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Image Search Results
Journal: Pharmaceutical Research
Article Title: Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
doi: 10.1007/s11095-019-2582-y
Figure Lengend Snippet: Toxicity Parameters Utilized in the Simulation of the Five Macrolide Compounds in DILIsym v5A
Article Snippet: PBPK models for the five
Techniques: Inhibition
Journal: Pharmaceutical Research
Article Title: Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
doi: 10.1007/s11095-019-2582-y
Figure Lengend Snippet: Most Likely Mechanism of Toxicity Suggested by the Simulation Results for Each Macrolide Antibiotic
Article Snippet: PBPK models for the five
Techniques: Inhibition
Journal: Frontiers in Pharmacology
Article Title: Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production
doi: 10.3389/fphar.2017.00202
Figure Lengend Snippet: (Left) Dose-dependent effects of macrolide antibiotics on the release of NO from LPS-stimulated murine macrophages. The cells were incubated for 24 h with various concentrations of ERY (A) , RXT (B) , CLT (C) , and AZT (D) . Max doses (250 μM for ERY, RXT and AZT and 62.5 μM for CLT) were adjusted to achieve a cell viability ≥ 80%. Values on the vertical axe represent the percentage of control of NO formation in the culture medium after addition of LPS. (Right) Human in vitro liver microsome stabilities ( n = 3 per time point) for ERY (E) , RXT (F) , CLT (G) , and AZT (H) . Data are means ± STDEV; n = 6 for each concentration and time point.
Article Snippet: The characteristics of the clinical nonantimicrobial properties of
Techniques: Incubation, Control, In Vitro, Concentration Assay