navigation Search Results


human nav1 1  (OriGene)
90
OriGene human nav1 1
Human Nav1 1, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/Neuron+navigator+1+(NAV1)+(NM_020443)+Human+Tagged+ORF+Clone/pm28607094-167-0-5
Average 90 stars, based on 1 article reviews
human nav1 1 - by Bioz Stars, 2026-09
90/100 stars
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navigation toolbox  (MathWorks Inc)
93
MathWorks Inc navigation toolbox
Navigation Toolbox, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/Navigation+Toolbox/pm37999190-170-2-1
Average 93 stars, based on 1 article reviews
navigation toolbox - by Bioz Stars, 2026-09
93/100 stars
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anti nav1  (Santa Cruz Biotechnology)
91
Santa Cruz Biotechnology anti nav1
Anti Nav1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/Neuron+navigator+1+Antibody/pmc07480110-263-5-7
Average 91 stars, based on 1 article reviews
anti nav1 - by Bioz Stars, 2026-09
91/100 stars
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antibodies against mouse nav1  (Proteintech)
94
Proteintech antibodies against mouse nav1
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Antibodies Against Mouse Nav1, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/neuron+navigator+1+Antibody/10__1096_slash_fj__202402876r-68-7-11
Average 94 stars, based on 1 article reviews
antibodies against mouse nav1 - by Bioz Stars, 2026-09
94/100 stars
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antibodies against nav1 5  (Boster Bio)
94
Boster Bio antibodies against nav1 5
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Antibodies Against Nav1 5, supplied by Boster Bio, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/Anti-Neuron+Navigator+1+NAV1+Antibody/10__3390_slash_biomedicines14030582-120-7-21
Average 94 stars, based on 1 article reviews
antibodies against nav1 5 - by Bioz Stars, 2026-09
94/100 stars
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scales ohaus tm navigator tm portable balance model nv222  (OHAUS Corporation)
96
OHAUS Corporation scales ohaus tm navigator tm portable balance model nv222
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Scales Ohaus Tm Navigator Tm Portable Balance Model Nv222, supplied by OHAUS Corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/Weight/med_rxiv__2024__06__26__24308549-57-40-41
Average 96 stars, based on 1 article reviews
scales ohaus tm navigator tm portable balance model nv222 - by Bioz Stars, 2026-09
96/100 stars
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freestyle navigator abbott ✓  (Abbott Laboratories)
86
Abbott Laboratories freestyle navigator abbott ✓
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Freestyle Navigator Abbott ✓, supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/freestyle+navigator/10__1002_slash_aisy__202400822-80-34-36
Average 86 stars, based on 1 article reviews
freestyle navigator abbott ✓ - by Bioz Stars, 2026-09
86/100 stars
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real-time kinematic gps system trimble rtk 5700 with zephyr geodetic antenna  (Trimble Navigation)
90
Trimble Navigation real-time kinematic gps system trimble rtk 5700 with zephyr geodetic antenna
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Real Time Kinematic Gps System Trimble Rtk 5700 With Zephyr Geodetic Antenna, supplied by Trimble Navigation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/real+time+kinematic+gps+system+trimble+rtk+5700+with+zephyr+geodetic+antenna/pmc03231425-102-14-25
Average 90 stars, based on 1 article reviews
real-time kinematic gps system trimble rtk 5700 with zephyr geodetic antenna - by Bioz Stars, 2026-09
90/100 stars
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chemotactic navigation  (Florman Family Foundation)
90
Florman Family Foundation chemotactic navigation
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Chemotactic Navigation, supplied by Florman Family Foundation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/chemotactic+navigation/pmc03136206-99-7-21
Average 90 stars, based on 1 article reviews
chemotactic navigation - by Bioz Stars, 2026-09
90/100 stars
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geomanager™ solution  (Trimble Navigation)
90
Trimble Navigation geomanager™ solution
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Geomanager™ Solution, supplied by Trimble Navigation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/geomanager++solution/us08344879-236-36-41
Average 90 stars, based on 1 article reviews
geomanager™ solution - by Bioz Stars, 2026-09
90/100 stars
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portable device 215  (Trimble Navigation)
90
Trimble Navigation portable device 215
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Portable Device 215, supplied by Trimble Navigation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/portable+device+215/us08560237-145-13-33
Average 90 stars, based on 1 article reviews
portable device 215 - by Bioz Stars, 2026-09
90/100 stars
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embedded pc-104 trimble navigation gps  (Trimble Navigation)
90
Trimble Navigation embedded pc-104 trimble navigation gps
FIGURE 4 | EGF-induced macropinocytosis is partially dependent on <t>NAV1.</t> (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.
Embedded Pc 104 Trimble Navigation Gps, supplied by Trimble Navigation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/navigation/embedded+pc+104+trimble+navigation+gps/us07812711-170-7-8
Average 90 stars, based on 1 article reviews
embedded pc-104 trimble navigation gps - by Bioz Stars, 2026-09
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Image Search Results


FIGURE 4 | EGF-induced macropinocytosis is partially dependent on NAV1. (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.

