mycn Search Results


mouse nqo1 complementary dna cdna  (Sino Biological)
91
Sino Biological mouse nqo1 complementary dna cdna
Mouse Nqo1 Complementary Dna Cdna, supplied by Sino Biological, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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n myc  (Santa Cruz Biotechnology)
96
Santa Cruz Biotechnology n myc
N Myc, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mycn antibody  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc mycn antibody
Mycn Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti n myc  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc anti n myc
Anti N Myc, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c myc  (Cell Signaling Technology Inc)
97
Cell Signaling Technology Inc c myc
C Myc, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mycn  (Proteintech)
93
Proteintech mycn
Fig. 2 <t>|</t> <t>Runx1t1</t> loss reverses <t>MYCN-mediated</t> sustained hyperplasia and induces ganglia neurite extension. a The percentage neuroblast hyperplasia scored from homozygous Th-MYCN (+/+) mice or littermate mice lacking the MYCN transgene (−/−), with either wild-type (+/+) or heterozygous loss (+/−) of Runx1t1. Scoring of N = 3–8 independent mice was performed for each genotype and timepoint. All data points were N = 3, except for +/+, +/+ week 1 and week 2 (N = 4); +/+, +/−day 0 (N = 8) and week 4 (N = 4); −/−, +/−day 0 (N = 6), week 1 (N = 4) and week 4 (N = 5). The graph is mean ± SEM. b Representative histology of RUNX1T1 staining in ganglia from mice homozygous for the Th-MYCN transgene, and either wild-type or heterozygous for Runx1t1 from day 0 and 4 weeks of age.
Mycn, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti n myc rabbit polyclonal antibodies  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc anti n myc rabbit polyclonal antibodies
Fig. 2 <t>|</t> <t>Runx1t1</t> loss reverses <t>MYCN-mediated</t> sustained hyperplasia and induces ganglia neurite extension. a The percentage neuroblast hyperplasia scored from homozygous Th-MYCN (+/+) mice or littermate mice lacking the MYCN transgene (−/−), with either wild-type (+/+) or heterozygous loss (+/−) of Runx1t1. Scoring of N = 3–8 independent mice was performed for each genotype and timepoint. All data points were N = 3, except for +/+, +/+ week 1 and week 2 (N = 4); +/+, +/−day 0 (N = 8) and week 4 (N = 4); −/−, +/−day 0 (N = 6), week 1 (N = 4) and week 4 (N = 5). The graph is mean ± SEM. b Representative histology of RUNX1T1 staining in ganglia from mice homozygous for the Th-MYCN transgene, and either wild-type or heterozygous for Runx1t1 from day 0 and 4 weeks of age.
Anti N Myc Rabbit Polyclonal Antibodies, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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otoferlin amino acids 1  (Addgene inc)
86
Addgene inc otoferlin amino acids 1
Multiple C2 domains mediate otoferlin–Loop1.3 interaction. (A–D) Binding curves for immobilized YFP-otoferlin C2A (A), C2B (B), C2D (C), and C2F (D) domains titrated against Loop1.3 at 0.1–50 µM free calcium. Data are fit with a Langmuir isotherm (solid lines). Insets depict 0–10 µM for clarity. Each experimental data point represents the mean value of n = 3. (E and F) Binding curves for immobilized YFP-otoferlin C2C and C2E domains titrated against Loop1.3. Colocalization between Loop1.3 and YFP-otoferlin (otoferlin amino acids 1–1,885) is included for comparison.
Otoferlin Amino Acids 1, supplied by Addgene inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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resource source identifier antibodies targ1  (Proteintech)
95
Proteintech resource source identifier antibodies targ1
Multiple C2 domains mediate otoferlin–Loop1.3 interaction. (A–D) Binding curves for immobilized YFP-otoferlin C2A (A), C2B (B), C2D (C), and C2F (D) domains titrated against Loop1.3 at 0.1–50 µM free calcium. Data are fit with a Langmuir isotherm (solid lines). Insets depict 0–10 µM for clarity. Each experimental data point represents the mean value of n = 3. (E and F) Binding curves for immobilized YFP-otoferlin C2C and C2E domains titrated against Loop1.3. Colocalization between Loop1.3 and YFP-otoferlin (otoferlin amino acids 1–1,885) is included for comparison.
Resource Source Identifier Antibodies Targ1, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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n terminal myc tag  (Sino Biological)
92
Sino Biological n terminal myc tag
Multiple C2 domains mediate otoferlin–Loop1.3 interaction. (A–D) Binding curves for immobilized YFP-otoferlin C2A (A), C2B (B), C2D (C), and C2F (D) domains titrated against Loop1.3 at 0.1–50 µM free calcium. Data are fit with a Langmuir isotherm (solid lines). Insets depict 0–10 µM for clarity. Each experimental data point represents the mean value of n = 3. (E and F) Binding curves for immobilized YFP-otoferlin C2C and C2E domains titrated against Loop1.3. Colocalization between Loop1.3 and YFP-otoferlin (otoferlin amino acids 1–1,885) is included for comparison.
N Terminal Myc Tag, supplied by Sino Biological, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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n myc parp1  (Sino Biological)
94
Sino Biological n myc parp1
Multiple C2 domains mediate otoferlin–Loop1.3 interaction. (A–D) Binding curves for immobilized YFP-otoferlin C2A (A), C2B (B), C2D (C), and C2F (D) domains titrated against Loop1.3 at 0.1–50 µM free calcium. Data are fit with a Langmuir isotherm (solid lines). Insets depict 0–10 µM for clarity. Each experimental data point represents the mean value of n = 3. (E and F) Binding curves for immobilized YFP-otoferlin C2C and C2E domains titrated against Loop1.3. Colocalization between Loop1.3 and YFP-otoferlin (otoferlin amino acids 1–1,885) is included for comparison.
N Myc Parp1, supplied by Sino Biological, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Fig. 2 | Runx1t1 loss reverses MYCN-mediated sustained hyperplasia and induces ganglia neurite extension. a The percentage neuroblast hyperplasia scored from homozygous Th-MYCN (+/+) mice or littermate mice lacking the MYCN transgene (−/−), with either wild-type (+/+) or heterozygous loss (+/−) of Runx1t1. Scoring of N = 3–8 independent mice was performed for each genotype and timepoint. All data points were N = 3, except for +/+, +/+ week 1 and week 2 (N = 4); +/+, +/−day 0 (N = 8) and week 4 (N = 4); −/−, +/−day 0 (N = 6), week 1 (N = 4) and week 4 (N = 5). The graph is mean ± SEM. b Representative histology of RUNX1T1 staining in ganglia from mice homozygous for the Th-MYCN transgene, and either wild-type or heterozygous for Runx1t1 from day 0 and 4 weeks of age.

