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Image Search Results
Journal: Frontiers in cell and developmental biology
Article Title: Effect of AMH on primordial follicle populations in mouse ovaries and human pre-pubertal ovarian xenografts during doxorubicin treatment.
doi: 10.3389/fcell.2024.1449156
Figure Lengend Snippet: FIGURE 2 Treatment regimen for administration of anti-Müllerian hormone (AMH) and/or doxorubicin (DXR) to SCID mice (severe combined immunodeficient) containing human ovarian transplants. Ten days after human ovarian tissue was xenotransplanted into SCID mice, animals were intraperitoneally (IP) injected daily with PBS or rhAMH for 8 days with an additional single IP injection of PBS or DXR on the second day.
Article Snippet:
Techniques: Injection
Journal: Frontiers in cell and developmental biology
Article Title: Effect of AMH on primordial follicle populations in mouse ovaries and human pre-pubertal ovarian xenografts during doxorubicin treatment.
doi: 10.3389/fcell.2024.1449156
Figure Lengend Snippet: FIGURE 3 Analysis of mouse ovarian follicles in cultured pre-pubertal ovaries treated with DXR and AMH stained with H and E. (A) Representative images of morphologically healthy follicles (scale bar = 25 μm): i: Primordial follicles. ii-iv: Growing follicles (ii: Transitional; iii: Primary; iv: Secondary). (B) Unhealthy follicles (scale bar = 100 μm): black arrows denote pyknotic granulosa cells, red arrows denote atretic oocytes. (C) Total number of morphologically healthy primordial follicles in mouse ovaries treated with different concentrations of DXR. Values are presented as Mean ± S.E.M. Control n = 3; 50 ng/mL DXR n = 3; 100 ng/mL DXR n = 5; 200 ng/mL DXR n = 3. (D) Number of morphologically healthy primordial follicles in mouse ovaries cultured with different concentrations of rhAMH and with or without exposure to DXR. Values represent Mean ± S.E.M ns = not significant, *P < 0.05, ***P < 0.001, ****P < 0.0001.
Article Snippet:
Techniques: Cell Culture, Staining, Control