bioinformatics tool for in silico protein reclassification: case study of DraB, a protein coded from the draTGB operon in Azospirillum brasilense
doi: 10.1186/s12859-016-1338-5
Figure Lengend Snippet: Features of the ProClaT pattern recognition model
Article Snippet: As shown in Table ,
Techniques: Sequencing, Functional Assay
Journal: BMC Bioinformatics
Article Title: ProClaT, a new bioinformatics tool for in silico protein reclassification: case study of DraB, a protein coded from the draTGB operon in Azospirillum brasilense
doi: 10.1186/s12859-016-1338-5
Figure Lengend Snippet: Flowchart representing the algorithm to develop ProClaT. In the first step, the domain conserved protein and the consensus region are generated. In the second step, a search is performed in NCBI NR with the generated region consensus as query. With the list of similar proteins, the features are extracted and the classifier is trained and tested
Article Snippet: As shown in Table ,
Techniques: Generated
Journal: BMC Bioinformatics
Article Title: ProClaT, a new bioinformatics tool for in silico protein reclassification: case study of DraB, a protein coded from the draTGB operon in Azospirillum brasilense
doi: 10.1186/s12859-016-1338-5
Figure Lengend Snippet: Original annotation of all complete genome NifO-like proteins. Of the 82 proteins classified as NifO-like with ProClaT, most correspond to nitrogenase-associated protein. The proteins annotated as arsenate reductase, hypothetical and others, totaling 21 proteins, might be re-classified as NifO-like, also
Article Snippet: As shown in Table ,
Techniques:
Journal: BMC Bioinformatics
Article Title: ProClaT, a new bioinformatics tool for in silico protein reclassification: case study of DraB, a protein coded from the draTGB operon in Azospirillum brasilense
doi: 10.1186/s12859-016-1338-5
Figure Lengend Snippet: Bacterial species containing gene coding for NifO-like and for Nif proteins. ProClaT identified 56 bacterial species containing genes coding for nifO-like. All belong to a genome containing at least three genes coding for an essential Nif protein. Fifty-three species contain at least 4 nif genes, 49 contain at least 5 nif genes and 42 contain all the six essential nif genes
Article Snippet: As shown in Table ,
Techniques:
Journal: BMC Bioinformatics
Article Title: ProClaT, a new bioinformatics tool for in silico protein reclassification: case study of DraB, a protein coded from the draTGB operon in Azospirillum brasilense
doi: 10.1186/s12859-016-1338-5
Figure Lengend Snippet: Sensitivity and specificity of protein prediction methods
Article Snippet: As shown in Table ,
Techniques:
Journal: BMC Bioinformatics
Article Title: ProClaT, a new bioinformatics tool for in silico protein reclassification: case study of DraB, a protein coded from the draTGB operon in Azospirillum brasilense
doi: 10.1186/s12859-016-1338-5
Figure Lengend Snippet: NifHDKENB proteins identification by ProClaT
Article Snippet: As shown in Table ,
Techniques: