pf1022a Search Results


pf1022a  (MedChemExpress)
90
MedChemExpress pf1022a
Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus <t>PF1022A</t> (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).
Pf1022a, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf1022a  (Chemie GmbH)
90
Chemie GmbH pf1022a
Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus <t>PF1022A</t> (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).
Pf1022a, supplied by Chemie GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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organism—m. sterilia pf1022  (Meiji Seika Pharma Co Ltd)
90
Meiji Seika Pharma Co Ltd organism—m. sterilia pf1022
Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus <t>PF1022A</t> (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).
Organism—M. Sterilia Pf1022, supplied by Meiji Seika Pharma Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anthelmintic cyclodepsipeptide, pf1022a  (Makoto USA Inc)
90
Makoto USA Inc anthelmintic cyclodepsipeptide, pf1022a
Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus <t>PF1022A</t> (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).
Anthelmintic Cyclodepsipeptide, Pf1022a, supplied by Makoto USA Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bis-morpholino derivative of pf1022a  (Fujisawa Pharmaceutical Co Ltd)
90
Fujisawa Pharmaceutical Co Ltd bis-morpholino derivative of pf1022a
Chemical structures of the semisynthetic emodepside (A) and its precursor <t>PF1022A</t> (B) purified from Rosellinia spp. PF1022.
Bis Morpholino Derivative Of Pf1022a, supplied by Fujisawa Pharmaceutical Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bis-morpholino derivative of pf1022a/product/Fujisawa Pharmaceutical Co Ltd
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pf1022a  (Bayer AG)
90
Bayer AG pf1022a
Chemical structures of the semisynthetic emodepside (A) and its precursor <t>PF1022A</t> (B) purified from Rosellinia spp. PF1022.
Pf1022a, supplied by Bayer AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cyclooctadepsipeptide pf1022a  (Mimetics)
90
Mimetics cyclooctadepsipeptide pf1022a
Chemical structures of the semisynthetic emodepside (A) and its precursor <t>PF1022A</t> (B) purified from Rosellinia spp. PF1022.
Cyclooctadepsipeptide Pf1022a, supplied by Mimetics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pf1022a  (Bayer Cropscience Deutschland GmbH)
90
Bayer Cropscience Deutschland GmbH pf1022a
Chemical structures of the semisynthetic emodepside (A) and its precursor <t>PF1022A</t> (B) purified from Rosellinia spp. PF1022.
Pf1022a, supplied by Bayer Cropscience Deutschland GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pf1022a/product/Bayer Cropscience Deutschland GmbH
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cyclic depsipeptide pf1022a  (Pfizer Inc)
90
Pfizer Inc cyclic depsipeptide pf1022a
Chemical structures of the semisynthetic emodepside (A) and its precursor <t>PF1022A</t> (B) purified from Rosellinia spp. PF1022.
Cyclic Depsipeptide Pf1022a, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus PF1022A (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).

Journal: Biomedicines

Article Title: The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability

doi: 10.3390/biomedicines9040369

Figure Lengend Snippet: Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus PF1022A (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).

Article Snippet: GAL-021 and PF1022A were acquired from MedChemExpress (Everything Biotech, New Taipei City, Taiwan); cilobradine was obtained from Cayman (Excel Biomedical, Taipei, Taiwan); 2-chloro-α, α-diphenylbenzeneacetonitrile (TRAM39) was obtained from Tocris (Union Biomed Inc., Taipei, Taiwan), and tefluthrhin, tetraethylammonium chloride and tetrodotoxin were obtained from Sigma-Aldrich (Merck Ltd., Taipei, Taiwan).

Techniques: Activity Assay, Control, Membrane

Chemical structures of the semisynthetic emodepside (A) and its precursor PF1022A (B) purified from Rosellinia spp. PF1022.

Journal: PLoS Pathogens

Article Title: Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration

doi: 10.1371/journal.ppat.1009682

Figure Lengend Snippet: Chemical structures of the semisynthetic emodepside (A) and its precursor PF1022A (B) purified from Rosellinia spp. PF1022.

Article Snippet: A patent application was subsequently filed by Fujisawa Pharmaceutical for a bis-morpholino derivative of PF1022A, which was later named emodepside [ ].

Techniques: Purification