Journal: Drug metabolism and disposition: the biological fate of chemicals

Article Title: Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi-Physiologically Based Modeling Approaches.

doi: 10.1124/dmd.121.000493

Figure Lengend Snippet: Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in MATLAB SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.

Article Snippet: The model construction, parameter estimation, simulations, and sensitivity analyses were conducted with SimBiology version 5.7 hosted in MATLAB R2017b with Optimization Toolbox version 8.0 (The Mathworks Inc., Natick, MA).

Techniques:

Journal: Drug metabolism and disposition: the biological fate of chemicals

Article Title: Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi-Physiologically Based Modeling Approaches.

doi: 10.1124/dmd.121.000493

Figure Lengend Snippet: Fig. 6. Observed plasma concentration vs. time profiles of maribavir in cynomolgus monkey overlaid with fitted curves [BDC only (A)] or simulations [intact animals (B, C, D, and E)] in MATLAB SimBiology. (A) Observed data in individual BDC animals overlaid with fitted curve; (B) simulated data with a single intravenous administration in intact animals, using fm(Gluc) at 0.728 or 0.853 at both 5-mg/kg and 13-mg/kg doses, overlaid with individually observed data; (C) simulated data with a single p.o. administration in intact animals, using fm(Gluc) at 0.728 at 10-mg/kg dose, overlaid with individually observed data; (D) simulated data with repeated b.i.d. p.o. administration at 10, 30, or 100 mg/kg in intact male animals within the first 8 hours on day 2, using fm(Gluc) at 0.728, overlaid with individually observed data (Koszalka et al., 2002); (E) simulated data with repeated b.i.d. p.o. administrations at 10, 30, or 100 mg/kg in intact male animals within the first 8 hours on day 27, using fm(Gluc) at 0.728, overlaid with individually observed data (Koszalka et al., 2002).

Article Snippet: The model construction, parameter estimation, simulations, and sensitivity analyses were conducted with SimBiology version 5.7 hosted in MATLAB R2017b with Optimization Toolbox version 8.0 (The Mathworks Inc., Natick, MA).

Techniques: Clinical Proteomics, Concentration Assay

Journal: PLOS Computational Biology

Article Title: Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models

doi: 10.1371/journal.pcbi.1010098

Figure Lengend Snippet: Hardware and software specification for model reproducibility.

Article Snippet: Simulation , MATLAB R2019b; MATLAB GPU coder , Simulation , MATLAB R2020a; CUDA 8.0; Visual Studio 2015.

Techniques: Software

Journal: The EMBO Journal

Article Title: Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease

doi: 10.15252/embj.2022112453

Figure Lengend Snippet: Antibodies, chemicals, kits, recombinant proteins, peptides, and software used in the study.

Article Snippet: Statistical analysis was performed in Prism 8.0 (GraphPad) with the exception of SPECT data analysis where the Matlab (R2017b), and whole‐cell patch‐clamp recording where IBM SPSS Statistic (Version 21) are used.

Techniques: Recombinant, Software, In Situ, Blocking Assay, SYBR Green Assay, Reporter Assay, Isolation, shRNA