le 135 Search Results


le135  (Tocris)
92
Tocris le135
Figure 4. ATRA and other RAR agonists induce TRAIL-R1 expression (A), which can be abolished by RAR antagonists (B and C) or by the knockdown of RARs (D). A, H157 cells were treated with 1-mmol/L ATRA or other indicated retinoids for 16 hours. B and C, H157 cells were pretreated with the indicated concentrations of <t>LE135</t> or Ro415253 for 30 minutes and then cotreated with 1 mmol/L ATRA for 16 hours. D, H157 cells were transfected with control (Ctrl), RARa/g, RARb, or RARa/g plus RARb siRNAs for 72 hours. The cells were then treated with DMSO or 1 mmol/L ATRA for an additional 16 hours. After the aforementioned treatments, the whole cell protein lysates were prepared from these cells and used for the detection of indicated proteins with Western blot analysis.
Le135, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/le+135/10__1158_slash_0008___5472__can___10___4180-47-3-7?v=Tocris
Average 92 stars, based on 1 article reviews
le135 - by Bioz Stars, 2026-07
92/100 stars
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le135  (Santa Cruz Biotechnology)
90
Santa Cruz Biotechnology le135
Figure 4. ATRA and other RAR agonists induce TRAIL-R1 expression (A), which can be abolished by RAR antagonists (B and C) or by the knockdown of RARs (D). A, H157 cells were treated with 1-mmol/L ATRA or other indicated retinoids for 16 hours. B and C, H157 cells were pretreated with the indicated concentrations of <t>LE135</t> or Ro415253 for 30 minutes and then cotreated with 1 mmol/L ATRA for 16 hours. D, H157 cells were transfected with control (Ctrl), RARa/g, RARb, or RARa/g plus RARb siRNAs for 72 hours. The cells were then treated with DMSO or 1 mmol/L ATRA for an additional 16 hours. After the aforementioned treatments, the whole cell protein lysates were prepared from these cells and used for the detection of indicated proteins with Western blot analysis.
Le135, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/le+135/pmc03954489-141-6-9?v=Santa+Cruz+Biotechnology
Average 90 stars, based on 1 article reviews
le135 - by Bioz Stars, 2026-07
90/100 stars
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le 135  (Axon Medchem LLC)
90
Axon Medchem LLC le 135
Figure 4. ATRA and other RAR agonists induce TRAIL-R1 expression (A), which can be abolished by RAR antagonists (B and C) or by the knockdown of RARs (D). A, H157 cells were treated with 1-mmol/L ATRA or other indicated retinoids for 16 hours. B and C, H157 cells were pretreated with the indicated concentrations of <t>LE135</t> or Ro415253 for 30 minutes and then cotreated with 1 mmol/L ATRA for 16 hours. D, H157 cells were transfected with control (Ctrl), RARa/g, RARb, or RARa/g plus RARb siRNAs for 72 hours. The cells were then treated with DMSO or 1 mmol/L ATRA for an additional 16 hours. After the aforementioned treatments, the whole cell protein lysates were prepared from these cells and used for the detection of indicated proteins with Western blot analysis.
Le 135, supplied by Axon Medchem LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/le+135/pmc02911635-399-8-10?v=Axon+Medchem+LLC
Average 90 stars, based on 1 article reviews
le 135 - by Bioz Stars, 2026-07
90/100 stars
  Buy from Supplier
le 135  (Cayman Chemical)
N/A
LE 135 1 mg
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le 135  (Toronto Research Chemicals)
N/A
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le 135  (Biosynth Carbosynth)
N/A
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le 135  (Aladdin Scientific Corporation)
N/A
Application：LE 135 has been used for in vitro islet treatment.
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le 135  (BOC Sciences)
N/A
LE 135 is a retinoic acid antagonist which shows moderate selectivity for RARβ over RARα. It can inhibit human HL-60 leukemia cell differentiation induced by Am80 with IC50 value of 150 nM.
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Image Search Results


Figure 4. ATRA and other RAR agonists induce TRAIL-R1 expression (A), which can be abolished by RAR antagonists (B and C) or by the knockdown of RARs (D). A, H157 cells were treated with 1-mmol/L ATRA or other indicated retinoids for 16 hours. B and C, H157 cells were pretreated with the indicated concentrations of LE135 or Ro415253 for 30 minutes and then cotreated with 1 mmol/L ATRA for 16 hours. D, H157 cells were transfected with control (Ctrl), RARa/g, RARb, or RARa/g plus RARb siRNAs for 72 hours. The cells were then treated with DMSO or 1 mmol/L ATRA for an additional 16 hours. After the aforementioned treatments, the whole cell protein lysates were prepared from these cells and used for the detection of indicated proteins with Western blot analysis.

Journal: Cancer Research

Article Title: Retinoic Acid Enhances TRAIL-Induced Apoptosis in Cancer Cells by Upregulating TRAIL Receptor 1 Expression

doi: 10.1158/0008-5472.can-10-4180

Figure Lengend Snippet: Figure 4. ATRA and other RAR agonists induce TRAIL-R1 expression (A), which can be abolished by RAR antagonists (B and C) or by the knockdown of RARs (D). A, H157 cells were treated with 1-mmol/L ATRA or other indicated retinoids for 16 hours. B and C, H157 cells were pretreated with the indicated concentrations of LE135 or Ro415253 for 30 minutes and then cotreated with 1 mmol/L ATRA for 16 hours. D, H157 cells were transfected with control (Ctrl), RARa/g, RARb, or RARa/g plus RARb siRNAs for 72 hours. The cells were then treated with DMSO or 1 mmol/L ATRA for an additional 16 hours. After the aforementioned treatments, the whole cell protein lysates were prepared from these cells and used for the detection of indicated proteins with Western blot analysis.

Article Snippet: CH55, CD271, and LE135 were purchased from Tocris Bioscience.

Techniques: Expressing, Knockdown, Transfection, Control, Western Blot