mif antagonist Search Results


mif inhibitor iso  (MedChemExpress)
95
MedChemExpress mif inhibitor iso
MIF, migration inhibitory factor; ASMC, airway smooth muscle cell; TEM, transmission electron microscope; OVA, ovalbumin; <t>ISO-1,</t> (S,R)3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester; DAPI, 4′,6-diamidino-2-phenylindole. * P < 0.05 vs. MIF 0 ng/mL; † P < 0.001 vs. MIF 0 ng/mL; ‡ P < 0.001 vs. control; § P < 0.001 vs. the OVA group.
Mif Inhibitor Iso, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mif+antagonist/ISO-1/pmc07680835-54-1-7
Average 95 stars, based on 1 article reviews
mif inhibitor iso - by Bioz Stars, 2026-11
95/100 stars
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iso 1  (TargetMol)
94
TargetMol iso 1
A Infiltrating status of M1 (marked by F4/80 and INOS) and M2 (marked by F4/80 and CD206) macrophages in nude-mouse xenografts derived from A549 DEFB1-NC/KO/ROE cells (scale bar: 200 μm); B CoIP verification of the interaction between DEFB1 and MIF in A549/PC-9 cells treated with exogenously added 3× Flag-tagged DEFB1 (200 pg/mL); C AlphaFold 3 prediction of the interaction mode between DEFB1 and MIF; D Schematic diagram of an in vitro co-culture model of lung adenocarcinoma cells and THP-1 derived macrophages; E , F Flow Cytometry and qRT-PCR for evaluating the effects of DEFB1 and/or MIF inhibitor <t>(ISO-1)</t> on M1 polarization of THP-1 M0 cells co-cultured with A549 cells; G , H Flow Cytometry and qRT-PCR for evaluating the effects of DEFB1 and/or ISO-1 on M2 polarization of THP-1 M0 cells co-cultured with A549 cells; I , J Effects of DEFB1-KO, PPL-KO, and/or ISO-1 on the in vivo proliferative capacity in nude-mouse CDX model. Statistical analysis: ( F , H , and G ) One-way ANOVA test and Bonferroni correction.
Iso 1, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mif+antagonist/ISO-1/pmc13223247-119-0-5
Average 94 stars, based on 1 article reviews
iso 1 - by Bioz Stars, 2026-11
94/100 stars
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novel mif antagonists  (Piramal Phytocare)
90
Piramal Phytocare novel mif antagonists
A Infiltrating status of M1 (marked by F4/80 and INOS) and M2 (marked by F4/80 and CD206) macrophages in nude-mouse xenografts derived from A549 DEFB1-NC/KO/ROE cells (scale bar: 200 μm); B CoIP verification of the interaction between DEFB1 and MIF in A549/PC-9 cells treated with exogenously added 3× Flag-tagged DEFB1 (200 pg/mL); C AlphaFold 3 prediction of the interaction mode between DEFB1 and MIF; D Schematic diagram of an in vitro co-culture model of lung adenocarcinoma cells and THP-1 derived macrophages; E , F Flow Cytometry and qRT-PCR for evaluating the effects of DEFB1 and/or MIF inhibitor <t>(ISO-1)</t> on M1 polarization of THP-1 M0 cells co-cultured with A549 cells; G , H Flow Cytometry and qRT-PCR for evaluating the effects of DEFB1 and/or ISO-1 on M2 polarization of THP-1 M0 cells co-cultured with A549 cells; I , J Effects of DEFB1-KO, PPL-KO, and/or ISO-1 on the in vivo proliferative capacity in nude-mouse CDX model. Statistical analysis: ( F , H , and G ) One-way ANOVA test and Bonferroni correction.
Novel Mif Antagonists, supplied by Piramal Phytocare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mif+antagonist/novel+mif+antagonists/pm21277206-22-21-59
Average 90 stars, based on 1 article reviews
novel mif antagonists - by Bioz Stars, 2026-11
90/100 stars
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mif antagonist iii, 4-ipp  (Biosynth Carbosynth)
N/A
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mif antagonist, iso-1  (Biosynth Carbosynth)
N/A
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mif antagonist  (Cayman Chemical)
N/A
MIF Antagonist
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mif antagonist, iso-1  (Santa Cruz Biotechnology)
N/A
MIF Antagonist, ISO-1 is a cell-permeable isoxazoline compound that displays anti-inflammatory properties. MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and
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mif antagonist, iso-1  (1PlusChem LLC)
N/A
MIF Antagonist, ISO-1
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mif antagonist, iso-1  (Thermo Fisher)
N/A
MIF Antagonist, ISO-1
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Image Search Results


