math1-cre Search Results


math1cre  (Jackson Laboratory)
86
Jackson Laboratory math1cre
( A-B ) MuAstV genomes quantified in fecal pellets and duodenal tissue of WT (n=10) and Ifnlr1 −/− mice (n=6-10) at 5 dpi. ( C ) Duodenal sections from WT and Ifnlr1 −/− mice were hybridized with probes for muAstV (green), Ifnl2 (red) and Muc2 (gray). Cell nuclei were stained using DAPI (blue). Representative images are shown. ( D ) Quantification of goblet cells and muAstV-infected cells in duodenal sections of WT and Ifnlr1 −/− mice (n=3). ( E ) Quantification of muAstV-infected goblet cells (muAstV+ Muc2+) or enterocytes (muAstV+ Muc2−) in duodenum of WT and Ifnlr1 −/− mice. ( F-K ) muAstV genomes quantified in fecal pellets and intestinal tissues of (F,G) Ifnlr1 f/f (n=8) and littermate Ifnlr1 f/f - Vilcre (n=8) mice, (H,I) Ifnlr1 f/f (n=7) and littermate Ifnlr1 f/f - <t>Math1cre</t> (n=10) mice, or (J,K) Ifnlr1 f/f (n=8) and littermate Ifnlr1 f/f - Alpicre (n=8) mice at 5 dpi. Results were analyzed using Mann-Whitney test (A, B and F-K) . ***P<0.0001, **P<0.001. *P<0.01. Scale bar=25μm. Bars indicate mean of all data points.
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Image Search Results


( A-B ) MuAstV genomes quantified in fecal pellets and duodenal tissue of WT (n=10) and Ifnlr1 −/− mice (n=6-10) at 5 dpi. ( C ) Duodenal sections from WT and Ifnlr1 −/− mice were hybridized with probes for muAstV (green), Ifnl2 (red) and Muc2 (gray). Cell nuclei were stained using DAPI (blue). Representative images are shown. ( D ) Quantification of goblet cells and muAstV-infected cells in duodenal sections of WT and Ifnlr1 −/− mice (n=3). ( E ) Quantification of muAstV-infected goblet cells (muAstV+ Muc2+) or enterocytes (muAstV+ Muc2−) in duodenum of WT and Ifnlr1 −/− mice. ( F-K ) muAstV genomes quantified in fecal pellets and intestinal tissues of (F,G) Ifnlr1 f/f (n=8) and littermate Ifnlr1 f/f - Vilcre (n=8) mice, (H,I) Ifnlr1 f/f (n=7) and littermate Ifnlr1 f/f - Math1cre (n=10) mice, or (J,K) Ifnlr1 f/f (n=8) and littermate Ifnlr1 f/f - Alpicre (n=8) mice at 5 dpi. Results were analyzed using Mann-Whitney test (A, B and F-K) . ***P<0.0001, **P<0.001. *P<0.01. Scale bar=25μm. Bars indicate mean of all data points.

Journal: Mucosal immunology

Article Title: MDA5-MAVS and interferon-lambda signaling in the intestinal epithelium limit murine astrovirus infection

doi: 10.1016/j.mucimm.2025.12.002

Figure Lengend Snippet: ( A-B ) MuAstV genomes quantified in fecal pellets and duodenal tissue of WT (n=10) and Ifnlr1 −/− mice (n=6-10) at 5 dpi. ( C ) Duodenal sections from WT and Ifnlr1 −/− mice were hybridized with probes for muAstV (green), Ifnl2 (red) and Muc2 (gray). Cell nuclei were stained using DAPI (blue). Representative images are shown. ( D ) Quantification of goblet cells and muAstV-infected cells in duodenal sections of WT and Ifnlr1 −/− mice (n=3). ( E ) Quantification of muAstV-infected goblet cells (muAstV+ Muc2+) or enterocytes (muAstV+ Muc2−) in duodenum of WT and Ifnlr1 −/− mice. ( F-K ) muAstV genomes quantified in fecal pellets and intestinal tissues of (F,G) Ifnlr1 f/f (n=8) and littermate Ifnlr1 f/f - Vilcre (n=8) mice, (H,I) Ifnlr1 f/f (n=7) and littermate Ifnlr1 f/f - Math1cre (n=10) mice, or (J,K) Ifnlr1 f/f (n=8) and littermate Ifnlr1 f/f - Alpicre (n=8) mice at 5 dpi. Results were analyzed using Mann-Whitney test (A, B and F-K) . ***P<0.0001, **P<0.001. *P<0.01. Scale bar=25μm. Bars indicate mean of all data points.

