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Image Search Results
Journal: Cancers
Article Title: Anticancer Effect of Heparin–Taurocholate Conjugate on Orthotopically Induced Exocrine and Endocrine Pancreatic Cancer
doi: 10.3390/cancers13225775
Figure Lengend Snippet: Inhibition effect of LHT on the cellular proliferation and migration through VEGF receptor, ERK and FAK pathways. ( A ) Multiple signaling pathways from the VEGF-A/VEGFR2 interaction to induce cellular migration and proliferation. LHT inhibits VEGF-A/VEGFR2 binding through VEGF-A/LHT interactions. ( B ) Western blot (cropped blots) of cell lysate of HUVECs after cultivation with VEGF (10 ng/mL) or VEGF with LHT (100 µg/mL) for 24 h. Full-length blots were presented in . ( C ) Quantitative analysis of Western blotting bands cell lysate of HUVECs after cultivation with VEGF (10 ng/mL) or VEGF with LHT (100 µg/mL) for 24 h. Data were expressed with mean ± s.e.m. (n = 3). * p < 0.05, *** p < 0.001 versus the VEGF-treated group.
Article Snippet: Then, Western blotting was carried out for checking the phosphorylation of VEGFR, ERK1/2 and
Techniques: Inhibition, Migration, Protein-Protein interactions, Binding Assay, Western Blot