mertk apc Search Results



90
Becton Dickinson mertk-apc (ds5mmer
Monocyte-derived APCs expressed gene signatures for both dendritic cells and macrophages. (A–F) The gene expression level of Itgax (A) , H2-Ab1 (B) , H2-Aa (C) , Cd68 (D) , <t>Mertk</t> (E) , and Cd74 (F) in monocytes isolated from the bone marrow (BM-Mono) or spinal cords (SC-Mono), and the monocyte-derived APCs isolated from the spinal cords <t>(SC-APC)</t> at days 14–15 following EAE induction. Shown are TPM values from RNA-Seq analysis. (G–J) Spinal cord cells were isolated at days 14–15 (G) or day 7 (H) following EAE induction. The expression of surface markers for dendritic cells (CD11c, MHC II) and macrophages (MerTK, CD24) in the CD45 hi CD11b hi CD64 + Ly6G − cells or the CD45 hi CD11b hi CD64 − Ly6G − cells was determined. Shown are representative plots from three independent experiments, with a total of 10–11 animals in each time point. (I) Percentage of cells expressing MerTK and CD24 within the CD11c/MHCII subpopulations from individual animals is shown. (J) Percentage of cells expressing CD11c and MHCII within the CD64 hi or CD64 lo/− populations from individual animals is shown. * P < 0.05; ** P < 0.01; *** P < 0.001. NS, not statistically different.
Mertk Apc (Ds5mmer, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mertk+apc/mertk+apc++ds5mmer+antibody/pmc06889845-55-43-24
Average 90 stars, based on 1 article reviews
mertk-apc (ds5mmer - by Bioz Stars, 2026-09
90/100 stars
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Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis
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Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis
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APC anti-human MERTK [590H11G1E3]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 25 tests
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Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis
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APC anti-mouse MERTK (Mer) [2B10C42]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC; Size: 25 μg
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N/A
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis
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Monocyte-derived APCs expressed gene signatures for both dendritic cells and macrophages. (A–F) The gene expression level of Itgax (A) , H2-Ab1 (B) , H2-Aa (C) , Cd68 (D) , Mertk (E) , and Cd74 (F) in monocytes isolated from the bone marrow (BM-Mono) or spinal cords (SC-Mono), and the monocyte-derived APCs isolated from the spinal cords (SC-APC) at days 14–15 following EAE induction. Shown are TPM values from RNA-Seq analysis. (G–J) Spinal cord cells were isolated at days 14–15 (G) or day 7 (H) following EAE induction. The expression of surface markers for dendritic cells (CD11c, MHC II) and macrophages (MerTK, CD24) in the CD45 hi CD11b hi CD64 + Ly6G − cells or the CD45 hi CD11b hi CD64 − Ly6G − cells was determined. Shown are representative plots from three independent experiments, with a total of 10–11 animals in each time point. (I) Percentage of cells expressing MerTK and CD24 within the CD11c/MHCII subpopulations from individual animals is shown. (J) Percentage of cells expressing CD11c and MHCII within the CD64 hi or CD64 lo/− populations from individual animals is shown. * P < 0.05; ** P < 0.01; *** P < 0.001. NS, not statistically different.

Journal: Frontiers in Immunology

Article Title: Monocytes and Monocyte-Derived Antigen-Presenting Cells Have Distinct Gene Signatures in Experimental Model of Multiple Sclerosis

doi: 10.3389/fimmu.2019.02779

Figure Lengend Snippet: Monocyte-derived APCs expressed gene signatures for both dendritic cells and macrophages. (A–F) The gene expression level of Itgax (A) , H2-Ab1 (B) , H2-Aa (C) , Cd68 (D) , Mertk (E) , and Cd74 (F) in monocytes isolated from the bone marrow (BM-Mono) or spinal cords (SC-Mono), and the monocyte-derived APCs isolated from the spinal cords (SC-APC) at days 14–15 following EAE induction. Shown are TPM values from RNA-Seq analysis. (G–J) Spinal cord cells were isolated at days 14–15 (G) or day 7 (H) following EAE induction. The expression of surface markers for dendritic cells (CD11c, MHC II) and macrophages (MerTK, CD24) in the CD45 hi CD11b hi CD64 + Ly6G − cells or the CD45 hi CD11b hi CD64 − Ly6G − cells was determined. Shown are representative plots from three independent experiments, with a total of 10–11 animals in each time point. (I) Percentage of cells expressing MerTK and CD24 within the CD11c/MHCII subpopulations from individual animals is shown. (J) Percentage of cells expressing CD11c and MHCII within the CD64 hi or CD64 lo/− populations from individual animals is shown. * P < 0.05; ** P < 0.01; *** P < 0.001. NS, not statistically different.

Article Snippet: Isolated cells were first incubated with anti-mouse CD16/CD32 (2.4G2, Fc block), then stained with the following antibodies to identify monocytes and monocyte-derived APCs using BD LSRFortessa: CD45-PE/Cy7 (30-F11), CD11b-FITC (M1/70), CD64-APC (X54-5/7.1), Ly6C-PE (HK1.4), Ly6G-BV510 (1A8), CCR2-BV421 (SA203G11), CD11c-Percp/Cy5.5 (N418), MHC II-BV510 (M5/114.15.2), MerTK-APC (DS5MMER), and CD24-BV421 (M1/69).

Techniques: Derivative Assay, Expressing, Isolation, RNA Sequencing Assay