Article Snippet: Ifnlr1 f/f ( Ifnlr1 tm1a(EUCOMM)Wtsi ) 17 and Mavs f/f 24 mice were crossed to Villincre (IECs) 18 , Dckl1cre mice (tuft cells) 25 , Math1cre (secretory intestinal epithelial cells; catalogue no. 011104 from Jackson Laboratories) and Alpicre ERT2 (enterocytes) 20 lines for selective constitutive disruption of Ifnlr1 and Mavs in the indicated cell types.

Techniques: Staining, Infection, MANN-WHITNEY

( A-D ) muAstV genomes quantified in fecal pellets and duodenal tissue of (A,B) Mavs f/f (n=6-8) and littermate Mavs f/f -Vavcre (n=8-12) mice or (C,D) Mavs f/f (n=8-9) and littermate Mavs f/f -Vilcre (n=6-8) mice at 5 dpi. ( E ) Duodenal sections from Mavs f/f and Mavs f/f -Vilcre mice were hybridized with probes for muAstV (green) and Muc2 (red). Cell nuclei were stained using DAPI (blue). Representative images are shown. ( F-K ) muAstV genomes quantified in fecal pellets and duodenal tissue of ( F,G ) Mavs f/f (n=7) and littermate Mavs f/f -Math1cre (n=10) mice, (H,I) Mavs f/f (n=7) and littermate Mavs f/f -Alpicre (n=7) mice, (J,K) Mavs f/f (n=10) and littermate Mavs f/f -Dclk1cre (n=6) at 5 dpi. Results were analyzed using Mann-Whitney test (A-D and F-K) . ***P<0.0001, **P<0.001. *P<0.01. ns=not significant. Scale bar=25μm. Bars indicate mean of all data points.

Journal: Mucosal immunology

Article Title: MDA5-MAVS and interferon-lambda signaling in the intestinal epithelium limit murine astrovirus infection

doi: 10.1016/j.mucimm.2025.12.002

Figure Lengend Snippet: ( A-D ) muAstV genomes quantified in fecal pellets and duodenal tissue of (A,B) Mavs f/f (n=6-8) and littermate Mavs f/f -Vavcre (n=8-12) mice or (C,D) Mavs f/f (n=8-9) and littermate Mavs f/f -Vilcre (n=6-8) mice at 5 dpi. ( E ) Duodenal sections from Mavs f/f and Mavs f/f -Vilcre mice were hybridized with probes for muAstV (green) and Muc2 (red). Cell nuclei were stained using DAPI (blue). Representative images are shown. ( F-K ) muAstV genomes quantified in fecal pellets and duodenal tissue of ( F,G ) Mavs f/f (n=7) and littermate Mavs f/f -Math1cre (n=10) mice, (H,I) Mavs f/f (n=7) and littermate Mavs f/f -Alpicre (n=7) mice, (J,K) Mavs f/f (n=10) and littermate Mavs f/f -Dclk1cre (n=6) at 5 dpi. Results were analyzed using Mann-Whitney test (A-D and F-K) . ***P<0.0001, **P<0.001. *P<0.01. ns=not significant. Scale bar=25μm. Bars indicate mean of all data points.

Article Snippet: Ifnlr1 f/f ( Ifnlr1 tm1a(EUCOMM)Wtsi ) 17 and Mavs f/f 24 mice were crossed to Villincre (IECs) 18 , Dckl1cre mice (tuft cells) 25 , Math1cre (secretory intestinal epithelial cells; catalogue no. 011104 from Jackson Laboratories) and Alpicre ERT2 (enterocytes) 20 lines for selective constitutive disruption of Ifnlr1 and Mavs in the indicated cell types.

Techniques: Control, Infection, Staining, MANN-WHITNEY