macrolides Search Results


90
European Directorate for the Quality of Medicines and HealthCare azithromycin
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TIB MOLBIOL modular mycoplasma macrolide
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ANPEL Laboratory deuterium-labeled internal standards for macrolides
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Federation of European Neuroscience Societies macrolide
Macrolide, supplied by Federation of European Neuroscience Societies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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DILIsym Services Inc pbpk models for the five macrolide antibiotics
Toxicity Parameters Utilized in the Simulation of the Five <t> Macrolide </t> Compounds in DILIsym v5A
Pbpk Models For The Five Macrolide Antibiotics, supplied by DILIsym Services Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Stamm GmbH oral macrolide antibiotics
Toxicity Parameters Utilized in the Simulation of the Five <t> Macrolide </t> Compounds in DILIsym v5A
Oral Macrolide Antibiotics, supplied by Stamm GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Macrolide Pharmaceuticals bugworks research
Toxicity Parameters Utilized in the Simulation of the Five <t> Macrolide </t> Compounds in DILIsym v5A
Bugworks Research, supplied by Macrolide Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Becton Dickinson clarithromycin (macrolide)
Toxicity Parameters Utilized in the Simulation of the Five <t> Macrolide </t> Compounds in DILIsym v5A
Clarithromycin (Macrolide), supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Furuuchi Chemical Corp sixteen-membered macrolides
Toxicity Parameters Utilized in the Simulation of the Five <t> Macrolide </t> Compounds in DILIsym v5A
Sixteen Membered Macrolides, supplied by Furuuchi Chemical Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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HEMEX Laboratories macrolide for malaria
Toxicity Parameters Utilized in the Simulation of the Five <t> Macrolide </t> Compounds in DILIsym v5A
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Nagai Nori USA INC macrolide therapy
(Left) Dose-dependent effects of <t>macrolide</t> antibiotics on the release of NO from LPS-stimulated murine macrophages. The cells were incubated for 24 h with various concentrations of ERY (A) , RXT (B) , CLT (C) , and AZT (D) . Max doses (250 μM for ERY, RXT and AZT and 62.5 μM for CLT) were adjusted to achieve a cell viability ≥ 80%. Values on the vertical axe represent the percentage of control of NO formation in the culture medium after addition of LPS. (Right) Human in vitro liver microsome stabilities ( n = 3 per time point) for ERY (E) , RXT (F) , CLT (G) , and AZT (H) . Data are means ± STDEV; n = 6 for each concentration and time point.
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Macrolide Pharmaceuticals antibiotic development
(Left) Dose-dependent effects of <t>macrolide</t> antibiotics on the release of NO from LPS-stimulated murine macrophages. The cells were incubated for 24 h with various concentrations of ERY (A) , RXT (B) , CLT (C) , and AZT (D) . Max doses (250 μM for ERY, RXT and AZT and 62.5 μM for CLT) were adjusted to achieve a cell viability ≥ 80%. Values on the vertical axe represent the percentage of control of NO formation in the culture medium after addition of LPS. (Right) Human in vitro liver microsome stabilities ( n = 3 per time point) for ERY (E) , RXT (F) , CLT (G) , and AZT (H) . Data are means ± STDEV; n = 6 for each concentration and time point.
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Image Search Results


Toxicity Parameters Utilized in the Simulation of the Five  Macrolide  Compounds in DILIsym v5A

Journal: Pharmaceutical Research

Article Title: Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

doi: 10.1007/s11095-019-2582-y

Figure Lengend Snippet: Toxicity Parameters Utilized in the Simulation of the Five Macrolide Compounds in DILIsym v5A

Article Snippet: PBPK models for the five macrolide antibiotics were constructed within DILIsym to describe disposition of macrolides in humans.

Techniques: Inhibition

Most Likely Mechanism of Toxicity Suggested by the Simulation Results for Each  Macrolide  Antibiotic

Journal: Pharmaceutical Research

Article Title: Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

doi: 10.1007/s11095-019-2582-y

Figure Lengend Snippet: Most Likely Mechanism of Toxicity Suggested by the Simulation Results for Each Macrolide Antibiotic

Article Snippet: PBPK models for the five macrolide antibiotics were constructed within DILIsym to describe disposition of macrolides in humans.

Techniques: Inhibition

(Left) Dose-dependent effects of macrolide antibiotics on the release of NO from LPS-stimulated murine macrophages. The cells were incubated for 24 h with various concentrations of ERY (A) , RXT (B) , CLT (C) , and AZT (D) . Max doses (250 μM for ERY, RXT and AZT and 62.5 μM for CLT) were adjusted to achieve a cell viability ≥ 80%. Values on the vertical axe represent the percentage of control of NO formation in the culture medium after addition of LPS. (Right) Human in vitro liver microsome stabilities ( n = 3 per time point) for ERY (E) , RXT (F) , CLT (G) , and AZT (H) . Data are means ± STDEV; n = 6 for each concentration and time point.

Journal: Frontiers in Pharmacology

Article Title: Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production

doi: 10.3389/fphar.2017.00202

Figure Lengend Snippet: (Left) Dose-dependent effects of macrolide antibiotics on the release of NO from LPS-stimulated murine macrophages. The cells were incubated for 24 h with various concentrations of ERY (A) , RXT (B) , CLT (C) , and AZT (D) . Max doses (250 μM for ERY, RXT and AZT and 62.5 μM for CLT) were adjusted to achieve a cell viability ≥ 80%. Values on the vertical axe represent the percentage of control of NO formation in the culture medium after addition of LPS. (Right) Human in vitro liver microsome stabilities ( n = 3 per time point) for ERY (E) , RXT (F) , CLT (G) , and AZT (H) . Data are means ± STDEV; n = 6 for each concentration and time point.

Article Snippet: The characteristics of the clinical nonantimicrobial properties of macrolide therapy include effective doses that are much lower than the minimal inhibitory concentration (i.e., low-dose macrolide therapy) (Nagai et al., ; Fujii et al., ; Kudoh et al., ; Shitrit et al., ).

Techniques: Incubation, Control, In Vitro, Concentration Assay