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Image Search Results
Journal: Journal of Neurology
Article Title: Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy
doi: 10.1007/s00415-022-11035-9
Figure Lengend Snippet: Study of skin innervation with PGP 9.5 and GAP-43. Mean intra-epidermal nerve fiber density (IENFD) at distal leg in healthy subjects, before-oxaliplatin and 3 months after last oxaliplatin cycle. Statistically significant differences between healthy subjects and before-oxaliplatin are indicated for PGP 9.5 (*) and GAP-43 (**). The PGP 9.5/GAP-43 ratio (%) is included also for comparison in the same graph
Article Snippet: Three non-consecutive sections were incubated for 24 h at room temperature with the primary
Techniques:
Journal: Journal of Neurology
Article Title: Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy
doi: 10.1007/s00415-022-11035-9
Figure Lengend Snippet: Examples of double immunofluorescence labeling images with confocal microscope. A , B Double-staining with PGP 9.5 (red) and GAP-43 (green) from one patient before ( A ) and after ( B ) receiving oxaliplatin. In image A , it is possible to identify co-localization between both PGP 9.5 and GAP-43 (inset) as well as no-coincident nerve fibers (GAP-43 +); Despite generalized axonal loss in image B , it is possible to find PGP 9.5 and GAP-43 + remaining dermal fibers; Image shows generalized fragmentations of dermal fibers. C , D Double-staining of PGP 9.5 and OXPHOS (keratinocytes) with DAPI (nucleus) in a skin biopsy from 4th lateral aspect of finger at hand (glabrous skin) showing a Meissner corpuscle before ( C) and after ( D ) receiving oxaliplatin. Scale bar of 50 µm is placed as reference in right images
Article Snippet: Three non-consecutive sections were incubated for 24 h at room temperature with the primary
Techniques: Immunofluorescence, Labeling, Microscopy, Double Staining