Journal: Nature communications

Article Title: The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis.

doi: 10.1038/s41467-024-49871-0

Figure Lengend Snippet: Fig. 2 | Runx1t1 loss reverses MYCN-mediated sustained hyperplasia and induces ganglia neurite extension. a The percentage neuroblast hyperplasia scored from homozygous Th-MYCN (+/+) mice or littermate mice lacking the MYCN transgene (−/−), with either wild-type (+/+) or heterozygous loss (+/−) of Runx1t1. Scoring of N = 3–8 independent mice was performed for each genotype and timepoint. All data points were N = 3, except for +/+, +/+ week 1 and week 2 (N = 4); +/+, +/−day 0 (N = 8) and week 4 (N = 4); −/−, +/−day 0 (N = 6), week 1 (N = 4) and week 4 (N = 5). The graph is mean ± SEM. b Representative histology of RUNX1T1 staining in ganglia from mice homozygous for the Th-MYCN transgene, and either wild-type or heterozygous for Runx1t1 from day 0 and 4 weeks of age.

Article Snippet: Samples were embedded in paraffin, sectioned, and stained with H&E or for MYCN (rabbit polyclonal antibody, 10159-2-AP, Proteintech, 1:1000) and RUNX1T1 (as described above).

Techniques: Staining

Multiple C2 domains mediate otoferlin–Loop1.3 interaction. (A–D) Binding curves for immobilized YFP-otoferlin C2A (A), C2B (B), C2D (C), and C2F (D) domains titrated against Loop1.3 at 0.1–50 µM free calcium. Data are fit with a Langmuir isotherm (solid lines). Insets depict 0–10 µM for clarity. Each experimental data point represents the mean value of n = 3. (E and F) Binding curves for immobilized YFP-otoferlin C2C and C2E domains titrated against Loop1.3. Colocalization between Loop1.3 and YFP-otoferlin (otoferlin amino acids 1–1,885) is included for comparison.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Article Title: Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels

doi: 10.1073/pnas.1703240114

Figure Lengend Snippet: Multiple C2 domains mediate otoferlin–Loop1.3 interaction. (A–D) Binding curves for immobilized YFP-otoferlin C2A (A), C2B (B), C2D (C), and C2F (D) domains titrated against Loop1.3 at 0.1–50 µM free calcium. Data are fit with a Langmuir isotherm (solid lines). Insets depict 0–10 µM for clarity. Each experimental data point represents the mean value of n = 3. (E and F) Binding curves for immobilized YFP-otoferlin C2C and C2E domains titrated against Loop1.3. Colocalization between Loop1.3 and YFP-otoferlin (otoferlin amino acids 1–1,885) is included for comparison.

Article Snippet: Otoferlin amino acids 1–1,885 were amplified via PCR from a PCDNA3 vector and subcloned into the HindIII and BamHI sites of the CKAR vector acquired from Addgene (plasmid 14860).

Techniques: Binding Assay