prkn Search Results


gene exp park2 mm00450187 m1  (Thermo Fisher)
98
Thermo Fisher gene exp park2 mm00450187 m1
Gene Exp Park2 Mm00450187 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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n dykddddk flag tag  (Sino Biological)
91
Sino Biological n dykddddk flag tag
N Dykddddk Flag Tag, supplied by Sino Biological, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit anti p62  (Proteintech)
96
Proteintech rabbit anti p62
Rabbit Anti P62, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp park2 hs00247755 m1  (Thermo Fisher)
85
Thermo Fisher gene exp park2 hs00247755 m1
Gene Exp Park2 Hs00247755 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp park2 hs01038318 m1  (Thermo Fisher)
92
Thermo Fisher gene exp park2 hs01038318 m1
a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; <t>PARK2</t> knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.
Gene Exp Park2 Hs01038318 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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rabbit anti parkin monoclonal antibody  (Boster Bio)
90
Boster Bio rabbit anti parkin monoclonal antibody
a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; <t>PARK2</t> knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.
Rabbit Anti Parkin Monoclonal Antibody, supplied by Boster Bio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prkn hs01038318 mrna  (Thermo Fisher)
86
Thermo Fisher prkn hs01038318 mrna
a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; <t>PARK2</t> knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.
Prkn Hs01038318 Mrna, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
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copy number variation park2 hs00089553 cn  (Thermo Fisher)
86
Thermo Fisher copy number variation park2 hs00089553 cn
a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; <t>PARK2</t> knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.
Copy Number Variation Park2 Hs00089553 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
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park2 sequence  (Sino Biological)
92
Sino Biological park2 sequence
a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; <t>PARK2</t> knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.
Park2 Sequence, supplied by Sino Biological, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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parkin  (OriGene)
90
OriGene parkin
a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; <t>PARK2</t> knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.
Parkin, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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copy number variation park2 hs00134402 cn  (Thermo Fisher)
86
Thermo Fisher copy number variation park2 hs00134402 cn
a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; <t>PARK2</t> knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.
Copy Number Variation Park2 Hs00134402 Cn, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit polyclonal igg  (Proteintech)
96
Proteintech rabbit polyclonal igg
a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; <t>PARK2</t> knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.
Rabbit Polyclonal Igg, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; PARK2 knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.

Journal: Nature Communications

Article Title: Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

doi: 10.1038/s41467-024-45044-1

Figure Lengend Snippet: a Representative images of ARPE-19 cells expressing the mito -QC reporter which subjected to PINK1/Parkin-depedent mitophagy ( PINK1; PARK2 knockdown) and/or mitochondrial biogenesis (100 μM Chloramphenicol) inhibition, and simultaneously treated with ABT-737 and/or UA. b Quantification of the number of mitolysosomes per cell as shown in Fig. 7a ( n = 4 independent experiments). c Quantification of mitochondrial mass in the presence or absence of Chloramphenicol to validate UA-induced mitochondrial biogenesis inhibition, as reported in Fig. ( n = 4 independent experiments). d Representative images showing immunostaining of ARPE-19 cells for DNA (green) and TOMM20 (magenta, mitochondria). e Quantification of the number of cytosolic DNA foci per cell as shown in Fig. 7d ( n = 4 independent experiments). f Quantification of PINK1 and PARK2 mRNA levels to validate siRNA-mediated knockdown efficiency ( n = 4 independent experiments). Scale bars, 25 μm. All data are expressed as the mean ± s.e.m. Dots represent independent experiments. P values were calculated using two-tailed Student’s t test ( b , c ) or two-tailed Mann–Whitney’s U -test ( b , Control:Control vs Control:ABT), 1-way ANOVA with Šídák’s post-hoc test ( e ) or 2-way ANOVA with Šídák’s post-hoc test ( f ). Source data are provided as a Source Data file.

Article Snippet: Knockdown efficiency was validated by RT-qPCR using TaqMan probes (Thermo Fisher) targeting PINK1 (Hs00260868_m1) or PARK2 (Hs01038318_m1), and ribosomal 18S (Hs99999901_s1) was used as reference gene.

Techniques: Expressing, Knockdown, Inhibition, Immunostaining, Two Tailed Test, Control