ns1738 Search Results


ns1738  (Tocris)
94
Tocris ns1738
Figure1. NicotineenhancedtheamplitudeofmossyfiberEPSCswiththeadditionofan7 nAChR PAM. A, Representative traces of eEPSCs recorded from a CA3 pyramidal neuron before (left),during(middle),andafter(right)applicationofnicotine(10M)andthe7nAChRPAM <t>NS1738</t> (5 M). B, Normalized EPSC amplitude was plotted against the time of nicotine appli- cation (from 0 to 10 min) with (E) and without (F) NS1738 (5 M). C, Normalized EPSC amplitude was plotted against the time of nicotine and NS1738 application (from 0 to 10 min) with(Œ)andwithout(E)thepresenceofMLA(20nM),an7nAChR-selectiveantagonist.D, The histogram shows nicotine-induced net change of normalized EPSC amplitude in listed conditions.DatashownaremeanSEM;statisticalsignificancewasdeterminedbyStudent’s t test (*p 0.05).
Ns1738, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ns 1738  (Santa Cruz Biotechnology)
91
Santa Cruz Biotechnology ns 1738
Figure1. NicotineenhancedtheamplitudeofmossyfiberEPSCswiththeadditionofan7 nAChR PAM. A, Representative traces of eEPSCs recorded from a CA3 pyramidal neuron before (left),during(middle),andafter(right)applicationofnicotine(10M)andthe7nAChRPAM <t>NS1738</t> (5 M). B, Normalized EPSC amplitude was plotted against the time of nicotine appli- cation (from 0 to 10 min) with (E) and without (F) NS1738 (5 M). C, Normalized EPSC amplitude was plotted against the time of nicotine and NS1738 application (from 0 to 10 min) with(Œ)andwithout(E)thepresenceofMLA(20nM),an7nAChR-selectiveantagonist.D, The histogram shows nicotine-induced net change of normalized EPSC amplitude in listed conditions.DatashownaremeanSEM;statisticalsignificancewasdeterminedbyStudent’s t test (*p 0.05).
Ns 1738, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ns 1738  (Tocris)
93
Tocris ns 1738
Figure1. NicotineenhancedtheamplitudeofmossyfiberEPSCswiththeadditionofan7 nAChR PAM. A, Representative traces of eEPSCs recorded from a CA3 pyramidal neuron before (left),during(middle),andafter(right)applicationofnicotine(10M)andthe7nAChRPAM <t>NS1738</t> (5 M). B, Normalized EPSC amplitude was plotted against the time of nicotine appli- cation (from 0 to 10 min) with (E) and without (F) NS1738 (5 M). C, Normalized EPSC amplitude was plotted against the time of nicotine and NS1738 application (from 0 to 10 min) with(Œ)andwithout(E)thepresenceofMLA(20nM),an7nAChR-selectiveantagonist.D, The histogram shows nicotine-induced net change of normalized EPSC amplitude in listed conditions.DatashownaremeanSEM;statisticalsignificancewasdeterminedbyStudent’s t test (*p 0.05).
Ns 1738, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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ns1738  (Cayman Chemical)
90
Cayman Chemical ns1738
Figure1. NicotineenhancedtheamplitudeofmossyfiberEPSCswiththeadditionofan7 nAChR PAM. A, Representative traces of eEPSCs recorded from a CA3 pyramidal neuron before (left),during(middle),andafter(right)applicationofnicotine(10M)andthe7nAChRPAM <t>NS1738</t> (5 M). B, Normalized EPSC amplitude was plotted against the time of nicotine appli- cation (from 0 to 10 min) with (E) and without (F) NS1738 (5 M). C, Normalized EPSC amplitude was plotted against the time of nicotine and NS1738 application (from 0 to 10 min) with(Œ)andwithout(E)thepresenceofMLA(20nM),an7nAChR-selectiveantagonist.D, The histogram shows nicotine-induced net change of normalized EPSC amplitude in listed conditions.DatashownaremeanSEM;statisticalsignificancewasdeterminedbyStudent’s t test (*p 0.05).
Ns1738, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ns1738 (1-(5-chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea  (NeuroSearch A/S)
90
NeuroSearch A/S ns1738 (1-(5-chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea
Figure1. NicotineenhancedtheamplitudeofmossyfiberEPSCswiththeadditionofan7 nAChR PAM. A, Representative traces of eEPSCs recorded from a CA3 pyramidal neuron before (left),during(middle),andafter(right)applicationofnicotine(10M)andthe7nAChRPAM <t>NS1738</t> (5 M). B, Normalized EPSC amplitude was plotted against the time of nicotine appli- cation (from 0 to 10 min) with (E) and without (F) NS1738 (5 M). C, Normalized EPSC amplitude was plotted against the time of nicotine and NS1738 application (from 0 to 10 min) with(Œ)andwithout(E)thepresenceofMLA(20nM),an7nAChR-selectiveantagonist.D, The histogram shows nicotine-induced net change of normalized EPSC amplitude in listed conditions.DatashownaremeanSEM;statisticalsignificancewasdeterminedbyStudent’s t test (*p 0.05).
Ns1738 (1 (5 Chloro 2 Hydroxy Phenyl) 3 (2 Chloro 5 Trifluoromethyl Phenyl) Urea, supplied by NeuroSearch A/S, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ns1738 (1-(5-chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea/product/NeuroSearch A/S
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ns-1738  (Adooq Bioscience LLC)
90
Adooq Bioscience LLC ns-1738
Figure1. NicotineenhancedtheamplitudeofmossyfiberEPSCswiththeadditionofan7 nAChR PAM. A, Representative traces of eEPSCs recorded from a CA3 pyramidal neuron before (left),during(middle),andafter(right)applicationofnicotine(10M)andthe7nAChRPAM <t>NS1738</t> (5 M). B, Normalized EPSC amplitude was plotted against the time of nicotine appli- cation (from 0 to 10 min) with (E) and without (F) NS1738 (5 M). C, Normalized EPSC amplitude was plotted against the time of nicotine and NS1738 application (from 0 to 10 min) with(Œ)andwithout(E)thepresenceofMLA(20nM),an7nAChR-selectiveantagonist.D, The histogram shows nicotine-induced net change of normalized EPSC amplitude in listed conditions.DatashownaremeanSEM;statisticalsignificancewasdeterminedbyStudent’s t test (*p 0.05).
Ns 1738, supplied by Adooq Bioscience LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ns1738  (Kuang Lung Shing)
90
Kuang Lung Shing ns1738
Positive allosteric modulators of neuronal nAChRs and studies investigating them as pharmacotherapies for tobacco use disorder
Ns1738, supplied by Kuang Lung Shing, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ns-1738  (Abbott Laboratories)
90
Abbott Laboratories ns-1738
Positive allosteric modulators of neuronal nAChRs and studies investigating them as pharmacotherapies for tobacco use disorder
Ns 1738, supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ns1738  (Johnson & Johnson)
90
Johnson & Johnson ns1738
Positive allosteric modulators of neuronal nAChRs and studies investigating them as pharmacotherapies for tobacco use disorder
Ns1738, supplied by Johnson & Johnson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Figure1. NicotineenhancedtheamplitudeofmossyfiberEPSCswiththeadditionofan7 nAChR PAM. A, Representative traces of eEPSCs recorded from a CA3 pyramidal neuron before (left),during(middle),andafter(right)applicationofnicotine(10M)andthe7nAChRPAM NS1738 (5 M). B, Normalized EPSC amplitude was plotted against the time of nicotine appli- cation (from 0 to 10 min) with (E) and without (F) NS1738 (5 M). C, Normalized EPSC amplitude was plotted against the time of nicotine and NS1738 application (from 0 to 10 min) with(Œ)andwithout(E)thepresenceofMLA(20nM),an7nAChR-selectiveantagonist.D, The histogram shows nicotine-induced net change of normalized EPSC amplitude in listed conditions.DatashownaremeanSEM;statisticalsignificancewasdeterminedbyStudent’s t test (*p 0.05).

Journal: Journal of Neuroscience

Article Title: Presynaptic 7 Nicotinic Acetylcholine Receptors Enhance Hippocampal Mossy Fiber Glutamatergic Transmission via PKA Activation

doi: 10.1523/jneurosci.2973-13.2014

Figure Lengend Snippet: Figure1. NicotineenhancedtheamplitudeofmossyfiberEPSCswiththeadditionofan7 nAChR PAM. A, Representative traces of eEPSCs recorded from a CA3 pyramidal neuron before (left),during(middle),andafter(right)applicationofnicotine(10M)andthe7nAChRPAM NS1738 (5 M). B, Normalized EPSC amplitude was plotted against the time of nicotine appli- cation (from 0 to 10 min) with (E) and without (F) NS1738 (5 M). C, Normalized EPSC amplitude was plotted against the time of nicotine and NS1738 application (from 0 to 10 min) with(Œ)andwithout(E)thepresenceofMLA(20nM),an7nAChR-selectiveantagonist.D, The histogram shows nicotine-induced net change of normalized EPSC amplitude in listed conditions.DatashownaremeanSEM;statisticalsignificancewasdeterminedbyStudent’s t test (*p 0.05).

Article Snippet: QX314, CNQX, DCG-IV, NS1738, KT5720, PKI 14 –22 amide peptide, KN62, PNU-282987, and PNU-120596 were purchased from Tocris Bioscience.

Techniques:

Figure 3. Presynaptic nAChRs mediated nicotine’s action on mossy fiber EPSC amplitude. A, Representative traces of paired EPSCs evoked with 50 ms interval were shown before and during application of nicotine and the 7 nAChR PAM NS1738. B, PPRs of EPSCs were plotted for each individual experiment. Summary of data showed a significant reduction in PPR for wild-type mice (C), but not 7 nAChR knock-out mice (D) after 10 min application of nicotine and the 7 nAChR PAM. E, Normalized EPSC amplitude was plotted against the application time of nicotine and 7 nAChR PAM (from 0 to 10 min)withstandard(E)andBAPTA(10mM)-containinginternalsolution().F,Thehistogramindicatesthatthenicotine and the 7 nAChR PAM-induced net change of normalized EPSC amplitude remains the same after postsynaptic dialysis of BAPTA (10 mM). Data shown are mean SEM; statistical significance was determined by Student’s t test (*p 0.05; NS, p 0.05).

Journal: Journal of Neuroscience

Article Title: Presynaptic 7 Nicotinic Acetylcholine Receptors Enhance Hippocampal Mossy Fiber Glutamatergic Transmission via PKA Activation

doi: 10.1523/jneurosci.2973-13.2014

Figure Lengend Snippet: Figure 3. Presynaptic nAChRs mediated nicotine’s action on mossy fiber EPSC amplitude. A, Representative traces of paired EPSCs evoked with 50 ms interval were shown before and during application of nicotine and the 7 nAChR PAM NS1738. B, PPRs of EPSCs were plotted for each individual experiment. Summary of data showed a significant reduction in PPR for wild-type mice (C), but not 7 nAChR knock-out mice (D) after 10 min application of nicotine and the 7 nAChR PAM. E, Normalized EPSC amplitude was plotted against the application time of nicotine and 7 nAChR PAM (from 0 to 10 min)withstandard(E)andBAPTA(10mM)-containinginternalsolution().F,Thehistogramindicatesthatthenicotine and the 7 nAChR PAM-induced net change of normalized EPSC amplitude remains the same after postsynaptic dialysis of BAPTA (10 mM). Data shown are mean SEM; statistical significance was determined by Student’s t test (*p 0.05; NS, p 0.05).

Article Snippet: QX314, CNQX, DCG-IV, NS1738, KT5720, PKI 14 –22 amide peptide, KN62, PNU-282987, and PNU-120596 were purchased from Tocris Bioscience.

Techniques: Knock-Out

Positive allosteric modulators of neuronal nAChRs and studies investigating them as pharmacotherapies for tobacco use disorder

Journal: Pharmacological Reviews

Article Title: More than Smoke and Patches: The Quest for Pharmacotherapies to Treat Tobacco Use Disorder

doi: 10.1124/pr.119.018028

Figure Lengend Snippet: Positive allosteric modulators of neuronal nAChRs and studies investigating them as pharmacotherapies for tobacco use disorder

Article Snippet: In this study, it was found that NS1738 has three theoretical binding sites ( Kuang et al., 2016 ).

Techniques: Activity Assay, In Vivo