Journal: Biomedical chromatography : BMC

Article Title: Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography - mass spectrometry

doi: 10.1002/bmc.2873

Figure Lengend Snippet: Product ion spectra of famotidine [M+H]+ .

Article Snippet: Chemicals All chemicals were purchased from the following companies: famotidine, Sigma Chemical Co. (St. Louis, MO); the internal standard 13 C 3 -famotidine, Toronto Research Chemicals, Inc. (North York, Canada); HPLC-grade acetonitrile, ammonium hydroxide, ethyl acetate and ammonium acetate, Fisher Scientific (Fair Lawn, NJ).

Techniques:

Journal: Biomedical chromatography : BMC

Article Title: Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography - mass spectrometry

doi: 10.1002/bmc.2873

Figure Lengend Snippet: The selected ion monitoring (SIM) chromatograms for the determination of famotidine in samples of maternal plasma (A1-A3), umbilical cord plasma (B1-B3) and urine (C1-C3): (A1) chromatogram of blank maternal plasma; (A2) chromatogram of blank maternal plasma spiked with famotidine (6.31 ng/mL); (A3) maternal plasma of a pregnant patient under treatment with 20 mg famotidine (b.i.d.); (B1) chromatogram of blank umbilical cord plasma; (B2) chromatogram of blank umbilical cord plasma spiked with famotidine (6.31 ng/mL); (B3) umbilical cord plasma following delivery from a pregnant patient under treatment with 20 mg famotidine (b.i.d.); (C1) chromatogram of blank urine sample; (C2) chromatogram of blank urine sample spiked with famotidine (750 ng/mL); (C3) urine sample of a pregnant patient under treatment with 20 mg famotidine (b.i.d.).

Article Snippet: Chemicals All chemicals were purchased from the following companies: famotidine, Sigma Chemical Co. (St. Louis, MO); the internal standard 13 C 3 -famotidine, Toronto Research Chemicals, Inc. (North York, Canada); HPLC-grade acetonitrile, ammonium hydroxide, ethyl acetate and ammonium acetate, Fisher Scientific (Fair Lawn, NJ).

Techniques: Clinical Proteomics

Journal: Biomedical chromatography : BMC

Article Title: Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography - mass spectrometry

doi: 10.1002/bmc.2873

Figure Lengend Snippet: Extraction recovery of famotidine in maternal and umbilical cord plasma samples (n=3).

Article Snippet: Chemicals All chemicals were purchased from the following companies: famotidine, Sigma Chemical Co. (St. Louis, MO); the internal standard 13 C 3 -famotidine, Toronto Research Chemicals, Inc. (North York, Canada); HPLC-grade acetonitrile, ammonium hydroxide, ethyl acetate and ammonium acetate, Fisher Scientific (Fair Lawn, NJ).

Techniques: Extraction, Clinical Proteomics, Concentration Assay

Journal: Biomedical chromatography : BMC

Article Title: Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography - mass spectrometry

doi: 10.1002/bmc.2873

Figure Lengend Snippet: Matrix effect factor of famotidine in maternal plasma, umbilical cord plasma and urine samples (n=6).

Article Snippet: Chemicals All chemicals were purchased from the following companies: famotidine, Sigma Chemical Co. (St. Louis, MO); the internal standard 13 C 3 -famotidine, Toronto Research Chemicals, Inc. (North York, Canada); HPLC-grade acetonitrile, ammonium hydroxide, ethyl acetate and ammonium acetate, Fisher Scientific (Fair Lawn, NJ).

Techniques: Clinical Proteomics, Concentration Assay

Journal: Biomedical chromatography : BMC

Article Title: Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography - mass spectrometry

doi: 10.1002/bmc.2873

Figure Lengend Snippet: Calibration curves of famotidine in maternal plasma, umbilical cord plasma and urine samples (n=3).

Article Snippet: Chemicals All chemicals were purchased from the following companies: famotidine, Sigma Chemical Co. (St. Louis, MO); the internal standard 13 C 3 -famotidine, Toronto Research Chemicals, Inc. (North York, Canada); HPLC-grade acetonitrile, ammonium hydroxide, ethyl acetate and ammonium acetate, Fisher Scientific (Fair Lawn, NJ).

Techniques: Clinical Proteomics

Journal: Biomedical chromatography : BMC

Article Title: Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography - mass spectrometry

doi: 10.1002/bmc.2873

Figure Lengend Snippet: Stability of famotidine in maternal plasma, umbilical cord plasma and urine samples (n=3).

Article Snippet: Chemicals All chemicals were purchased from the following companies: famotidine, Sigma Chemical Co. (St. Louis, MO); the internal standard 13 C 3 -famotidine, Toronto Research Chemicals, Inc. (North York, Canada); HPLC-grade acetonitrile, ammonium hydroxide, ethyl acetate and ammonium acetate, Fisher Scientific (Fair Lawn, NJ).

Techniques: Clinical Proteomics, Concentration Assay

Journal: Biomedical chromatography : BMC

Article Title: Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high-performance liquid chromatography - mass spectrometry

doi: 10.1002/bmc.2873

Figure Lengend Snippet: Representative (A) famotidine plasma concentration-time profiles, (B) concentration of famotidine in maternal, umbilical venous and arterial plasma at delivery, and (C) famotidine urine concentration-time profile in pregnant patients (n=3) prescribed famotidine (20 mg orally, b.i.d.). The blood (A) and urine (C) were collected from late gestation pregnant patients under steady-state conditions. It should be noted that no plasma samples were collected from Subject No. 1 at the time of delivery.

Article Snippet: Chemicals All chemicals were purchased from the following companies: famotidine, Sigma Chemical Co. (St. Louis, MO); the internal standard 13 C 3 -famotidine, Toronto Research Chemicals, Inc. (North York, Canada); HPLC-grade acetonitrile, ammonium hydroxide, ethyl acetate and ammonium acetate, Fisher Scientific (Fair Lawn, NJ).

Techniques: Clinical Proteomics, Concentration Assay

Journal: Scientific Reports

Article Title: NanoBRET binding assay for histamine H 2 receptor ligands using live recombinant HEK293T cells

doi: 10.1038/s41598-020-70332-3

Figure Lengend Snippet: Binding data (p K i values) of histamine ( 1 ), cimetidine ( 2 ), ranitidine ( 3 ), famotidine ( 4 ), UR-Po444 ( 11 ) and UR-Po448 ( 12 ) determined at the human H 2 R in the NanoBRET binding assay and radioligand competition binding assays.

Article Snippet: Famotidine and ranitidine hydrochloride were from Tocris Bioscience (Ellisville, MO, USA).

Techniques: Binding Assay

Journal: The Journal of Neuroscience

Article Title: Ionotropic Histamine Receptors and H 2 Receptors Modulate Supraoptic Oxytocin Neuronal Excitability and Dye Coupling

doi: 10.1523/JNEUROSCI.21-09-02974.2001

Figure Lengend Snippet: GDP-βS blockade of G-protein pathways.Top trace, Spontaneous activity before and after intracellular 3 min injection (-//-) of GDP-βS. No effect was observed on the IPSPs (insets), although HA inhibited firing. Middle trace, The H2 receptor antagonist famotidine reinstated firing and blocked the IPSPs.Bottom trace, Washout reversed the effects.

Article Snippet: Drugs used were as follows: Rp-adenosine 3′,5′-cyclic monophosphothioate triethylamine (Rp-cAMPs), an inhibitor of activation by cAMP of cAMP-dependent protein kinase A (PKA), and Sp-adenosine 3′,5′-cyclic monophosphothioate triethylamine (Sp-cAMPs), activator of PKA (both from Research Biochemicals, Natick, MA); cAMP; 8-bromo-cAMP; the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX); pertussis toxin; pyrilamine, an H 1 receptor antagonist; the H 2 antagonists cimetidine and famotidine; and clobenpropit dihydrobromide, an H 3 receptor antagonist (Tocris Cookson, Ballwin, MO).

Techniques: Activity Assay, Injection

Journal: The Journal of Neuroscience

Article Title: Ionotropic Histamine Receptors and H 2 Receptors Modulate Supraoptic Oxytocin Neuronal Excitability and Dye Coupling

doi: 10.1523/JNEUROSCI.21-09-02974.2001

Figure Lengend Snippet: Pertussis toxin blockade of G-protein pathways.Top trace, Cell #2858. Spontaneous continuous firing.A, B, IPSPs in control medium and with pertussis toxin (PTX) after a 5 min incubation.C, IPSP blockade by the H2 receptor antagonist famotidine. D, Washout of antagonist with medium containing PTX. E–G, Cell #2856.E, Evoked IPSPs in medium with PTX. F, Blockade of IPSPs by cimetidine. G, Reinstated upon washout with PTX-containing medium. A–G, Five traces averaged in each case.

Article Snippet: Drugs used were as follows: Rp-adenosine 3′,5′-cyclic monophosphothioate triethylamine (Rp-cAMPs), an inhibitor of activation by cAMP of cAMP-dependent protein kinase A (PKA), and Sp-adenosine 3′,5′-cyclic monophosphothioate triethylamine (Sp-cAMPs), activator of PKA (both from Research Biochemicals, Natick, MA); cAMP; 8-bromo-cAMP; the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX); pertussis toxin; pyrilamine, an H 1 receptor antagonist; the H 2 antagonists cimetidine and famotidine; and clobenpropit dihydrobromide, an H 3 receptor antagonist (Tocris Cookson, Ballwin, MO).

Techniques: Control, Incubation

Journal: The Journal of Neuroscience

Article Title: Ionotropic Histamine Receptors and H 2 Receptors Modulate Supraoptic Oxytocin Neuronal Excitability and Dye Coupling

doi: 10.1523/JNEUROSCI.21-09-02974.2001

Figure Lengend Snippet: Comparisons of the incidence of coupling under a variety of experimental conditions. TM stimulation (TM Stim; n = 15 injections) reduced coupling to 20% of unstimulated control (Control No Stim;n = 11), an effect abolished by two different H2 receptor antagonists, cimetidine (Cimet;n = 10), which had no effect by itself (Cimet No Stim; n = 9), or famotidine (Famot; n = 13). Neither pyrilamine (H1 Ant;n = 16) nor clobenpropit (H3 Ant; n = 18) was effective in preventing the effects of TM stimulation. * indicates significantly different at p < 0.05 top > 0.03 from Control No Stim.

Article Snippet: Drugs used were as follows: Rp-adenosine 3′,5′-cyclic monophosphothioate triethylamine (Rp-cAMPs), an inhibitor of activation by cAMP of cAMP-dependent protein kinase A (PKA), and Sp-adenosine 3′,5′-cyclic monophosphothioate triethylamine (Sp-cAMPs), activator of PKA (both from Research Biochemicals, Natick, MA); cAMP; 8-bromo-cAMP; the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX); pertussis toxin; pyrilamine, an H 1 receptor antagonist; the H 2 antagonists cimetidine and famotidine; and clobenpropit dihydrobromide, an H 3 receptor antagonist (Tocris Cookson, Ballwin, MO).

Techniques: Control

Journal: Calcified Tissue International

Article Title: Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro

doi: 10.1007/s00223-021-00882-9

Figure Lengend Snippet: The effects of histamine-2 receptor antagonists (H2RAs) on PHOSPHO1 activity. PHOSPHO1 activity was assessed by phosphatase assays in the presence of A cimetidine, B ranitidine, C famotidine and D nizatidine

Article Snippet: Similarly, the H2RAs nizatidine, famotidine, cimetidine and ranitidine (Selleckchem, Munich, Germany) were also used at 0-100 μM.

Techniques: Activity Assay

Journal: Journal of Advanced Research

Article Title: A mini-review on drug delivery through wafer technology: Formulation and manufacturing of buccal and oral lyophilizates

doi: 10.1016/j.jare.2019.04.010

Figure Lengend Snippet: Examples of commercial oral lyophilizates (US and EU markets).

Article Snippet: Famotidine (20, 40 mg) , Hearthburn, Indigestion , Pepcidine Rapitab , Cardinal/Merck , Aspartame, mint flavor, gelatin, mannitol, red ferric oxide and xanthan gum.

Techniques:

Journal: Frontiers in Cell and Developmental Biology

Article Title: Recent Advances in Pathophysiology, Drug Development and Future Perspectives of SARS-CoV-2

doi: 10.3389/fcell.2020.580202

Figure Lengend Snippet: Development of SARS-CoV-2 Immunoglobulin based treatments option.

Article Snippet: Pepcid , H2 blocker , Yamanouchi Pharmaceutical Co., Merck, Japan , Phase-III.

Techniques: Clinical Proteomics, Expressing