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Image Search Results
Journal: Drug Design, Development and Therapy
Article Title: Baolier Capsule’s Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis
doi: 10.2147/DDDT.S499598
Figure Lengend Snippet: Key Resources Table
Article Snippet:
Techniques: Control, shRNA, Sequencing, Staining, Fluorescence, Microscopy, AST Assay, Phospholipid Assay, Mass Spectrometry
Journal: NPJ biofilms and microbiomes
Article Title: Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling.
doi: 10.1038/s41522-023-00415-2
Figure Lengend Snippet: Fig. 1 L. reuteri supplementation ameliorates dyslipidemia in constant darkness rats. a Timeline depicting the treatments of darkness and L. reuteri in different groups of the L. reuteri-treated rat model. b Representative estrous cycles. M, metestrus; D, diestrus; P, proestrus; E, estrus. c Quantitative analysis of estrous cycles. d Representative hematoxylin and eosin staining of ovaries. Asterisk stands for corpus luteum. Scale bar: 200 μm. e–g Serum concentrations of LH/FSH ratio (e), testosterone (f), and SHBG (g) detected by ELISA. h Body weight changes. i Representative Oil Red O staining of livers. Scale bar: 50 μm and 25 μm. j Representative images of liver ultrastructure detected by transmission electron microscope. Scale bar: 40 μm and 1 μm. k Hepatic contents of TG, CHOL, HDL-C, LDL-C, and NEFA detected by ELISA. l Serum concentrations of TG, CHOL, HDL-C, LDL-C, and NEFA detected by ELISA. Statistical analysis was performed with one-way ANOVA followed by Newman–Keuls multiple comparison test. n = 8 per group. Data present means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.
Article Snippet: The concentrations of TG, total CHOL, HDL-C, LDL-C, and NEFA in rat sera and liver tissues were detected using Triglyceride Quantification Assay Kit (#ab65336, Abcam), HDL and LDL/VLDL Cholesterol Assay Kit (#ab65390, Abcam),
Techniques: Staining, Enzyme-linked Immunosorbent Assay, Transmission Assay, Microscopy, Comparison
Journal: NPJ biofilms and microbiomes
Article Title: Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling.
doi: 10.1038/s41522-023-00415-2
Figure Lengend Snippet: Fig. 2 Liver transcriptome analysis of L. reuteri-treated darkness rats. Heatmaps displaying 36 highly expressed genes (a) and 76 lowly expressed genes (b) in the liver of darkness rats compared with control and DL.reuteri rats through DEG analysis using Ballgown software (| fold change | > 0.6 in the log2 ratio value, raw P < 0.05). c Top terms from GO analysis (above) and terms from KEGG analysis (below) of the 112 differential genes in the DEG analysis. The P values of GO and KEGG analyses were determined on the DAVID website. d Visualization of the top GO and KEGG terms related with lipid metabolism and circadian rhythm in the DEG analysis. e Spearman rank correlations between module eigengenes (ME) and clinical biochemical index in the WGCNA analysis (|ρ | > 0.3, *P < 0.05). f Visualization of the top GO and KEGG terms related with lipid metabolism and circadian rhythm of purple module genes (102) in the WGCNA analysis. Circle, genes; Square, KEGG terms; Hexagon, GO terms. The bigger the square or hexagon, the more genes involved. g Crosstalk among different groups of genes identified the possible target genes taking essential roles in the lipid metabolism of L. reuteri-treated darkness rats. h mRNA abundances of Galr1, Galr2, Nr1d1, Nr1d2, Insig2, Srebf1, Lxra, and Rxra in rat liver detected by qPCR. β-Actin was used as a loading control for qPCR analyses. i Serum galanin concentration detected by ELISA. Statistical analysis (h, i) was performed with one-way ANOVA followed by Newman–Keuls multiple comparison test. n = 8 per group. Data present means ± SEM. *P < 0.05, **P < 0.01.
Article Snippet: The concentrations of TG, total CHOL, HDL-C, LDL-C, and NEFA in rat sera and liver tissues were detected using Triglyceride Quantification Assay Kit (#ab65336, Abcam), HDL and LDL/VLDL Cholesterol Assay Kit (#ab65390, Abcam),
Techniques: Control, Software, Concentration Assay, Enzyme-linked Immunosorbent Assay, Comparison