palosuran Search Results


palosuran  (MedChemExpress)
92
MedChemExpress palosuran
a – e Antagonistic effect of <t>palosuran,</t> GSK1562590 and ligand bias of urantide on the activation of G proteins and β-arrestins on UII-activated UT signaling pathways (3 independent experiments for each in triplicate each). a Using BRET biosensors, UII activation of G i coupled family members Gαi1, Gαi2, Gαi3, and Gαz was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. b The activation of the G q pathway was accessed using both a BRET biosensor and by determining the production levels of the second messenger IP 1 in the presence of 10 µM of the indicated biased ligand/antagonists. c Ca 2+ mobilization induced by graded concentrations (10 −11 to 10 −6 M) of UII on hUT-transfected HEK-293 cells pretreated with buffer or biased ligand/antagonists. d Using BRET biosensors, UII activation of G o coupled family members GoA and GoB was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. e Using BRET biosensors, the UII-induced recruitment of β-arrestin 1 and β-arrestin 2 was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists ( a – e , n = 3; values are expressed as the mean ± SEM). f Timeline of intracisternal injection of palosuran, GSK1562590 or urantide during SAH induction prior to CVS analysis and behavioral testing. g Graphs (right panel) representing changes in lumen area/wall thickness on MCA ( n = 6/condition). Values are expressed as the mean ± SEM. *** P < 0.001 for comparisons with aCSF + sham condition. $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Exploration in OFT (10 min) and sensorimotor functions in BWT ( n = 6–10/condition). Values are expressed as the mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001 for comparisons with aCSF + sham condition. $ P < 0.05; $$ P < 0.01; $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Source data are provided as a Source Data file. f created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license ( https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en ).
Palosuran, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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u-ii receptor antagonist palosuran  (Actelion)
90
Actelion u-ii receptor antagonist palosuran
a – e Antagonistic effect of <t>palosuran,</t> GSK1562590 and ligand bias of urantide on the activation of G proteins and β-arrestins on UII-activated UT signaling pathways (3 independent experiments for each in triplicate each). a Using BRET biosensors, UII activation of G i coupled family members Gαi1, Gαi2, Gαi3, and Gαz was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. b The activation of the G q pathway was accessed using both a BRET biosensor and by determining the production levels of the second messenger IP 1 in the presence of 10 µM of the indicated biased ligand/antagonists. c Ca 2+ mobilization induced by graded concentrations (10 −11 to 10 −6 M) of UII on hUT-transfected HEK-293 cells pretreated with buffer or biased ligand/antagonists. d Using BRET biosensors, UII activation of G o coupled family members GoA and GoB was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. e Using BRET biosensors, the UII-induced recruitment of β-arrestin 1 and β-arrestin 2 was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists ( a – e , n = 3; values are expressed as the mean ± SEM). f Timeline of intracisternal injection of palosuran, GSK1562590 or urantide during SAH induction prior to CVS analysis and behavioral testing. g Graphs (right panel) representing changes in lumen area/wall thickness on MCA ( n = 6/condition). Values are expressed as the mean ± SEM. *** P < 0.001 for comparisons with aCSF + sham condition. $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Exploration in OFT (10 min) and sensorimotor functions in BWT ( n = 6–10/condition). Values are expressed as the mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001 for comparisons with aCSF + sham condition. $ P < 0.05; $$ P < 0.01; $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Source data are provided as a Source Data file. f created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license ( https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en ).
U Ii Receptor Antagonist Palosuran, supplied by Actelion, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
u-ii receptor antagonist palosuran - by Bioz Stars, 2026-03
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palosuran  (Actelion)
90
Actelion palosuran
a – e Antagonistic effect of <t>palosuran,</t> GSK1562590 and ligand bias of urantide on the activation of G proteins and β-arrestins on UII-activated UT signaling pathways (3 independent experiments for each in triplicate each). a Using BRET biosensors, UII activation of G i coupled family members Gαi1, Gαi2, Gαi3, and Gαz was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. b The activation of the G q pathway was accessed using both a BRET biosensor and by determining the production levels of the second messenger IP 1 in the presence of 10 µM of the indicated biased ligand/antagonists. c Ca 2+ mobilization induced by graded concentrations (10 −11 to 10 −6 M) of UII on hUT-transfected HEK-293 cells pretreated with buffer or biased ligand/antagonists. d Using BRET biosensors, UII activation of G o coupled family members GoA and GoB was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. e Using BRET biosensors, the UII-induced recruitment of β-arrestin 1 and β-arrestin 2 was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists ( a – e , n = 3; values are expressed as the mean ± SEM). f Timeline of intracisternal injection of palosuran, GSK1562590 or urantide during SAH induction prior to CVS analysis and behavioral testing. g Graphs (right panel) representing changes in lumen area/wall thickness on MCA ( n = 6/condition). Values are expressed as the mean ± SEM. *** P < 0.001 for comparisons with aCSF + sham condition. $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Exploration in OFT (10 min) and sensorimotor functions in BWT ( n = 6–10/condition). Values are expressed as the mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001 for comparisons with aCSF + sham condition. $ P < 0.05; $$ P < 0.01; $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Source data are provided as a Source Data file. f created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license ( https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en ).
