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mertk-apc (ds5mmer  (Becton Dickinson)
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Becton Dickinson mertk-apc (ds5mmer
Monocyte-derived APCs expressed gene signatures for both dendritic cells and macrophages. (A–F) The gene expression level of Itgax (A) , H2-Ab1 (B) , H2-Aa (C) , Cd68 (D) , <t>Mertk</t> (E) , and Cd74 (F) in monocytes isolated from the bone marrow (BM-Mono) or spinal cords (SC-Mono), and the monocyte-derived APCs isolated from the spinal cords <t>(SC-APC)</t> at days 14–15 following EAE induction. Shown are TPM values from RNA-Seq analysis. (G–J) Spinal cord cells were isolated at days 14–15 (G) or day 7 (H) following EAE induction. The expression of surface markers for dendritic cells (CD11c, MHC II) and macrophages (MerTK, CD24) in the CD45 hi CD11b hi CD64 + Ly6G − cells or the CD45 hi CD11b hi CD64 − Ly6G − cells was determined. Shown are representative plots from three independent experiments, with a total of 10–11 animals in each time point. (I) Percentage of cells expressing MerTK and CD24 within the CD11c/MHCII subpopulations from individual animals is shown. (J) Percentage of cells expressing CD11c and MHCII within the CD64 hi or CD64 lo/− populations from individual animals is shown. * P < 0.05; ** P < 0.01; *** P < 0.001. NS, not statistically different.
Mertk Apc (Ds5mmer, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mertk-apc/pmc06889845-55-43-24?v=Becton+Dickinson
Average 90 stars, based on 1 article reviews
mertk-apc (ds5mmer - by Bioz Stars, 2026-07
90/100 stars
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Monocyte-derived APCs expressed gene signatures for both dendritic cells and macrophages. (A–F) The gene expression level of Itgax (A) , H2-Ab1 (B) , H2-Aa (C) , Cd68 (D) , Mertk (E) , and Cd74 (F) in monocytes isolated from the bone marrow (BM-Mono) or spinal cords (SC-Mono), and the monocyte-derived APCs isolated from the spinal cords (SC-APC) at days 14–15 following EAE induction. Shown are TPM values from RNA-Seq analysis. (G–J) Spinal cord cells were isolated at days 14–15 (G) or day 7 (H) following EAE induction. The expression of surface markers for dendritic cells (CD11c, MHC II) and macrophages (MerTK, CD24) in the CD45 hi CD11b hi CD64 + Ly6G − cells or the CD45 hi CD11b hi CD64 − Ly6G − cells was determined. Shown are representative plots from three independent experiments, with a total of 10–11 animals in each time point. (I) Percentage of cells expressing MerTK and CD24 within the CD11c/MHCII subpopulations from individual animals is shown. (J) Percentage of cells expressing CD11c and MHCII within the CD64 hi or CD64 lo/− populations from individual animals is shown. * P < 0.05; ** P < 0.01; *** P < 0.001. NS, not statistically different.

Journal: Frontiers in Immunology

Article Title: Monocytes and Monocyte-Derived Antigen-Presenting Cells Have Distinct Gene Signatures in Experimental Model of Multiple Sclerosis

doi: 10.3389/fimmu.2019.02779

Figure Lengend Snippet: Monocyte-derived APCs expressed gene signatures for both dendritic cells and macrophages. (A–F) The gene expression level of Itgax (A) , H2-Ab1 (B) , H2-Aa (C) , Cd68 (D) , Mertk (E) , and Cd74 (F) in monocytes isolated from the bone marrow (BM-Mono) or spinal cords (SC-Mono), and the monocyte-derived APCs isolated from the spinal cords (SC-APC) at days 14–15 following EAE induction. Shown are TPM values from RNA-Seq analysis. (G–J) Spinal cord cells were isolated at days 14–15 (G) or day 7 (H) following EAE induction. The expression of surface markers for dendritic cells (CD11c, MHC II) and macrophages (MerTK, CD24) in the CD45 hi CD11b hi CD64 + Ly6G − cells or the CD45 hi CD11b hi CD64 − Ly6G − cells was determined. Shown are representative plots from three independent experiments, with a total of 10–11 animals in each time point. (I) Percentage of cells expressing MerTK and CD24 within the CD11c/MHCII subpopulations from individual animals is shown. (J) Percentage of cells expressing CD11c and MHCII within the CD64 hi or CD64 lo/− populations from individual animals is shown. * P < 0.05; ** P < 0.01; *** P < 0.001. NS, not statistically different.

Article Snippet: Isolated cells were first incubated with anti-mouse CD16/CD32 (2.4G2, Fc block), then stained with the following antibodies to identify monocytes and monocyte-derived APCs using BD LSRFortessa: CD45-PE/Cy7 (30-F11), CD11b-FITC (M1/70), CD64-APC (X54-5/7.1), Ly6C-PE (HK1.4), Ly6G-BV510 (1A8), CCR2-BV421 (SA203G11), CD11c-Percp/Cy5.5 (N418), MHC II-BV510 (M5/114.15.2), MerTK-APC (DS5MMER), and CD24-BV421 (M1/69).

Techniques: Derivative Assay, Expressing, Isolation, RNA Sequencing Assay