Journal: The FASEB Journal

Article Title: EGF‐Induced Macropinocytosis Promotes NAV1‐Dependent Internalization of Occludin in Keratinocytes

doi: 10.1096/fj.202402876r

Figure Lengend Snippet: FIGURE 4 | EGF-induced macropinocytosis is partially dependent on NAV1. (A) Gene expression levels of NAV1 in HaCaT cells at 6- and 24-h post-stimulation by EGF (10 ng/mL). Data are presented as mean ± SD. Student's t-test was conducted for comparison. *p < 0.05. (B) HaCaT cells were transfected with siRNA for NAV1 (si NAV1-1 and si NAV1-2) or negative control siRNA (si NC). The efficiency of siRNA-mediated gene knockdown was confirmed by RT-qPCR. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was con- ducted for comparison. ***p < 0.001. (C) HaCat cells transfected with siNAV1-1, siNAV1-2, or siNC were differentiated by 2.8 mM calcium chloride solution followed by EGF stimulation (10 ng/mL). Six hours after EGF application, 70 kDa FITC-dextran uptake was assessed using flow cytometry. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for MFI analysis. ****p < 0.0001. (D) Representative flow cytometry histogram plots depicting internalization of 70 kDa FITC-dextran by HaCaT cells transfected with siNAV1-1, siNAV1-2, and siNC, followed by EGF stimulation.

Article Snippet: After blocking, sections were incubated with primary antibodies against mouse NAV1 (Proteintech) or human NAV1 (Atlas Antibodies, Stockholm, Sweden) overnight at 4°C.

Techniques: Gene Expression, Comparison, Transfection, Negative Control, Knockdown, Quantitative RT-PCR, Flow Cytometry

FIGURE 6 | NAV1 expression and localization in the skin of the MC903-induced AD-like skin dermatitis model and AD patient samples. (A, B) Gene expression levels of Nav1 (A) and Egf (B) in the epidermis of the ear of MC903-treated mice (N = 6–8) were compared with those of the mock- treated control group (N = 7–8). A total of six to eight ears from three to four mice in each group were used in this experiment, with evaluations compiled from two independent experiments. Data are presented as mean ± SD. An unpaired t-test with Welch's correction was conducted for com- parison. *p < 0.05. (C) Immunohistochemical staining of NAV1 in the skin of mice treated with mock or MC903 at Day 10. Scale bar is 100 μm. (D) Immunohistochemical staining of NAV1 in the skin sections from healthy controls and patients with AD. Results are representative of 4 healthy con- trols and 4 AD patients. The scale bar represents 200 μm. (E) The percentage of areas with NAV1 staining in the epidermis and dermis of the lesional skin of AD and the skin of healthy counterparts. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for comparison. ****p < 0.0001. ns, not significant.

Journal: The FASEB Journal

Article Title: EGF‐Induced Macropinocytosis Promotes NAV1‐Dependent Internalization of Occludin in Keratinocytes

doi: 10.1096/fj.202402876r

Figure Lengend Snippet: FIGURE 6 | NAV1 expression and localization in the skin of the MC903-induced AD-like skin dermatitis model and AD patient samples. (A, B) Gene expression levels of Nav1 (A) and Egf (B) in the epidermis of the ear of MC903-treated mice (N = 6–8) were compared with those of the mock- treated control group (N = 7–8). A total of six to eight ears from three to four mice in each group were used in this experiment, with evaluations compiled from two independent experiments. Data are presented as mean ± SD. An unpaired t-test with Welch's correction was conducted for com- parison. *p < 0.05. (C) Immunohistochemical staining of NAV1 in the skin of mice treated with mock or MC903 at Day 10. Scale bar is 100 μm. (D) Immunohistochemical staining of NAV1 in the skin sections from healthy controls and patients with AD. Results are representative of 4 healthy con- trols and 4 AD patients. The scale bar represents 200 μm. (E) The percentage of areas with NAV1 staining in the epidermis and dermis of the lesional skin of AD and the skin of healthy counterparts. Data are presented as mean ± SD. One-way ANOVA analysis of variance with Dunnett's multiple comparisons was conducted for comparison. ****p < 0.0001. ns, not significant.

Article Snippet: After blocking, sections were incubated with primary antibodies against mouse NAV1 (Proteintech) or human NAV1 (Atlas Antibodies, Stockholm, Sweden) overnight at 4°C.

Techniques: Expressing, Gene Expression, Control, Immunohistochemical staining, Staining, Comparison

FIGURE 7 | Proposed model of EGF-induced macropinocytosis in keratinocytes. Under homeostatic conditions, keratinocytes maintain a stable barrier function with minimal macropinocytosis. Upon EGF stimulation, NAV1 and members of the Rho family are induced, leading to enhanced macropinocytosis. This process involves internalization of a tight junction protein, occludin, which may disrupt the epidermal barrier.

Journal: The FASEB Journal

Article Title: EGF‐Induced Macropinocytosis Promotes NAV1‐Dependent Internalization of Occludin in Keratinocytes

doi: 10.1096/fj.202402876r

Figure Lengend Snippet: FIGURE 7 | Proposed model of EGF-induced macropinocytosis in keratinocytes. Under homeostatic conditions, keratinocytes maintain a stable barrier function with minimal macropinocytosis. Upon EGF stimulation, NAV1 and members of the Rho family are induced, leading to enhanced macropinocytosis. This process involves internalization of a tight junction protein, occludin, which may disrupt the epidermal barrier.

Article Snippet: After blocking, sections were incubated with primary antibodies against mouse NAV1 (Proteintech) or human NAV1 (Atlas Antibodies, Stockholm, Sweden) overnight at 4°C.

Techniques: