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Image Search Results
Journal: Journal of the American Society for Mass Spectrometry
Article Title: Tracking the Behavior of Monoclonal Antibody Product Quality Attributes Using a Multi-Attribute Method Workflow.
doi: 10.1021/jasms.0c00432
Figure Lengend Snippet: Figure 5. NPD workflow for HCP and sequence variant analysis. (a) HCP analysis was carried out by spiking cathepsin L and rhLPL at different concentrations into a commercially available IgG1. (b) Sequence variant analysis was carried out using the same commercially available IgG1 originator and an in-house produced biosimilar. For both analyses, the samples were digested with trypsin, and analysis was carried out as previously described.
Article Snippet: Recombinant mouse cathepsin L protein and
Techniques: Sequencing, Variant Assay, Produced