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InformationMGCD-265 is a potent, multi-target and ATP-competitive inhibitor ofc-MetandVEGFR1/2/3withIC50of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. Phase 1/2.In vitroMGCD-265 is a multi-target inhibitor of receptor tyrosine kinases. MGCD-265 potently inhibits
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N/A
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MGCD-265 analog is a potent and oral bioavailable inhibitor of c-Met and VEGFR2 tyrosine kinases, with IC50 s of 29 nM and 10 nM, respectively. MGCD-265 analog has significant antitumor activity.
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N/A
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MGCD-265 is a potent, multi-target, and ATP-competitive receptor tyrosine kinase inhibitor of Met, Flt-1, Flt-4, Flk-1, Ron, and Tie-2 (IC50 = 1 nM - 7 nM).
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N/A
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Application：MGCD-265 analog is a potent and oral active inhibitor of c-Met and VEGFR2 tyrosine kinases, with IC50s of 29 nM and 10 nM, respectively. MGCD-265 analog has significant antitumor activity
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N/A
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MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively and also inhibits Ron and Tie2.
|
Buy from Supplier |
N/A
|
MGCD-265 analog is a potent and oral active inhibitor of c-Met and VEGFR2 tyrosine kinases.
|
Buy from Supplier |
Image Search Results
Journal: Cold Spring Harbor Molecular Case Studies
Article Title: Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making
doi: 10.1101/mcs.a002626
Figure Lengend Snippet: POG analyses in all five adenoid cystic carcinoma cases yielded informative and actionable results
Article Snippet: Patient 3 exhibited aberrations in MET expression and was subsequently enrolled in a phase I clinical trial with
Techniques: Biomarker Discovery, Over Expression