Journal: bioRxiv

Article Title: Chemotherapy coupled to macrophage inhibition leads to B cell-mediated T cell memory activation and durable triple negative breast cancer regression

doi: 10.1101/2021.02.22.432300

Figure Lengend Snippet: a , Treatment response using standard of care drugs on T11 mammary tumors. b , Immunohistochemistry for F4/80+ TAMs and CD8+ T Cells on p53-/- tumor models. c , T cell gating scheme. d , Myeloid cell gating scheme. e , Co-culture of GFP+ T12 tumor cells and GFP targeting T cells with or without Phosphoramide Mustard (PM). Each treatment was performed in triplicates and repeated twice. f , Flow cytometry analysis of CD8+ and CD4+ T cells before and after low-dose CTX treatment, n = 6-7 mice per group. g , Quantification of TAMs upon antibody depletion of CD4+ T cells after treatment. h , Quantification of CD8+ T cells after CD4+ T cell depletion after treatment. i,j , Quantification of CD8+ T memory cell subsets before and after treatment, n = 4-5 mice per group. Unpaired t-test was used to determine significance. k,l ,, Reduced tumor volume and improved survival in T12 mammary tumor bearing mice after treatment with CTX and 3.3X lower PXB (75 ppm).

Article Snippet: After 24 hrs, T cells were added at a 10:1 effector/target ratio with 10,000; 1,000; 100; 10; 1; 0 m of phosphoramide mustard (#M123069, MuseChem).

Techniques: Immunohistochemistry, Co-Culture Assay, Flow Cytometry

Journal: iScience

Article Title: SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation

doi: 10.1016/j.isci.2025.111935

Figure Lengend Snippet: Screening of αSyn-processing enzyme

Article Snippet: Mergepta , MuseChem , R058848.

Techniques: Inhibition, Activity Assay, Ubiquitin Proteomics

Journal: iScience

Article Title: SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation

doi: 10.1016/j.isci.2025.111935

Figure Lengend Snippet:

Article Snippet: Mergepta , MuseChem , R058848.

Techniques: Plasmid Preparation, Recombinant, Derivative Assay, Silver Staining, H&E Stain, Knock-Out, Software, Sequencing, Fluorsave

Journal: Neurotoxicity research

Article Title: The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity

doi: 10.1007/s12640-020-00272-3

Figure Lengend Snippet: Chemicals used and abbreviations

Article Snippet: Chemicals Chemicals included Ferbam from TCI America, Portland, OR; ML385 and MS275 from Toris Biosciences, Minneapolis, MN; APTO235 (MedChemExpress, Princeton, NJ); and sankel (Muse Chem, Fairfield, NJ).

Techniques:

Journal: Neurotoxicity research

Article Title: The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity

doi: 10.1007/s12640-020-00272-3

Figure Lengend Snippet: MT1G mRNA expression responses to chelated and unchelated metals. a dLUHMES cells were treated for 6 h with toxicants MHG, CuCl2, DDC, or ziram; and with vehicle, white bars; APTO-253 5 μM, speckled bars; or ML385 5 μM, dark hatched bars. MT1G expression was measured by qRT-PCR. Treatments were MHG 2 μM; CuCl2 5 μM; DDC 5 μM; NiDDC2 5 μM; ziram 5 μM; b undifferentiated LUHMES cells subjected to the same treatments

Article Snippet: Chemicals Chemicals included Ferbam from TCI America, Portland, OR; ML385 and MS275 from Toris Biosciences, Minneapolis, MN; APTO235 (MedChemExpress, Princeton, NJ); and sankel (Muse Chem, Fairfield, NJ).

Techniques: Expressing, Quantitative RT-PCR