MIF, migration inhibitory factor; ASMC, airway smooth muscle cell; TEM, transmission electron microscope; OVA, ovalbumin; ISO-1, (S,R)3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester; DAPI, 4′,6-diamidino-2-phenylindole. * P < 0.05 vs. MIF 0 ng/mL; † P < 0.001 vs. MIF 0 ng/mL; ‡ P < 0.001 vs. control; § P < 0.001 vs. the OVA group.

Journal: Allergy, Asthma & Immunology Research

Article Title: The Role of Macrophage Migration Inhibitory Factor (MIF) in Asthmatic Airway Remodeling

doi: 10.4168/aair.2021.13.1.88

Figure Lengend Snippet: MIF, migration inhibitory factor; ASMC, airway smooth muscle cell; TEM, transmission electron microscope; OVA, ovalbumin; ISO-1, (S,R)3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester; DAPI, 4′,6-diamidino-2-phenylindole. * P < 0.05 vs. MIF 0 ng/mL; † P < 0.001 vs. MIF 0 ng/mL; ‡ P < 0.001 vs. control; § P < 0.001 vs. the OVA group.

Article Snippet: The MIF inhibitor ISO-1 was purchased from medChemExpress (Monmouth Junction, NJ, USA).

Techniques: Migration, Transmission Assay, Microscopy, Control

MIF, migration inhibitory factor; ASMC, airway smooth muscle cell; ELISA, enzyme-linked immunosorbent assay; IL, interleukin; NC, negative control; ISO-1, (S,R)3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester; q-PCR, quantitative polymerase chain reaction; shRNA, short hairpin RNA. * P < 0.001 vs. the control group; † P < 0.01 vs. the IL-4 group; ‡ P < 0.001 vs. the IL-4 group; § P < 0.01 vs. the IL-4+shRNA-NC group.

Journal: Allergy, Asthma & Immunology Research

Article Title: The Role of Macrophage Migration Inhibitory Factor (MIF) in Asthmatic Airway Remodeling

doi: 10.4168/aair.2021.13.1.88

Figure Lengend Snippet: MIF, migration inhibitory factor; ASMC, airway smooth muscle cell; ELISA, enzyme-linked immunosorbent assay; IL, interleukin; NC, negative control; ISO-1, (S,R)3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester; q-PCR, quantitative polymerase chain reaction; shRNA, short hairpin RNA. * P < 0.001 vs. the control group; † P < 0.01 vs. the IL-4 group; ‡ P < 0.001 vs. the IL-4 group; § P < 0.01 vs. the IL-4+shRNA-NC group.

Article Snippet: The MIF inhibitor ISO-1 was purchased from medChemExpress (Monmouth Junction, NJ, USA).

Techniques: Migration, Enzyme-linked Immunosorbent Assay, Negative Control, Real-time Polymerase Chain Reaction, shRNA, Control

The promotive effects of macrophage-derived MIF on ASMC autophagy determined by immunofluorescence. (A) In the ISO-1-mediated MIF inhibition model, the images of GFP-RFP-LC3-transfected cells showed that ASMC autophagy was decreased in the IL-4+ISO-1 group compared with the IL-4 group (200 ×, scale bar, 10 μm). (B) In the MIF-knock-down model, the IL-4+shRNA-MIF group displayed decreased ASMC autophagy (GFP-RFP-LC3 reporting system) compared with the IL-4 or IL-4+shRNA-NC group (200 ×, scale bar, 10 μm).

