Journal: Psychiatric genetics

Article Title: Long non-coding RNAs in psychiatric disorders

doi: 10.1097/YPG.0000000000000129

Figure Lengend Snippet: [Sense, LncRNAs are transcribed from the same genomic strand as the protein-coding mRNAs; Intergenic, located between two protein-coding genes and at least 1 kb away from these genes; Antisense, transcribed from the antisense strand; Intronic, located within the intron of protein coding genes; Bidirectional, oriented head to head with a protein-coding gene within 1kb. Arrow direction: 5′ → 3′]

Article Snippet: These lncRNAs ( www.arraystar.com ) include: (1) LincRNAs (1 st set).

Techniques:

Journal: Cancer Gene Therapy

Article Title: KRAS-related long noncoding RNAs in human cancers

doi: 10.1038/s41417-021-00381-x

Figure Lengend Snippet: As key gene regulators, tumor suppressor miRNAs bind to their targets and interfere with translation. The RNA‐induced silencing complex (RISK) guides the antisense strand of the miRNA to bind to its target KRAS mRNA sequence in a complementary manner, forming a double‐stranded helix. Perfect complementarity results in endonucleolytic cleavage, while partial complementarity subjects mRNA to translational repression. Oncogenic lncRNAs act as ceRNA decoys by presenting complementary sequences with MREs to sponge miRNAs from their target KRAS mRNAs. lncRNAs consequently promote KRAS mRNA stabilization and thus its upregulation.

Article Snippet: Therefore, peptides/proteins encoded by lncRNAs might be hidden oncopeptides/oncoproteins representing promising drug targets for treating tumor growth [ ].

Techniques: Sequencing

Journal: Cancer Gene Therapy

Article Title: KRAS-related long noncoding RNAs in human cancers

doi: 10.1038/s41417-021-00381-x

Figure Lengend Snippet: lncRNAs are presented in green, indicating their upregulation as oncogenic regulators in carcinogenesis. miRNAs with tumor suppressor activity are presented in red, indicating their repression due to the sponging effect of lncRNAs in malignancies. The left and right panels illustrate the confirmed and potential KRAS-related lncRNAs as well as their miRNAs, respectively (Supplementary Table ).

Article Snippet: Therefore, peptides/proteins encoded by lncRNAs might be hidden oncopeptides/oncoproteins representing promising drug targets for treating tumor growth [ ].

Techniques: Activity Assay

Journal: Data in Brief

Article Title: Saturated fatty acid regulated lncRNA dataset during in vitro human embryonic neurogenesis

doi: 10.1016/j.dib.2018.10.101

Figure Lengend Snippet: Expression profile of lncRNAs from different stages of in vitro embryonic neuorgenesis. The expression of 372 functionally known lncRNAs was analyzed by RT-qPCR using ‘nrStar™ Human Functional LncRNA PCR Array’ on H9 cells at days 0, 12, 44 and 70 of neural differentiation. The delta CT values for individual lncRNAs are shown after normalization to 18S rRNA. The bright red color indicates highest expression whereas bright blue shows lowest expression.

Article Snippet: The expression analysis of lncRNAs was performed by RT-qPCR on vehicle control and palmitate treated cells from 4 stages of differentiation, D0 (undifferentiated hESCs), D12 (neural stem cells), D44 (neural progenitors) and D70 (neurons) using lncRNAs array plates from Arraystar Inc. which contains 372 functionally identified lncRNAs found to be associated with lipid metabolism and other pathways (Cat# AS-NR-004). shows data on expression profile of these lncRNAs whereas contains list of these lncRNAs differentially expressed in the presence of palmitate (250 μM) relative to vehicle control at D0, D12, D44 and D70 of neural differentiation.

Techniques: Expressing, In Vitro, Quantitative RT-PCR, Functional Assay

Journal: Data in Brief

Article Title: Saturated fatty acid regulated lncRNA dataset during in vitro human embryonic neurogenesis

doi: 10.1016/j.dib.2018.10.101

Figure Lengend Snippet: Expression profile of lncRNAs from different stages of in vitro embryonic neuorgenesis. The expression of 372 functionally known lncRNAs was analyzed by RT-qPCR using ‘nrStar™ Human Functional LncRNA PCR Array’ on H9 cells at days 0, 12, 44 and 70 of neural differentiation. The delta CT values for individual lncRNAs are shown after normalization to 18S rRNA. The bright red color indicates highest expression whereas bright blue shows lowest expression.

Article Snippet: The expression analysis of lncRNAs was performed on palmitate treated and vehicle control cells from four stages of neural differentiation of hESCs, D0, D12, D44 and D70 using Long non-coding RNAs (lncRNAs) array plates were purchased from Arraystar, Inc. - USA (Cat# AS-NR-004) as described .

Techniques: Expressing, In Vitro, Quantitative RT-PCR, Functional Assay