Journal: Emerging Infectious Diseases

Article Title: Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024

doi: 10.3201/eid3105.241123

Figure Lengend Snippet: Antiviral drug susceptibilities of influenza A(H1N1)pdm09 viruses, Japan, 2024*

Article Snippet: We assessed the susceptibility of the PA I38N mutant and representative pH1N1 viruses, including a PA I38T mutant virus isolated in Yamagata, to baloxavir acid (Funakoshi Co., Ltd., https://www.funakoshi.co.jp ) and 4 NA inhibitors approved in Japan: oseltamivir acid (active metabolite of oseltamivir), peramivir, zanamivir, and laninamivir (MedChemExpress, https://www.medchemexpress.com ).

Techniques: Virus

Journal: PLoS ONE

Article Title: Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice

doi: 10.1371/journal.pone.0230499

Figure Lengend Snippet: MRL/lpr female mice were treated with vehicle (Water) or oseltamivir phosphate (OP) at 12–13 weeks of age for 4 weeks. Untreated age-matched MRL/MpJ (MpJ) female mice served as non-nephritic lupus controls. Urine albumin was measured in 24 hr urine samples one day prior to beginning treatment (Pre-treatment) and one day prior to euthanasia (Endpoint). Both the absolute levels (A) and the change from Pre-treatment to Endpoint (B) in urine albumin are presented. (C) Renal pathology scores at the endpoint of the study. Means with standard deviations are presented. (D) Renal sections stained with H&E or PAS from the MRL/MpJ (MpJ) and MRL/lpr water-treated (lpr_Water) and OP-treated (lpr_OP) mice.

Article Snippet: Therefore, mice received vehicle (water) or 10 mg/kg/day oseltamivir phosphate (OP) (Santa Cruz Biotechnology sc-208135A; Dallas, TX) by gavage daily for four weeks.

Techniques: Staining

Journal: Emerging Infectious Diseases

Article Title: Antiviral Susceptibility of Influenza A(H5N1) Clade 2.3.2.1c and 2.3.4.4b Viruses from Humans, 2023–2024

doi: 10.3201/eid3104.241820

Figure Lengend Snippet: NA inhibitor susceptibility of highly pathogenic avian influenza A(H5N1) viruses isolated from humans in fluorescent NA inhibition assay, 2023–2024 *

Article Snippet: We dissolved the M2 blockers, amantadine hydrochloride (Sigma-Aldrich, https://www.sigmaaldrich.com ), rimantadine (Roche, https://www.roche.com ), and the NA inhibitors oseltamivir carboxylate, zanamivir, peramivir, and laninamivir (BioSynth, https://www.biosynth.com ) individually in sterile distilled water.

Techniques: Isolation, Inhibition, Virus, Control

Journal: International Journal of Molecular Sciences

Article Title: Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy

doi: 10.3390/ijms23073940

Figure Lengend Snippet: Cytotoxicity and antiviral activity of compounds against influenza virus infection.

Article Snippet: Oseltamivir phosphate, 3-methyladenine (3-MA), and Bafilomycin A1 (Baf A1) were from MCE (Shanghai, China).

Techniques: Activity Assay, Virus, Infection

Journal: Pathogens

Article Title: In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients

doi: 10.3390/pathogens9090725

Figure Lengend Snippet: Immunocompromised patients infected with the dual H275Y mutant influenza A(H1N1)pdm09 viruses.

Article Snippet: Oseltamivir acid, peramivir trihydrate, and zanamivir hydrate were purchased from Biosynth Carbosynth (Berkshire, UK).

Techniques: Infection, Mutagenesis

Journal: Pathogens

Article Title: In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients

doi: 10.3390/pathogens9090725

Figure Lengend Snippet: Antiviral susceptibilities of the dual H275Y mutant influenza A(H1N1)pdm09 viruses.

Article Snippet: Oseltamivir acid, peramivir trihydrate, and zanamivir hydrate were purchased from Biosynth Carbosynth (Berkshire, UK).

Techniques: Mutagenesis

Journal: Virologica Sinica

Article Title: The Establishment and Validation of the Human U937 Cell Line as a Cellular Model to Screen Immunomodulatory Agents Regulating Cytokine Release Induced by Influenza Virus Infection

doi: 10.1007/s12250-019-00145-w

Figure Lengend Snippet: Validation of U937 cell model with a panel of antiviral and immunomodulatory agents.

Article Snippet: Oseltamivir (GS 4071) was purchased from Toronto Research Chemicals (Toronto, Canada).

Techniques: In Vivo