midazolam Search Results


hydroxymidazolam  (Toronto Research Chemicals)
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Toronto Research Chemicals hydroxymidazolam
Hydroxymidazolam, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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oh midazolam d5  (Toronto Research Chemicals)
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Toronto Research Chemicals oh midazolam d5
Oh Midazolam D5, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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midazolam  (Toronto Research Chemicals)
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Toronto Research Chemicals midazolam
Midazolam, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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midazolam d6  (Toronto Research Chemicals)
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Toronto Research Chemicals midazolam d6
Midazolam D6, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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midazolam  (Tocris)
92
Tocris midazolam
Fig. 2. Preliminary MBI screening assays conducted with (A) CYP3A4, (B) CYP2C9, and (C) CYP2J2. Specific probe substrates used in secondary reaction mixtures were 25 mM <t>midazolam</t> (CYP3A4), 50 mM diclofenac (CYP2C9), and 50 mM rivaroxaban (CYP2J2). The time-dependent decrease in CYP3A4 activity elicited by BBR is apparent. Each point in (A–C) represents the mean and S.D. of triplicate experiments.
Midazolam, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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internal standard midazolam d6  (Toronto Research Chemicals)
86
Toronto Research Chemicals internal standard midazolam d6
Test drugs caffeine (metabolised by CYP1A2) and <t>midazolam</t> (metabolised by CYP3A) was administered 2 hours after the methamphetamine dose and plasma samples were collected 3, 4, 5, 6 and 8 hours after methamphetamine dose. Error bars represent standard error of mean (SEM).
Internal Standard Midazolam D6, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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midazolam hydrochloride  (Tocris)
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Tocris midazolam hydrochloride
Test drugs caffeine (metabolised by CYP1A2) and <t>midazolam</t> (metabolised by CYP3A) was administered 2 hours after the methamphetamine dose and plasma samples were collected 3, 4, 5, 6 and 8 hours after methamphetamine dose. Error bars represent standard error of mean (SEM).
Midazolam Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1 oh midazolam d5  (Toronto Research Chemicals)
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Test drugs caffeine (metabolised by CYP1A2) and <t>midazolam</t> (metabolised by CYP3A) was administered 2 hours after the methamphetamine dose and plasma samples were collected 3, 4, 5, 6 and 8 hours after methamphetamine dose. Error bars represent standard error of mean (SEM).
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hydroxy midazolam  (Toronto Research Chemicals)
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Toronto Research Chemicals hydroxy midazolam
Test drugs caffeine (metabolised by CYP1A2) and <t>midazolam</t> (metabolised by CYP3A) was administered 2 hours after the methamphetamine dose and plasma samples were collected 3, 4, 5, 6 and 8 hours after methamphetamine dose. Error bars represent standard error of mean (SEM).
Hydroxy Midazolam, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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midazolam  (Lipomed)
93
Lipomed midazolam
Test drugs caffeine (metabolised by CYP1A2) and <t>midazolam</t> (metabolised by CYP3A) was administered 2 hours after the methamphetamine dose and plasma samples were collected 3, 4, 5, 6 and 8 hours after methamphetamine dose. Error bars represent standard error of mean (SEM).
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Image Search Results


Fig. 2. Preliminary MBI screening assays conducted with (A) CYP3A4, (B) CYP2C9, and (C) CYP2J2. Specific probe substrates used in secondary reaction mixtures were 25 mM midazolam (CYP3A4), 50 mM diclofenac (CYP2C9), and 50 mM rivaroxaban (CYP2J2). The time-dependent decrease in CYP3A4 activity elicited by BBR is apparent. Each point in (A–C) represents the mean and S.D. of triplicate experiments.

Journal: Molecular pharmacology

Article Title: Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone.

doi: 10.1124/molpharm.120.000086

Figure Lengend Snippet: Fig. 2. Preliminary MBI screening assays conducted with (A) CYP3A4, (B) CYP2C9, and (C) CYP2J2. Specific probe substrates used in secondary reaction mixtures were 25 mM midazolam (CYP3A4), 50 mM diclofenac (CYP2C9), and 50 mM rivaroxaban (CYP2J2). The time-dependent decrease in CYP3A4 activity elicited by BBR is apparent. Each point in (A–C) represents the mean and S.D. of triplicate experiments.

Article Snippet: Midazolam was purchased from Tocris Bioscience (Bristol, UK).

Techniques: Activity Assay

Test drugs caffeine (metabolised by CYP1A2) and midazolam (metabolised by CYP3A) was administered 2 hours after the methamphetamine dose and plasma samples were collected 3, 4, 5, 6 and 8 hours after methamphetamine dose. Error bars represent standard error of mean (SEM).

Journal: PLoS ONE

Article Title: Methamphetamine administration increases hepatic CYP1A2 but not CYP3A activity in female guinea pigs

doi: 10.1371/journal.pone.0233010

Figure Lengend Snippet: Test drugs caffeine (metabolised by CYP1A2) and midazolam (metabolised by CYP3A) was administered 2 hours after the methamphetamine dose and plasma samples were collected 3, 4, 5, 6 and 8 hours after methamphetamine dose. Error bars represent standard error of mean (SEM).

Article Snippet: Acetonitrile (Honeywell Australia, North Ryde, Australia); caffeine citrate (Biomed Limited, Auckland, New Zealand); internal standard caffeine d3 (Toronto Research Chemicals, Toronto, Canada); Formic acid (Sigma Aldrich, New South Wales, Australia); isoflurane (Attane TM , Bayer, Auckland, New Zealand); KiCqStart SYBR Green qPCR ReadyMix Low Rox (Sigma Aldrich, New South Wales, Australia); methamphetamine (BDG Synthesis, Wellington, New Zealand); internal standard methamphetamine d5 (Toronto Research Chemicals, Toronto, Canada); midazolam (Claris, AFT Pharmaceutical Limited, Auckland, New Zealand); internal standard midazolam d6 (Toronto Research Chemicals, Toronto, Canada); internal standard paraxanthine d3 (Toronto Research Chemicals, Toronto, Canada); QIAZOL Lysis Reagent (QIAGEN, Victoria); RNeasy Mini Kit (QIAGEN, Victoria); sodium pentobarbital (Pentobarb, Provet, Palmerston North, New Zealand).

Techniques: Clinical Proteomics