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Image Search Results
Journal: Brain Communications
Article Title: Brain-injury and Alzheimer’s disease biomarkers are elevated in patients with suspected infection and physiological derangement: importance for context-specific interpretation of Alzheimer’s biomarkers
doi: 10.1093/braincomms/fcag063
Figure Lengend Snippet: Boxplots of the p-tau-217 levels in patients with suspected sepsis (n = 24) taken on recruitment, age- and sex- matched non-infected controls (n = 20) and Alzheimer’s disease patients (n = 9). Boxplots showing the univariate distribution of plasma p-tau-217 (pg/mL) levels in participants with suspected sepsis (n = 24), age- and sex-matched non-infected controls (n = 20), and patients with Alzheimer’s disease (n = 9). Each box represents the IQR with the median shown as a horizontal line. Individual participant data points, each representing a single participant’s biomarker measurement, are overlaid as black dots. The red dashed line indicates the reported binary threshold for Aβ-positive positron emission tomography scan in Alzheimer’s disease (0.42 pg/ml). A Kruskal–Wallis test showed significant differences across groups (χ 2 = 20.886, df = 2, P < 0.001). Post-hoc pairwise comparisons using Dunn’s test with Benjamini–Hochberg adjustment showed: Alzheimer’s disease versus non-infected controls, Z = 3.957, P < 0.001; suspected sepsis versus non-infected controls, Z = −3.713, P < 0.001; Alzheimer’s disease versus suspected sepsis, Z = 1.187, P = 0.118.
Article Snippet: In the suspected sepsis samples, non-infected age- and sex-matched controls and additional ‘positive’ controls taken from Alzheimer’s patients (n = 9),
Techniques: Infection, Clinical Proteomics, Biomarker Discovery, Positron Emission Tomography
Journal: Brain Communications
Article Title: Brain-injury and Alzheimer’s disease biomarkers are elevated in patients with suspected infection and physiological derangement: importance for context-specific interpretation of Alzheimer’s biomarkers
doi: 10.1093/braincomms/fcag063
Figure Lengend Snippet: Stacked bar graphs of the numbers of patients in each group with p-tau-217 levels in different reference ranges, demonstrating that nearly half of the patients with suspected sepsis had elevated plasma p-tau-217. Distribution of plasma p-tau-217 concentrations (pg/ml) categorized as low (<0.4 pg/ml), intermediate (0.4–0.63 pg/ml) and high (>0.63 pg/ml) across participant groups: non-infected controls (n = 20), patients with suspected sepsis (n = 24) and Alzheimer’s disease controls (n = 9). The stacked bars show the proportion of participants in each category, with percentages annotated within each segment.
Article Snippet: In the suspected sepsis samples, non-infected age- and sex-matched controls and additional ‘positive’ controls taken from Alzheimer’s patients (n = 9),
Techniques: Clinical Proteomics, Infection