ns6180 Search Results


ns6180  (Alomone Labs)
90
Alomone Labs ns6180
The antiviral effect of TRAM-34 is independent of its cellular target KCa3.1. (A) Structures of TRAM-34, clotrimazole, senicapoc, and <t>NS6180.</t> (B) Dose-response characteristics of candidate drugs against VSV pseudotypes displaying MACV GP or VSV G. Monolayers of A549 cells were pretreated with increasing drug concentrations for 30 min, followed by infection with the indicated pseudotypes and detection of infection as in Fig. 2B. (C) Apparent IC50 of the tested drugs against MACV pseudotypes calculated from panel B compared to the reported IC50 against the pharmacological drug target KCa3.1. Please note that the antiviral activity of drugs does not correlate with their published target-specific efficacy. (D) Deletion of KCa3.1 does not affect infection with MACV pseudotypes. Wild-type (WT) and KCa3.1 null HeLa cells were pretreated with TRAM-34 (20 μM) or solvent control (DMSO) and infected with the indicated VSV pseudotypes as in Fig. 2B. Infection was detected by direct fluorescence detection of the EGFP and the control (DMSO) set at 100%. The data are means + the SD (n = 3).
Ns6180, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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disulfiram b0240  (MedChemExpress)
91
MedChemExpress disulfiram b0240
The antiviral effect of TRAM-34 is independent of its cellular target KCa3.1. (A) Structures of TRAM-34, clotrimazole, senicapoc, and <t>NS6180.</t> (B) Dose-response characteristics of candidate drugs against VSV pseudotypes displaying MACV GP or VSV G. Monolayers of A549 cells were pretreated with increasing drug concentrations for 30 min, followed by infection with the indicated pseudotypes and detection of infection as in Fig. 2B. (C) Apparent IC50 of the tested drugs against MACV pseudotypes calculated from panel B compared to the reported IC50 against the pharmacological drug target KCa3.1. Please note that the antiviral activity of drugs does not correlate with their published target-specific efficacy. (D) Deletion of KCa3.1 does not affect infection with MACV pseudotypes. Wild-type (WT) and KCa3.1 null HeLa cells were pretreated with TRAM-34 (20 μM) or solvent control (DMSO) and infected with the indicated VSV pseudotypes as in Fig. 2B. Infection was detected by direct fluorescence detection of the EGFP and the control (DMSO) set at 100%. The data are means + the SD (n = 3).
Disulfiram B0240, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 91 stars, based on 1 article reviews
disulfiram b0240 - by Bioz Stars, 2026-03
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ns6180  (Wulff labs)
90
Wulff labs ns6180
The antiviral effect of TRAM-34 is independent of its cellular target KCa3.1. (A) Structures of TRAM-34, clotrimazole, senicapoc, and <t>NS6180.</t> (B) Dose-response characteristics of candidate drugs against VSV pseudotypes displaying MACV GP or VSV G. Monolayers of A549 cells were pretreated with increasing drug concentrations for 30 min, followed by infection with the indicated pseudotypes and detection of infection as in Fig. 2B. (C) Apparent IC50 of the tested drugs against MACV pseudotypes calculated from panel B compared to the reported IC50 against the pharmacological drug target KCa3.1. Please note that the antiviral activity of drugs does not correlate with their published target-specific efficacy. (D) Deletion of KCa3.1 does not affect infection with MACV pseudotypes. Wild-type (WT) and KCa3.1 null HeLa cells were pretreated with TRAM-34 (20 μM) or solvent control (DMSO) and infected with the indicated VSV pseudotypes as in Fig. 2B. Infection was detected by direct fluorescence detection of the EGFP and the control (DMSO) set at 100%. The data are means + the SD (n = 3).
Ns6180, supplied by Wulff labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ns6180/product/Wulff labs
Average 90 stars, based on 1 article reviews
ns6180 - by Bioz Stars, 2026-03
90/100 stars
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ns6180  (NeuroSearch A/S)
90
NeuroSearch A/S ns6180
The antiviral effect of TRAM-34 is independent of its cellular target KCa3.1. (A) Structures of TRAM-34, clotrimazole, senicapoc, and <t>NS6180.</t> (B) Dose-response characteristics of candidate drugs against VSV pseudotypes displaying MACV GP or VSV G. Monolayers of A549 cells were pretreated with increasing drug concentrations for 30 min, followed by infection with the indicated pseudotypes and detection of infection as in Fig. 2B. (C) Apparent IC50 of the tested drugs against MACV pseudotypes calculated from panel B compared to the reported IC50 against the pharmacological drug target KCa3.1. Please note that the antiviral activity of drugs does not correlate with their published target-specific efficacy. (D) Deletion of KCa3.1 does not affect infection with MACV pseudotypes. Wild-type (WT) and KCa3.1 null HeLa cells were pretreated with TRAM-34 (20 μM) or solvent control (DMSO) and infected with the indicated VSV pseudotypes as in Fig. 2B. Infection was detected by direct fluorescence detection of the EGFP and the control (DMSO) set at 100%. The data are means + the SD (n = 3).
Ns6180, supplied by NeuroSearch A/S, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ns6180/product/NeuroSearch A/S
Average 90 stars, based on 1 article reviews
ns6180 - by Bioz Stars, 2026-03
90/100 stars
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Image Search Results


The antiviral effect of TRAM-34 is independent of its cellular target KCa3.1. (A) Structures of TRAM-34, clotrimazole, senicapoc, and NS6180. (B) Dose-response characteristics of candidate drugs against VSV pseudotypes displaying MACV GP or VSV G. Monolayers of A549 cells were pretreated with increasing drug concentrations for 30 min, followed by infection with the indicated pseudotypes and detection of infection as in Fig. 2B. (C) Apparent IC50 of the tested drugs against MACV pseudotypes calculated from panel B compared to the reported IC50 against the pharmacological drug target KCa3.1. Please note that the antiviral activity of drugs does not correlate with their published target-specific efficacy. (D) Deletion of KCa3.1 does not affect infection with MACV pseudotypes. Wild-type (WT) and KCa3.1 null HeLa cells were pretreated with TRAM-34 (20 μM) or solvent control (DMSO) and infected with the indicated VSV pseudotypes as in Fig. 2B. Infection was detected by direct fluorescence detection of the EGFP and the control (DMSO) set at 100%. The data are means + the SD (n = 3).

Journal: Journal of Virology

Article Title: Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion

doi: 10.1128/JVI.01744-18

Figure Lengend Snippet: The antiviral effect of TRAM-34 is independent of its cellular target KCa3.1. (A) Structures of TRAM-34, clotrimazole, senicapoc, and NS6180. (B) Dose-response characteristics of candidate drugs against VSV pseudotypes displaying MACV GP or VSV G. Monolayers of A549 cells were pretreated with increasing drug concentrations for 30 min, followed by infection with the indicated pseudotypes and detection of infection as in Fig. 2B. (C) Apparent IC50 of the tested drugs against MACV pseudotypes calculated from panel B compared to the reported IC50 against the pharmacological drug target KCa3.1. Please note that the antiviral activity of drugs does not correlate with their published target-specific efficacy. (D) Deletion of KCa3.1 does not affect infection with MACV pseudotypes. Wild-type (WT) and KCa3.1 null HeLa cells were pretreated with TRAM-34 (20 μM) or solvent control (DMSO) and infected with the indicated VSV pseudotypes as in Fig. 2B. Infection was detected by direct fluorescence detection of the EGFP and the control (DMSO) set at 100%. The data are means + the SD (n = 3).

Article Snippet: Clotrimazole and senicapoc were obtained from MedChem Express, TRAM-34 was obtained from Sigma, and NS6180 was obtained from Alomone.

Techniques: Infection, Activity Assay, Fluorescence