Journal: Allergy, Asthma & Immunology Research

Article Title: The Role of Macrophage Migration Inhibitory Factor (MIF) in Asthmatic Airway Remodeling

doi: 10.4168/aair.2021.13.1.88

Figure Lengend Snippet: The promotive effects of macrophage-derived MIF on ASMC autophagy determined by immunofluorescence. (A) In the ISO-1-mediated MIF inhibition model, the images of GFP-RFP-LC3-transfected cells showed that ASMC autophagy was decreased in the IL-4+ISO-1 group compared with the IL-4 group (200 ×, scale bar, 10 μm). (B) In the MIF-knock-down model, the IL-4+shRNA-MIF group displayed decreased ASMC autophagy (GFP-RFP-LC3 reporting system) compared with the IL-4 or IL-4+shRNA-NC group (200 ×, scale bar, 10 μm).

Article Snippet: The MIF inhibitor ISO-1 was purchased from medChemExpress (Monmouth Junction, NJ, USA).

Techniques: Derivative Assay, Immunofluorescence, Inhibition, Transfection, Knockdown, shRNA

A Infiltrating status of M1 (marked by F4/80 and INOS) and M2 (marked by F4/80 and CD206) macrophages in nude-mouse xenografts derived from A549 DEFB1-NC/KO/ROE cells (scale bar: 200 μm); B CoIP verification of the interaction between DEFB1 and MIF in A549/PC-9 cells treated with exogenously added 3× Flag-tagged DEFB1 (200 pg/mL); C AlphaFold 3 prediction of the interaction mode between DEFB1 and MIF; D Schematic diagram of an in vitro co-culture model of lung adenocarcinoma cells and THP-1 derived macrophages; E , F Flow Cytometry and qRT-PCR for evaluating the effects of DEFB1 and/or MIF inhibitor (ISO-1) on M1 polarization of THP-1 M0 cells co-cultured with A549 cells; G , H Flow Cytometry and qRT-PCR for evaluating the effects of DEFB1 and/or ISO-1 on M2 polarization of THP-1 M0 cells co-cultured with A549 cells; I , J Effects of DEFB1-KO, PPL-KO, and/or ISO-1 on the in vivo proliferative capacity in nude-mouse CDX model. Statistical analysis: ( F , H , and G ) One-way ANOVA test and Bonferroni correction.

Journal: Cell Death & Disease

Article Title: Unveiling DEFB1 as a novel driver and promising therapeutic target in lung adenocarcinoma

doi: 10.1038/s41419-026-08748-4

Figure Lengend Snippet: A Infiltrating status of M1 (marked by F4/80 and INOS) and M2 (marked by F4/80 and CD206) macrophages in nude-mouse xenografts derived from A549 DEFB1-NC/KO/ROE cells (scale bar: 200 μm); B CoIP verification of the interaction between DEFB1 and MIF in A549/PC-9 cells treated with exogenously added 3× Flag-tagged DEFB1 (200 pg/mL); C AlphaFold 3 prediction of the interaction mode between DEFB1 and MIF; D Schematic diagram of an in vitro co-culture model of lung adenocarcinoma cells and THP-1 derived macrophages; E , F Flow Cytometry and qRT-PCR for evaluating the effects of DEFB1 and/or MIF inhibitor (ISO-1) on M1 polarization of THP-1 M0 cells co-cultured with A549 cells; G , H Flow Cytometry and qRT-PCR for evaluating the effects of DEFB1 and/or ISO-1 on M2 polarization of THP-1 M0 cells co-cultured with A549 cells; I , J Effects of DEFB1-KO, PPL-KO, and/or ISO-1 on the in vivo proliferative capacity in nude-mouse CDX model. Statistical analysis: ( F , H , and G ) One-way ANOVA test and Bonferroni correction.

Article Snippet: ISO-1 (#T3680) was obtained from TargetMol (Boston, Massachusetts, USA).

Techniques: Derivative Assay, In Vitro, Co-culture Assay, Flow Cytometry, Quantitative RT-PCR, Cell Culture, In Vivo, Analysis, Immunofluorescence, Co-Immunoprecipitation Assay, Real-time Polymerase Chain Reaction, Xenograft Assay