Palosuran, supplied by Actelion, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/palosuran/product/Actelion
Average 90 stars, based on 1 article reviews
palosuran - by Bioz Stars, 2026-03
90/100 stars
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palosuran  (Glaxo Smith)
90
Glaxo Smith palosuran
a – e Antagonistic effect of <t>palosuran,</t> GSK1562590 and ligand bias of urantide on the activation of G proteins and β-arrestins on UII-activated UT signaling pathways (3 independent experiments for each in triplicate each). a Using BRET biosensors, UII activation of G i coupled family members Gαi1, Gαi2, Gαi3, and Gαz was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. b The activation of the G q pathway was accessed using both a BRET biosensor and by determining the production levels of the second messenger IP 1 in the presence of 10 µM of the indicated biased ligand/antagonists. c Ca 2+ mobilization induced by graded concentrations (10 −11 to 10 −6 M) of UII on hUT-transfected HEK-293 cells pretreated with buffer or biased ligand/antagonists. d Using BRET biosensors, UII activation of G o coupled family members GoA and GoB was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. e Using BRET biosensors, the UII-induced recruitment of β-arrestin 1 and β-arrestin 2 was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists ( a – e , n = 3; values are expressed as the mean ± SEM). f Timeline of intracisternal injection of palosuran, GSK1562590 or urantide during SAH induction prior to CVS analysis and behavioral testing. g Graphs (right panel) representing changes in lumen area/wall thickness on MCA ( n = 6/condition). Values are expressed as the mean ± SEM. *** P < 0.001 for comparisons with aCSF + sham condition. $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Exploration in OFT (10 min) and sensorimotor functions in BWT ( n = 6–10/condition). Values are expressed as the mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001 for comparisons with aCSF + sham condition. $ P < 0.05; $$ P < 0.01; $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Source data are provided as a Source Data file. f created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license ( https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en ).
Palosuran, supplied by Glaxo Smith, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/palosuran/product/Glaxo Smith
Average 90 stars, based on 1 article reviews
palosuran - by Bioz Stars, 2026-03
90/100 stars
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palosuran 1  (Actelion)
90
Actelion palosuran 1
a – e Antagonistic effect of <t>palosuran,</t> GSK1562590 and ligand bias of urantide on the activation of G proteins and β-arrestins on UII-activated UT signaling pathways (3 independent experiments for each in triplicate each). a Using BRET biosensors, UII activation of G i coupled family members Gαi1, Gαi2, Gαi3, and Gαz was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. b The activation of the G q pathway was accessed using both a BRET biosensor and by determining the production levels of the second messenger IP 1 in the presence of 10 µM of the indicated biased ligand/antagonists. c Ca 2+ mobilization induced by graded concentrations (10 −11 to 10 −6 M) of UII on hUT-transfected HEK-293 cells pretreated with buffer or biased ligand/antagonists. d Using BRET biosensors, UII activation of G o coupled family members GoA and GoB was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. e Using BRET biosensors, the UII-induced recruitment of β-arrestin 1 and β-arrestin 2 was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists ( a – e , n = 3; values are expressed as the mean ± SEM). f Timeline of intracisternal injection of palosuran, GSK1562590 or urantide during SAH induction prior to CVS analysis and behavioral testing. g Graphs (right panel) representing changes in lumen area/wall thickness on MCA ( n = 6/condition). Values are expressed as the mean ± SEM. *** P < 0.001 for comparisons with aCSF + sham condition. $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Exploration in OFT (10 min) and sensorimotor functions in BWT ( n = 6–10/condition). Values are expressed as the mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001 for comparisons with aCSF + sham condition. $ P < 0.05; $$ P < 0.01; $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Source data are provided as a Source Data file. f created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license ( https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en ).
Palosuran 1, supplied by Actelion, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/palosuran 1/product/Actelion
Average 90 stars, based on 1 article reviews
palosuran 1 - by Bioz Stars, 2026-03
90/100 stars
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Image Search Results


a – e Antagonistic effect of palosuran, GSK1562590 and ligand bias of urantide on the activation of G proteins and β-arrestins on UII-activated UT signaling pathways (3 independent experiments for each in triplicate each). a Using BRET biosensors, UII activation of G i coupled family members Gαi1, Gαi2, Gαi3, and Gαz was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. b The activation of the G q pathway was accessed using both a BRET biosensor and by determining the production levels of the second messenger IP 1 in the presence of 10 µM of the indicated biased ligand/antagonists. c Ca 2+ mobilization induced by graded concentrations (10 −11 to 10 −6 M) of UII on hUT-transfected HEK-293 cells pretreated with buffer or biased ligand/antagonists. d Using BRET biosensors, UII activation of G o coupled family members GoA and GoB was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. e Using BRET biosensors, the UII-induced recruitment of β-arrestin 1 and β-arrestin 2 was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists ( a – e , n = 3; values are expressed as the mean ± SEM). f Timeline of intracisternal injection of palosuran, GSK1562590 or urantide during SAH induction prior to CVS analysis and behavioral testing. g Graphs (right panel) representing changes in lumen area/wall thickness on MCA ( n = 6/condition). Values are expressed as the mean ± SEM. *** P < 0.001 for comparisons with aCSF + sham condition. $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Exploration in OFT (10 min) and sensorimotor functions in BWT ( n = 6–10/condition). Values are expressed as the mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001 for comparisons with aCSF + sham condition. $ P < 0.05; $$ P < 0.01; $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Source data are provided as a Source Data file. f created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license ( https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en ).

Journal: Nature Communications

Article Title: The urotensin II receptor triggers an early meningeal response and a delayed macrophage-dependent vasospasm after subarachnoid hemorrhage in male mice

doi: 10.1038/s41467-024-52654-2

Figure Lengend Snippet: a – e Antagonistic effect of palosuran, GSK1562590 and ligand bias of urantide on the activation of G proteins and β-arrestins on UII-activated UT signaling pathways (3 independent experiments for each in triplicate each). a Using BRET biosensors, UII activation of G i coupled family members Gαi1, Gαi2, Gαi3, and Gαz was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. b The activation of the G q pathway was accessed using both a BRET biosensor and by determining the production levels of the second messenger IP 1 in the presence of 10 µM of the indicated biased ligand/antagonists. c Ca 2+ mobilization induced by graded concentrations (10 −11 to 10 −6 M) of UII on hUT-transfected HEK-293 cells pretreated with buffer or biased ligand/antagonists. d Using BRET biosensors, UII activation of G o coupled family members GoA and GoB was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists. e Using BRET biosensors, the UII-induced recruitment of β-arrestin 1 and β-arrestin 2 was assessed in HEK293 cells transiently expressing hUT in the presence of 10 µM of the indicated biased ligand/antagonists ( a – e , n = 3; values are expressed as the mean ± SEM). f Timeline of intracisternal injection of palosuran, GSK1562590 or urantide during SAH induction prior to CVS analysis and behavioral testing. g Graphs (right panel) representing changes in lumen area/wall thickness on MCA ( n = 6/condition). Values are expressed as the mean ± SEM. *** P < 0.001 for comparisons with aCSF + sham condition. $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Exploration in OFT (10 min) and sensorimotor functions in BWT ( n = 6–10/condition). Values are expressed as the mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001 for comparisons with aCSF + sham condition. $ P < 0.05; $$ P < 0.01; $$$ P < 0.001 for comparisons with aCSF + SAH condition (two-sided one-way analysis of variance (ANOVA), Bonferroni’s correction). Source data are provided as a Source Data file. f created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license ( https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en ).

Article Snippet: Finally, urantide (synthetized by Dr. Marc André Bonin, peptide synthesis platform, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec, Canada), GSK1562590 (Tocris, #5110) and palosuran (MedChemExpress, #HY-10655) were diluted in blood and intracisternally injected during SAH induction (10 -5 M, 60 µl at D-1, 30 µl at D0), and were also used for in vitro pharmacological experiments.

Techniques: Activation Assay, Expressing, Transfection, Injection