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Image Search Results
Journal: iScience
Article Title: Dietary fiber reduces mortality from secondary sepsis in a murine model of Clostridioides difficile infection
doi: 10.1016/j.isci.2026.115258
Figure Lengend Snippet: Plasma markers of systemic inflammation and kidney injury in CDI mice across diets (A) PCoA of Canberra distances of mean-normalized sepsis/immune marker concentrations. Points are colored by diet, and shapes indicate whether mice were humanely euthanized due to clinical sickness or survived until the experimental endpoint. Vectors show the correlation of each measured factor with PC1 and PC2, with the vector length indicating the relative strength of the correlation. Only statistically significant vectors are shown (multiple regression with Benjamini-Hochberg multiple test correction, p.adj. < 0.05). (B) Plasma concentration of each marker that significantly differed between diets (blood urea nitrogen (BUN), and immune factors sCD14, CXCL1, IL-10, IL-1B, IL-6, and TNF-a) at sacrifice. Pairwise comparisons of concentrations between diets were calculated using Kruskal-Wallis and Dunn’s post hoc tests, with p -value corrections conducted via Benjamini and Hochberg. Boxplot lines (from top to bottom) depict the 75 th , 50 th (median), and 25 th percentiles, with lines extending from the top/bottom of the boxplot indicating the largest/smallest observation within ±1.5∗IQR (inter-quartile range). P-value significance (∗∗∗∗: p < 0.0001, ∗∗∗: p < 0.001, ∗∗: p < 0.01, and ∗: p < 0.05).
Article Snippet: Soluble CD14 (sCD14) levels were quantified using the
Techniques: Clinical Proteomics, Marker, Plasmid Preparation, Concentration Assay
Journal: Experimental & Molecular Medicine
Article Title: TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
doi: 10.1038/s12276-024-01225-y
Figure Lengend Snippet: a , b Serum concentrations of soluble CD14, calprotectin, and zonulin in healthy individuals and patients with psoriasis. c Schematic of imiquimod (IMQ)-induced psoriatic inflammation. d Serum fluorescein isothiocyanate (FITC)-dextran fluorescence and soluble CD14 and calprotectin concentrations in mice. e Images of hematoxylin and eosin-stained tissues from the small intestine (SI) and large intestine (LI). Scale bars, 124.5 μm. f Ratio of villus length to crypt length. Three to five villi and crypts were analyzed per section. g Calprotectin concentrations in stool. h Sequencing of the stool microbiota of the SI and LI of mice treated with IMQ ( n = 3) or vehicle cream ( n = 4). Image of the cytokine array membrane ( i ) and the quantified density ( j ). The data are presented as the means ± SDs. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 according to unpaired t tests ( b , d , f , h , and CCL2 and CXCL9 in j ), Mann–Whitney tests (calprotectin in b and j ), or one-way ANOVA with Bonferroni’s multiple comparisons ( g ).
Article Snippet: A
Techniques: Fluorescence, Staining, Sequencing, Cream, Membrane, MANN-WHITNEY