Journal: Expert opinion on drug discovery

Article Title: Redirecting the revolution: New developments in drug development for psychiatry

doi: 10.1080/17460441.2019.1666102

Figure Lengend Snippet: Psychiatric Drug Pipeline (2013-2019) 1

Article Snippet: pimavanserin (NuplaxidTM) , 5-HT2A receptor inverse agonist, less so at 5-HT2C receptor , hallucinations and delusions in Parkinson’s disease psychosis , Acadia Pharmaceuticals Inc. , Apr. 2016.

Techniques: Clinical Proteomics, Biomarker Discovery, Injection, Cannabis

Journal: Psychopharmacology

Article Title: Spontaneous head twitches in aged rats: behavioral and molecular study

doi: 10.1007/s00213-022-06253-y

Figure Lengend Snippet: Effect of haloperidol, F(3, 28) = 0.94; P > 0.05 ( A ), amisulpride, F(4, 35) = 1.79; P > 0.05 ( B ), olanzapine, F(3, 28) = 11.20; P < 0.01 ( C ), clozapine, F(3, 28) = 12.49, P < 0.01 ( D ), risperidone, F(5, 41) = 5.39; P < 0.01 ( E ), pimavanserin, F(3, 28) = 3.92; P < 0.05 ( F ), and escitalopram, F(3, 28) = 2.28, P > 0.05 ( G ) on the number of SHT (spontaneous head Twitches) in the group of HSHT (high spontaneous head twitching) rats. The results are presented as the mean ± SEM. * P < 0.05, ** P < 0.01, Newman-Keuls post hoc test

Article Snippet: Haloperidol (Polfa Warszawa S.A., Poland) was dissolved in 0.9% NaCl and administered s.c. at doses of 0.01, 0.03, and 0.1 mg/kg in a volume of 1.0 ml/kg 60 min before the test; amisulpride (Cayman) was suspended in a 1.5% aqueous solution of Tween 80 (Sigma-Aldrich) and administered i.p. at doses of 1.0, 3.0, 10.0, and 30.0 mg/kg in a volume of 2.0 ml/kg 60 min before testing; olanzapine (Cayman) was suspended in a 1.5% aqueous solution of Tween 80 (Sigma-Aldrich) and administered i.p. at doses of 0.1, 0.3, and 1.0 mg/kg in a volume of 2.0 ml/kg 60 min before testing; clozapine (Sigma-Aldrich) was dissolved in a 1.5% aqueous solution of Tween 80 with a few drops of acetic acid and administered i.p. at doses of 0.3, 1.0, and 3.0 mg/kg in a volume of 3 ml/kg 60 min before the test; risperidone (Cayman) was suspended in a 1.5% aqueous solution of Tween 80 and administered i.p. at doses of 0.1, 0.3, and 1.0 mg/kg in a volume of 1.0 ml/kg 60 min before testing; pimavanserin (Cayman) was dissolved in 0.9% NaCl and administrated i.p. at doses of 1.0, 3.0, and 10.0 mg/kg in a volume of 2.0 ml/kg 60 min before the experiment; escitalopram (Sigma-Aldrich) was dissolved in physiological saline and administrated i.p. at doses of 1.0, 3.0, and 10 mg/kg in a volume of 2.0 ml/kg 60 min before the test.

Techniques: