Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Physiologically based pharmacokinetic model of cis - and trans -permethrin in pregnant rats and fetuses.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques:

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Physiological parameters of the maternal and fetal physiologically based pharmacokinetic models for cis - and trans -permethrin.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques: Proximity Ligation Assay

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Distribution of the chemical specific parameters of the model for permethrin isomers in pregnant rats and fetuses.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques: Proximity Ligation Assay, Permeability

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Measured concentrations (squares) and toxicokinetic profiles estimated with the physiologically based pharmacokinetic model (solid line) of cis -permethrin in pregnant rats at GD1, GD15, and GD20. The gray dotted line stands for the limit of quantification.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques:

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Measured concentrations (dots) and toxicokinetic profiles estimated with the physiologically based pharmacokinetic model (solid line) of trans -permethrin in pregnant rats at GD1, GD15, and GD20. The gray dotted line stands for the limit of quantification.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques:

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Measured concentrations of cis- permethrin (squares) and trans- permethrin (dots) and toxicokinetic profiles estimated with the physiologically based pharmacokinetic model (solid lines) in the placenta (A) and fetal tissues (B) . Mean values ± SD for n = 4 at each time point except for the point marked with an asterisk ( n = 1). The gray dotted line stands for the limit of quantification.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques:

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Maximum time concentration ( T max , h)/half-lives ( T 1/2 , h) of cis - and trans -permethrin in the blood and tissues of pregnant rats at GD1, GD15, and GD20.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques: Concentration Assay

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Area under the curve (μg h/ml or μg h/g) of the observed concentrations (AUC obs ) and the estimated concentrations (AUC est ) for cis -permethrin in the blood and tissues of pregnant rats.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques:

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Area under the curve (μg h/ml or μg h/g) of the observed concentrations (AUC obs ) and the estimated concentrations (AUC est ) for trans -permethrin in the blood and tissues of pregnant rats.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques:

Journal: Frontiers in Pediatrics

Article Title: Evaluation of Placental Transfer and Tissue Distribution of cis - and Trans -Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

doi: 10.3389/fped.2021.730383

Figure Lengend Snippet: Area under the curve (μg h/ml or μg h/g) of the observed concentrations (AUC obs ) and the estimated concentrations (AUC est ) for cis -permethrin in fetal blood, liver, and brain.

Article Snippet: The internal standards, 13 C 6 - cis -permethrin and 13 C 6− trans -permethrin, were purchased from Cambridge Isotope Laboratories (Andover, MA, USA).

Techniques: