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Partek normalized ncrna microarray data
(A) Unsupervised hierarchical clustering analysis of 100 significantly differentially expressed ncRNAs between all hemophilia A patients (yellow and orange bars) and controls (red bar) shows the distinct <t>ncRNA</t> expression pattern of the two group (p-value < 0.01). Each row represents a subject, whereas each column is a ncRNA probe. Blue color in the heat map indicates down-regulation, whereas red indicates up-regulation. (B) Principal component analysis of samples on the basis of the 100 significantly differentially expressed ncRNAs identified by the ANOVA analysis described above. Yellow spheres represent HA samples, whereas turquoise spheres represent unaffected controls.
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(A) Unsupervised hierarchical clustering analysis of 100 significantly differentially expressed ncRNAs between all hemophilia A patients (yellow and orange bars) and controls (red bar) shows the distinct ncRNA expression pattern of the two group (p-value < 0.01). Each row represents a subject, whereas each column is a ncRNA probe. Blue color in the heat map indicates down-regulation, whereas red indicates up-regulation. (B) Principal component analysis of samples on the basis of the 100 significantly differentially expressed ncRNAs identified by the ANOVA analysis described above. Yellow spheres represent HA samples, whereas turquoise spheres represent unaffected controls.

Journal: PLoS ONE

Article Title: Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene

doi: 10.1371/journal.pone.0132433

Figure Lengend Snippet: (A) Unsupervised hierarchical clustering analysis of 100 significantly differentially expressed ncRNAs between all hemophilia A patients (yellow and orange bars) and controls (red bar) shows the distinct ncRNA expression pattern of the two group (p-value < 0.01). Each row represents a subject, whereas each column is a ncRNA probe. Blue color in the heat map indicates down-regulation, whereas red indicates up-regulation. (B) Principal component analysis of samples on the basis of the 100 significantly differentially expressed ncRNAs identified by the ANOVA analysis described above. Yellow spheres represent HA samples, whereas turquoise spheres represent unaffected controls.

Article Snippet: To increase the stringency of statistical significance analysis, the normalized ncRNA microarray data from Partek Genomics Suite software were also uploaded into the TMeV software and SAM analysis was conducted.

Techniques: Expressing

(A) 3-class ANOVA analysis. Principal component analysis of samples based on 88 significantly differentially expressed ncRNAs from 3-class ANOVA analysis (p-value < 0.01) reduces the dimentionality of the data and shows the clear separation between the hemophilia A patients with inhibitor development (red), the hemophilia A patients without inhibitor development (yellow), and the controls (turquoise). (B) 3-class SAM analysis. Principal component analysis of samples based on 11 significantly differentially expressed ncRNA probes from 3-class SAM analysis (FDR < 5%) reveals the distinct separation between the hemophilia A patients with inhibitor development (red), the hemophilia A patients without inhibitor development (yellow), and the controls (turquoise).

Journal: PLoS ONE

Article Title: Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene

doi: 10.1371/journal.pone.0132433

Figure Lengend Snippet: (A) 3-class ANOVA analysis. Principal component analysis of samples based on 88 significantly differentially expressed ncRNAs from 3-class ANOVA analysis (p-value < 0.01) reduces the dimentionality of the data and shows the clear separation between the hemophilia A patients with inhibitor development (red), the hemophilia A patients without inhibitor development (yellow), and the controls (turquoise). (B) 3-class SAM analysis. Principal component analysis of samples based on 11 significantly differentially expressed ncRNA probes from 3-class SAM analysis (FDR < 5%) reveals the distinct separation between the hemophilia A patients with inhibitor development (red), the hemophilia A patients without inhibitor development (yellow), and the controls (turquoise).

Article Snippet: To increase the stringency of statistical significance analysis, the normalized ncRNA microarray data from Partek Genomics Suite software were also uploaded into the TMeV software and SAM analysis was conducted.

Techniques:

Significantly differentially regulated ncRNAs identified by SAM analysis. A 3-class SAM analysis of ncRNA microarray data revealed 11 ncRNA probes that were differentially expressed between hemophilia A (HA) patients with inhibitor development (HAI), hemophilia A patients without inhibitor development (HAWI), and controls (C) with the false discovery rate less than 5%.

Journal: PLoS ONE

Article Title: Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene

doi: 10.1371/journal.pone.0132433

Figure Lengend Snippet: Significantly differentially regulated ncRNAs identified by SAM analysis. A 3-class SAM analysis of ncRNA microarray data revealed 11 ncRNA probes that were differentially expressed between hemophilia A (HA) patients with inhibitor development (HAI), hemophilia A patients without inhibitor development (HAWI), and controls (C) with the false discovery rate less than 5%.

Article Snippet: To increase the stringency of statistical significance analysis, the normalized ncRNA microarray data from Partek Genomics Suite software were also uploaded into the TMeV software and SAM analysis was conducted.

Techniques: Microarray

(A) Significant ncRNA probes were identified using 3-class ANOVA analysis with p-value < 0.01 and 3-class SAM analysis with FDR < 5%. A total of 4 ncRNAs (hsa-miR-1246, hsa-miR-4521, HBII-13, and SNORD121B) were found to overlap between the two statistical analyses. (B) Hsa-miR-1246 (red dot) is significantly down-regulated in HA patients with inhibitor relative to patients without inhibitor.

Journal: PLoS ONE

Article Title: Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene

doi: 10.1371/journal.pone.0132433

Figure Lengend Snippet: (A) Significant ncRNA probes were identified using 3-class ANOVA analysis with p-value < 0.01 and 3-class SAM analysis with FDR < 5%. A total of 4 ncRNAs (hsa-miR-1246, hsa-miR-4521, HBII-13, and SNORD121B) were found to overlap between the two statistical analyses. (B) Hsa-miR-1246 (red dot) is significantly down-regulated in HA patients with inhibitor relative to patients without inhibitor.

Article Snippet: To increase the stringency of statistical significance analysis, the normalized ncRNA microarray data from Partek Genomics Suite software were also uploaded into the TMeV software and SAM analysis was conducted.

Techniques:

Results of TaqMan ncRNA qRT-PCR analysis of differentially regulated ncRNAs. All cases (n = 9) and controls (n = 5) that were used for ncRNA microarray analysis were included in TaqMan ncRNA qRT-PCR analysis.

Journal: PLoS ONE

Article Title: Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene

doi: 10.1371/journal.pone.0132433

Figure Lengend Snippet: Results of TaqMan ncRNA qRT-PCR analysis of differentially regulated ncRNAs. All cases (n = 9) and controls (n = 5) that were used for ncRNA microarray analysis were included in TaqMan ncRNA qRT-PCR analysis.

Article Snippet: To increase the stringency of statistical significance analysis, the normalized ncRNA microarray data from Partek Genomics Suite software were also uploaded into the TMeV software and SAM analysis was conducted.

Techniques: Microarray